The failure of antibiotics to prevent heart attacks

British Medical Journal

Volumn 331, Issue 7513, 2005, Pages 361-362

  Taylor Robinson, David ^a   Boman, Jens ^b  

^a ST MARY S HOSPITAL   (United Kingdom)

^b UMEÅ UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; AZITHROMYCIN; CLARITHROMYCIN; GATIFLOXACIN; PLACEBO;

ABDOMINAL AORTA ANEURYSM; ANTIBIOTIC THERAPY; ANTIMICROBIAL ACTIVITY; CHLAMYDOPHILA PNEUMONIAE; CLINICAL TRIAL; CORONARY ARTERY BYPASS GRAFT; CORONARY ARTERY DISEASE; EDITORIAL; EPIDEMIOLOGICAL DATA; FOLLOW UP; HEART INFARCTION; HUMAN; INFLAMMATION; META ANALYSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SYPHILIS; SYSTEMATIC REVIEW; TREATMENT FAILURE; TREATMENT OUTCOME; TREPONEMA PALLIDUM;

EID: 23844503283     PISSN: 09598146     EISSN: None     Source Type: Journal    
DOI: 10.1136/bmj.331.7513.361     Document Type: Editorial

References (13)

1. Grayston JT, Kronmal RA, Jackson LA, Parisi AF, Muhlestein JB, Cohen JD, et al. ACES Investigators. Azithromycin for the secondary prevention of coronary events. N Eng J Med 2005;352:1637-45.
2. Cannon CP, Braunwald E, McCabe CH, Grayston JT, Muhlestein B, Giugliano RP, et al. Antibiotic treatment of Chlamydia pneumoniae after acute coronary syndrome. N Eng J Med 2005;352:1646-54.
3. Wells BJ, Mainous AG, Dickerson LM. Antibiotics for the secondary prevention of ischemic heart disease. Arch Intern Med 2004;164:2156-61.
4. Taylor-Robinson D, Thomas BJ. Chlamydia pneumoniae in arteries: the facts, their interpretation, and future studies. J Clin Pathol 1998;51:793-7.
5. Gupta S, Leatham EW, Carrington D, Mendall MA, Kaski JC, Camm AJ. Elevated Chlamydia pneumoniae antibodies, cardiovascular events, and azithromycin in male survivors of myocardial infection. Circulation 1997;96:404-7.
6. Gurfinkel E, Bozovich G, Daroca A, Beck E, Mautner B. Randomised trial of roxithromycin in non-Q-wave coronary syndromes: ROXIS pilot study. Lancet 1997;350:404-7.
7. Baxter BT, Pearce WH, Walke EA, Littooy FN, Hallett JW Jr, Kent KC, et al. Prolonged administration of doxycycline in patients with small asymp-tomatic abdominal aortic aneurysms: report of a prospective (Phase II) multicenter study. J Vasc Surg 2002;36:1-12.
8. Sander D, Winbeck K, Klingelhofer J, Etgen T, Conrad D. Progression of early carotid atherosclerosis is only temporarily reduced after treatment of Chlamydia pneumoniae seropositivity. Circulation 2004;109:1010-5.
9. Smieja M, Mahony J, Petrich A, Boman J, Chernesky M. Association of circulating Chlamydia pneumoniae DNA with cardiovascular disease: a systematic review. BMC Infect Dis 2002;2:21.
10. BomanJ, Soderberg S, Forsberg J, Birgander LS, Allard A, Persson K, et al. High prevalence of Chlamydia pneumoniae DNA in peripheral blood mononuclear cells in patients with cardiovascular disease and in middle-aged blood donors. J Infect Dis 1998;178:274-7.
11. Gieffers J, Fullgraf H, Jahn J, Klinger M, Dalhoff K, Katus HA, et al. Chlamydia pneumoniae infection in circulating human monocytes is refactory to antibiotic treatment. Circulation 2001;103:351-6.
12. Berg HF, Maraha B, van der Zee A, Giclis SK, Roholl PJM, Scheffer G-J, et al. Effect of clarithromycin treatment on Chlamydia pneumoniae in vascular tissue of patients with coronary artery disease: a randomised, double-blind, placebo-controlled trial. J Clin Microbiol 2005;43:1325-9.
13. Danesh J. Antibiotics in the prevention of heart attacks. Lancet 2005;365:365-7.