Canadian Helicobacter Study Group Consesus Conference: Update on the approach to Helicobacter pylori infection in children and adolescents - An evidence-based evaluation

Canadian Journal of Gastroenterology

Volumn 19, Issue 7, 2005, Pages 399-408

  Jones, Nicola L ^a   Sherma, Philip ^a   Fallone, Carlo A ^b   Flook, Nigel ^c   Smaill, Fiona ^c   Veldhuyzen van Zanten, Sander ^d   Hunt, Richard ^c   Thomson, Alan ^e  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^c MCMASTER UNIVERSITY   (Canada)

^d DALHOUSIE UNIVERSITY   (Canada)

^e UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Children; Consensus; Guideline; H pylori; Helicobacter

Indexed keywords

AMOXICILLIN; CLARITHROMYCIN; METRONIDAZOLE; PROTON PUMP INHIBITOR;

ABDOMINAL PAIN; ADOLESCENT; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIGEN DETECTION; BACTERIUM CULTURE; BACTERIUM IDENTIFICATION; CHILD; CONFERENCE PAPER; CONSENSUS DEVELOPMENT; COST EFFECTIVENESS ANALYSIS; DISEASE EXACERBATION; DISEASE SEVERITY; ENDOSCOPIC BIOPSY; EVIDENCE BASED MEDICINE; FAMILY HISTORY; FECES ANALYSIS; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL SYMPTOM; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; IRON DEFICIENCY ANEMIA; MASS SCREENING; METHODOLOGY; MONITORING; NON INVASIVE MEASUREMENT; PATIENT CARE; PRACTICE GUIDELINE; PRIORITY JOURNAL; PUBLISHING; SERODIAGNOSIS; STOMACH CANCER; TREATMENT FAILURE; UREA BREATH TEST;

EID: 23844454901     PISSN: 08357900     EISSN: None     Source Type: Journal    
DOI: 10.1155/2005/390932     Document Type: Conference Paper

References (93)

