A facile S-transalkylation of 2,2′-bipyridine alkyl sulfides - A new tool for the synthesis of annulated biheterocycles

Tetrahedron Letters

Volumn 46, Issue 37, 2005, Pages 6223-6226

  Branowska, Danuta ^a   Rykowski, Andrzej ^a   Wysocki, Waldemar ^a  

^a SIEDLCE UNIVERSITY OF NATURAL SCIENCES AND HUMANITIES   (Poland)

Author keywords

Annulated diquaternary 2,2 bipyridinium salts; S Transalkylation

Indexed keywords

2,2' BIPYRIDINE DERIVATIVE; HETEROCYCLIC COMPOUND; SULFIDE; THIAZOLE DERIVATIVE;

ALKYLATION; ANALYTIC METHOD; ANNULATION REACTION; ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; REACTION ANALYSIS; RING CLOSING METATHESIS; STRUCTURE ANALYSIS; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

EID: 23844456302     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2005.07.062     Document Type: Article

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17. General procedure for the synthesis of compounds 4a-b, 6a-j and 8a-d. A solution of the 2,2′-bipyridine derivative (1 mmol) in 1,2-dibromoethane or 1,3-dibromopropane (2 ml) was heated at 136-140°C for a number of hours as indicated in Table 1. After cooling, the precipitated solid was filtered off and washed with diethyl ether. The crude products 4a-b were recrystallized from methanol to give light yellow solids. The crude products 6a-j and 8a-d were recrystallized from dichloromethane/methanol mixtures.
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