1. Peek RM Jr, Blaser MJ. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer 2002;2:28-37.
2. Sinha SK, Martin B, Gold BD, et al. The incidence of Helicobacter pylori acquisition in children of a Canadian First Nations community and the potential for parent-to-child transmission. Helicobacter 2004;9:59-68.
3. Sherman P, Hassall E, Hunt RH, et al. Canadian Helicobacter Study Group Consensus Conference on the approach to Helicobacter pylori infection in children and adolescents. Can J Gastroenterol 1999;13:553-9.
4. Gold BD, Colletti RB, Abbott M, et al; North American Society for Pediatric Gastroenterology and Nutrition. Helicobacter pylori infection in children: Recommendations for diagnosis and treatment. J Pediatr Gastroenterol Nutr 2000;31:490-7.
5. Drumm B, Koletzko S, Oderda G. Helicobacter pylori infection in children: A consensus statement. European Pediatric Task Force on Helicobacter pylori. J Pediatr Gastroenterol Nutr 2000;30:207-13.
6. Kato S, Kobayashi A, Sugiyama T, et al. Proposal of guidelines on the management of Helicobacter pylori in children (in Japanese). Jpn J Pediatr Gastroenterol Nutr 1997;11:173-6.
7. Hunt RH, Thomson ABR, Consensus conference participants. Canadian Helicobacter pylori consensus conference. Can J Gastroenterol 1998;12:31-41.
8. Fennerty MB. Is the only good H pylori a dead H pylori? Gastroenterology 1996;111:1773-4.
9. IARC. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans (vol 63). In Lyon: World Health Organization, 1994:177-201.
10. Hunt RH, Fallone C, Veldhuyzen van Zanten S, Sherman P, Smaill F, Thomson AB; Canadian Helicobacter Study Group. Risks and benefits of Helicobacter pylori eradication: Current status. Can J Gastroenterol 2002;16:57-62.
11. Uemura N, Okamoto S, Yamamoto S, et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 2001;345:784-9.
12. Watanabe T, Tada M, Nagai H, et al. Helicobacter pylori infection induces gastric cancer in mongolian gerbils. Gastroenterology 1998;115:642-8.
13. Wong BC, Lam SK, Wong WM, et al. Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: A randomized controlled trial. JAMA 2004;291:187-94.
14. Leung WK, Lin SR, Ching JY, et al. Factors predicting progression of gastric intestinal metaplasia: Results of a randomised trial on Helicobacter pylori eradication. Gut 2004;53:1244-9.
15. Ley C, Mohar A, Guarner J, et al. Helicobacter pylori eradication and gastric preneoplastic conditions: A randomized, double-blind, placebo-controlled trial. Cancer Epidemiol Biomarkers Prev 2004;13:4-10.
16. Bedoya A, Garay J, Sanzon F, et al. Histopathology of gastritis in Helicobacter pylori-infected children from populations at high and low gastric cancer risk. Human Pathol 2003; 34:206-13.
17. Uhlig H, Tannapfel A, Mossner J, et al. Histopathological parameters of Helicobacter pylori-associated gastritis in children and adolescents: Comparison with findings in adults. Scand J Gastroenterol 2003;38:701-6.
18. Guarner J, Bartlett J, Whistler T, et al. Can pre-neoplastic lesions be detected in gastric biopsies of children with Helicobacter pylori infection? J Pediatr Gastroenterol Nutr 2003;37:309-14.
19. Parsonnet J, Harris RA, Hack HM, Owens DK. Modelling cost-effectiveness of Helicobacter pylori screening to prevent gastric cancer: A mandate for clinical trials. Lancet 1996;348:150-4.
20. Gold BD, Kruszon-Moran D, Sobel J, McQuillan GM, Everhart J. Decreasing seroprevalence of Helicobacter pylori infection in US children aged 6-19 years. J Pediatr Gastroenterol Nutr 2003;37:360.
21. Chiba N, Van Zanten SJ, Sinclair P, Ferguson RA, Escobedo S, Grace E. Treating Helicobacter pylori infection in primary care patients with uninvestigated dyspepsia: The Canadian adult dyspepsia empiric treatment-Helicobacter pylori positive (CADET-Hp) randomised controlled trial. BMJ 2002;324:1012-6.
22. Hassall E, Dimmick JE. Unique features of Helicobacter pylori disease in children. Dig Dis Sci 1991;36:417-23.
23. Apley J, Naish N. Recurrent abdominal pains: A field survey of 1,000 school children. Arch Dis Child 1958;33:165-70.
24. Thiessen PN. Recurrent abdominal pain. Pediatr Rev 2002;23:39-46.
25. Macarthur C, Saunders N, Feldman W. Helicobacter pylori, gastroduodenal disease, and recurrent abdominal pain in children. JAMA 1995;273:729-34.
26. Macarthur C. Helicobacter pylori infection and childhood recurrent abdominal pain: Lack of evidence for a cause and effect relationship. Can J Gastroenterol 1999;13:607-10.
27. Van der Meer SB, Forget PP, Loffeld RJ, Stobberingh E, Kuijten RH, Arends JW. The prevalence of Helicobacter pylori serum antibodies in children with recurrent abdominal pain. Eur J Pediatr 1992;151:799-801.
28. McCallion WA, Bailie AG, Ardill JE, Bamford KB, Potts SR, Boston VE. Helicobacter pylori, hypergastrinemia, and recurrent abdominal pain in children. J Pediatr Surg 1995;30:427-9.
29. Chong SK, Lou Q, Asnicar MA, et al. Helicobacter pylori infection in recurrent abdominal pain in childhood: Comparison of diagnostic tests and therapy. Pediatrics 1995;96:211-5.
30. Bode G, Rothenbacher D, Brenner H, Adler G. Helicobacter pylori and abdominal symptoms: A population based study among preschool children in southern Germany. Pediatrics 1998;101:634-7.
31. O'Donohoe JM, Sullivan PB, Scott R, Rogers T, Bruteton MJ, Barltrop D. Recurrent abdominal pain and Helicobacter pylori in a community-based sample of London children. Acta Paediatr 1996;85:961-4.
32. Hardikar W, Feekery C, Smith A, Oberklaid F, Grimwood K. Helicobacter pylori and recurrent abdominal pain in children. J Pediatr Gastroenterol Nutr 1996;22:148-52.
33. Sherman PM, Macarthur C. Current controversies associated with Helicobacter pylori infection in the pediatric population. Front Biosci 2001;6:E187-92.
34. Ashorn M, Rago T, Kokkonen J, Ruuska T, Rautelin H, Karikoski R. Symptomatic response to Helicobacter pylori eradication in children with recurrent abdominal pain: Double blind randomized placebo-controlled trial. J Clin Gastroenterol 2004;38:646-50.
35. Nelson SP, Chen EH, Syniar GM, Christoffel KK. Prevalence of symptoms of gastroesophageal reflux during childhood: A pediatric practice-based survey. Pediatric Practice Research Group. Arch Pediatr Adolesc Med 2000;154:150-4.
36. Gold BD, Bulens S, Guarner J, et al. Helicobacter pylori and gastroesophageal reflux disease (GERD): There is a relationship - the pediatric perspective, abstracted (#2610). Gastroenterology 2000;118:A483. (Abst)
37. Rosioru C, Glassman MS, Halata MS, Schwarz SM. Esophagitis and Helicobacter pylori in children: Incidence and therapeutic implications. Am J Gastroenterol 1993;88:510-3.
38. Levine A, Milo T, Broide E, et al. Influence of Helicobacter pylori eradication on gastroesophageal reflux symptoms and epigastric pain in children and adolescents. Pediatrics 2004;113:54-8.
39. Pollet S, Gottrand F, Vincent P, et al. Gastroesophageal reflux disease and Helicobacter pylori infection in neurologically impaired children: Inter-relations and therapeutic implications. J Pediatr Gastroenterol Nutr 2004;38:70-4.
40. Moayyedi P, Bardhan C, Young L, Dixon MF, Brown L, Axon AT. Helicobacter pylori eradication does not exacerbate reflux symptoms in gastroesophageal reflux disease. Gastroenterology 2001; 121:1120-6.
41. Harvey RF, Lane JA, Murray LJ, Harvey IM, Donovan JL, Nair P; Bristol Helicobacter Project. Randomised controlled trial of effects of Helicobacter pylori infection and its eradication on heartburn and gastro-oesophageal reflux: Bristol helicobacter project. BMJ 2004;328:1417.
42. Kuipers EJ, Lundell L, Klinkenberg-Knol EC, et al. Atrophic gastritis and Helicobacter pylori infection in patients with reflux esophagitis treated with omeprazole or fundoplication. N Engl J Med 1996;334:1018-22.
43. Lundell L, Miettinen P, Myrvold HE, et al. Lack of effect of acid suppression therapy on gastric atrophy. Gastroenterology 1999;117:319-26.
44. Vigneri S, Termini R, Scialabba A, Pisciotta G, Di Mario F. Omeprazole therapy modifies the gastric localization of Helicobacter pylori. Am J Gastroenterol 1991;86:1276.
45. Graham DY, Opekun AR, Yamaoka Y, Osato MS, el-Zimaity HM. Early events in proton pump inhibitor-associated exacerbation of corpus gastritis. Aliment Pharmacol Ther 2003;17:193-200.
46. Kuipers EJ, Nelis GF, Klinkenberg-Knol EC, et al. Cure of Helicobacter pylori infection in patients with reflux oesophagitis treated with long term omeprazole reverses gastritis without exacerbation of reflux disease: Results of a randomised controlled trial. Gut 2004;53:12-20.
47. Takahashi M, Kimura H, Watanabe K. Helicobacter pylori infection in patients with idiopathic short stature. Pediatr Int 2002;44:277-80.
48. Passaro DJ, Taylor DN, Gilman RH, Cabrera L, Parsonnet J. Growth slowing after acute Helicobacter pylori infection is age-dependent. J Pediatr Gastroenterol Nutr 2002;35:522-6.
49. Thomas JE, Dale A, Bunn JE, et al. Early Helicobacter pylori colonisation: The association with growth faltering in The Gambia. Arch Dis Child 2004;89:1149-54.
50. Sato R, Murakami K, Watanabe K, et al. Effect of Helicobacter pylori eradication on platelet recovery in patients with chronic idiopathic thrombocytopenic purpura. Arch Intern Med 2004;164:1904-7.
51. Jaing TH, Yang CP, Hung IJ, Chiu CH, Chang KW. Efficacy of Helicobacter pylori eradication on platelet recovery in children with chronic idiopathic thrombocytopenic purpura. Acta Paediatr 2003;92:1153-7.
52. Barabino A. Helicobacter pylori-related iron deficiency anemia: A review. Helicobacter 2002;7:71-5.
53. Choe YH, Kwon YS, Jung MK, Kang SK, Hwang TS, Hong YC. Helicobacter pylori-associated iron-deficiency anemia in adolescent female athletes. J Pediatr 2001;139:100-4.
54. Dhaenens L, Szczebara F, Husson MO. Identification, characterization, and immunogenicity of the lactoferrin-binding protein from Helicobacter pylori. Infect Immun 1997;65:514-8.
55. Velayudhan J, Hughes NJ, McColm AA, et al. Iron acquisition and virulence in Helicobacter pylori: A major role for FeoB, a high-affinity ferrous iron transporter. Mol Microbiol 2000;37:274-86.
56. Bahu Mda G, da Silveira TR, Maguilnick I, Ulbrich-Kulczynski J. Endoscopic nodular gastritis: An endoscopic indicator of high-grade bacterial colonization and severe gastritis in children with Helicobacter pylori. J Pediatr Gastroenterol Nutr 2003;36:217-22.
57. Elitsur Y, Lawrence Z, Triest WE. Distribution of Helicobacter pylori organisms in the stomachs of children with H pylori infection. Hum Pathol 2002;33:1133-5.
58. Borrelli O, Hassall E, Cucchiara S, et al. Inflammation of the gastric cardia in children with symptoms of acid peptic disease. J Pediatr 2003;143:520-4.
59. Logan RP, Walker MM, Misiewicz JJ, Gummett PA, Karim QN, Baron JH. Changes in the intragastric distribution of Helicobacter pylori during treatment with omeprazole. Gut 1995;36:12-6.
60. Rotimi O, Cairns A, Gray S, et al. Histological identification of Helicobacter pylori: Comparison of staining methods. J Clin Pathol 2000;53:756-9.
61. Leong RW, Lee CC, Ling TK, et al. Evaluation of the string test for the detection of Helicobacter pylori. World J Gastroenterol 2003;9:309-11.
62. el-Zaatari FA, Oweis SM, Graham DY. Uses and cautions for use of polymerase chain reaction for detection of Helicobacter pylori. Dig Dis Sci 1997;42:2116-9.
63. Vaira D, Vakil N. Blood, urine, stool, breath, money and Helicobacter pylori. Gut 2001;48:287-9.
64. Elitsur Y, Neace C. Detection of Helicobacter pylori organisms by Hp-fast in children. Dig Dis Sci 1999;44:1169-72.
65. Jones NL, Bourke B, Sherman PM. Breath testing for Helicobacter pylori infection in children: A breath of fresh air? J Pediatr 1997;131:791-3.
66. Rowland M, Lambert I, Gormally S, et al. Carbon 13-labeled urea breath test for the diagnosis of Helicobacter pylori infection in children. J Pediatr 1997;131:815-20.
67. Graham DY, Runke D, Anderson SY, Malatay HM, Klein PD. Citric acid as the test meal for the 13C-urea breath test. Am J Gastroenterol 1999;94:1214-7.
68. Megraud F; European Paediatric Task Force on Helicobacter pylori. Comparison of non-invasive tests to detect Helicobacter pylori infection in children and adolescents: Results of a multicenter European study. J Pediatr 2005;146:198-203.
69. 13C-urea breath test results in children. J Pediatr Gastroenterol Nutr 2000;30:85-91. (Erratum in 2000;30:354).
70. Imrie C, Rowland M, Bourke B, Drumm B. Limitations to carbon 13-labeled urea breath testing for Helicobacter pylori in infants. J Pediatr 2001;139:734-7.
71. Koletzko S, Feydt-Schmidt A. Infants differ from teenagers: Use of non-invasive tests for detection of Helicobacter pylori infection in children. Eur J Gastroenterol Hepatol 2001;13:1047-52
72. 2 production rates in children. J Pediatr Gastroenterol Nutr 1999; 29:297-301.
73. Leung WK, Hung LC, Kwok CK, Leong RW, Ng DK, Sung JJ. Follow up of serial urea breath test results in patients after consumption of antibiotics for non-gastric infections. World J Gastroenterol 2002;8:703-6.
74. Graham DY, Opekun AR, Hammoud F, et al. Studies regarding the mechanism of false negative urea breath tests with proton pump inhibitors. Am J Gastroenterol 2003;98:1005-9.
75. Laine L, Estrada R, Trujillo M, Knigge K, Fennerty MB. Effect of proton-pump inhibitor therapy on diagnostic testing for Helicobacter pylori. Ann Intern Med 1998;129:547-50.
76. Ni YH, Lin JT, Huang SF, Yang JC, Chang MH. Accurate diagnosis of Helicobacter pylori infection by stool antigen test and 6 other currently available tests in children. J Pediatr 2000;136:823-7.
77. Konstantopoulos N, Russmann H, Tasch C, et al. Evaluation of the Helicobacter pylori stool antigen test (HpSA) for detection of Helicobacter pylori infection in children. Am J Gastroenterol 2001;96:677-83.
78. van Doorn OJ, Bosnian DK, van't Hoff BW, Taminiau JA, ten Kate FJ, van der Ende A. Helicobacter pylori Stool Antigen test: A reliable non-invasive test for the diagnosis of Helicobacter pylori infection in children. Eur J Gastroenterol Hepatol 2001; 13:1061-5.
79. Oderda G, Rapa A, Ronchi B, et al. Detection of Helicobacter pylori in stool specimens by non-invasive antigen enzyme immunoassay in children: Multicentre Italian study. BMJ 2000; 320:347-8.
80. Koletzko S, Konstantopoulos N, Bosman D, et al. Evaluation of a novel monoclonal enzyme immunoassay for detection of Helicobacter pylori antigen in stool from children. Gut 2003;52:804-6.
81. Khanna B, Cutler A, Israel NR, et al. Use caution with serologic testing for Helicobacter pylori infection in children. J Infect Dis 1998;178:460-5.
82. Kindermann A, Konstantopoulos N, Lehn N, Demmelmair H, Koletzko S. Evaluation of two commercial enzyme immunoassays, testing immunoglobulin G (IgG) and IgA responses, for diagnosis of Helicobacter pylori infection in children. J Clin Microbiol 2001;39:3591-6.
83. de Oliveira AM, Rocha GA, Queiroz DM, et al. Evaluation of enzyme-linked immunosorbent assay for the diagnosis of Helicobacter pylori infection in children from different age groups with and without duodenal ulcer. J Pediatr Gastroenterol Nutr 1999;28:157-61.
84. Czinn SJ. Serodiagnosis of Helicobacter pylori in pediatric patients. J Pediatr Gastroenterol Nutr 1999;28:132-4.
85. Gottrand F, Kalach N, Spyckerelle C, et al. Omeprazole combined with amoxycillin and clarithromycin in the eradication of Helicobacter pylori in children with gastritis: A prospective randomized double-blind trial. J Pediatr 2001;139:664-8.
86. Cammarota G, Cianci R, Cannizzaro O, et al. High-dose versus low-dose clarithromycin in 1-week triple therapy, including rabeprazole and levofloxacin, for Helicobacter pylori eradication. J Clin Gastroenterol 2004;38:110-4.
87. Perri F, Festa V, Merla A, Barberani F, Pilotto A, Andriulli A. Randomized study of different 'second-line' therapies for Helicobacter pylori infection after failure of the standard 'Maastricht triple therapy'. Aliment Pharmacol Ther 2003;18:815-20.
88. Nista EC, Candelli M, Cremonini F, et al. Levofloxacin-based triple therapy vs quadruple therapy in second-line Helicobacter pylori treatment: A randomized trial. Aliment Pharmacol Ther 2003; 18:627-33.
89. Calvet X, Garcia N, Lopez T, Gisbert JP, Gene E, Roque M. A meta-analysis of short versus long therapy with a proton pump inhibitor, clarithromycin and either metronidazole or amoxycillin for treating Helicobacter pylori infection. Aliment Pharmacol Ther 2000; 14:603-9.
90. Oderda G, Rapa A, Bona G. A systematic review of Helicobacter pylori eradication treatment schedules in children. Aliment Pharmacol Ther 2000;14(Suppl 3):59-66.
91. Fallone CA. Epidemiology of the antibiotic resistance of Helicobacter pylori in Canada. Can J Gastroenterol 2000;14:879-82.
92. Megraud F. H pylori antibiotic resistance: Prevalence, importance, and advances in testing. Gut 2004;53:1374-84.
93. Duck WM, Sobel J, Pruckler JM, et al. Antimicrobial resistance incidence and risk factors among Helicobacter pylori-infected persons, United States. Emerg Infect Dis 2004; 10:1088-94.