Eflornithine is safer than melarsoprol for the treatment of second-stage Trypanosoma brucei gambiense human African trypanosomiasis

Clinical Infectious Diseases

Volumn 41, Issue 5, 2005, Pages 748-751

  Chappuis, François ^a   Udayraj, Nitya ^a   Stietenroth, Kai ^a   Meussen, Ann ^a   Bovier, Patrick A ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EFLORNITHINE; MELARSOPROL;

ADOLESCENT; ADULT; AFRICAN TRYPANOSOMIASIS; AGED; ARTICLE; BRAIN DISEASE; CHILD; DIARRHEA; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; FEMALE; FEVER; HEADACHE; HUMAN; HYPERTENSION; HYPOTENSION; JAUNDICE; MAJOR CLINICAL STUDY; MALE; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; RASH; RECIPIENT; SIDE EFFECT; SUDAN; TREMOR; TRYPANOSOMA BRUCEI;

ADOLESCENT; ADULT; CHILD; EFLORNITHINE; FEMALE; HUMANS; MALE; MELARSOPROL; SUDAN; TRYPANOCIDAL AGENTS; TRYPANOSOMIASIS, AFRICAN;

EID: 23844449378     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/432576     Document Type: Article

References (10)

1. World Health Organization. Control and surveillance of African trypanosomiasis: report of a WHO expert committee. WHO technical report series 881. Geneva: World Health Organization, 1998.
2. Brun R, Schumacher R, Schmid C, Kunz C, Burri C. The phenomenon of treatment failures in human African trypanosomiasis. Trop Med Int Health 2001; 6:906-14.
3. Pépin J, Khonde N, Maiso F, et al. Short-course eflornithine in Gambian trypanosomiasis: a multicentre randomized controlled trial. Bull WHO 2000; 78:1284-95.
4. Milord F, Pépin J, Loko L, Ethier L, Mpia B. Efficacy and toxicity of eflornithine for treatment of Trypanosoma brucei gambiense sleeping sickness. Lancet 1992; 340:652-5.
5. Milord F, Loko L, Ethier L, Mpia B, Pépin J. Eflornithine concentration in serum and cerebrospinal fluid of 63 patients treated for Trypanosoma brucei gambiense sleeping sickness. Trans Roy Soc Trop Med Hyg 1993; 87:473-7.
6. Chappuis F, Pittet A, Bovier PA, et al. Field evaluation of the CATT/Trypanosoma brucei gambiense on blood-impregnated filter papers for diagnosis of human African trypanosomiasis in southern Sudan. Trop Med Int Health 2002; 11:942-8.
7. Schmid C, Nkunku S, Merolle A, Vounatsou P, Burri C. Efficacy of 10-day melarsoprol schedule 2 years after treatment for late-stage gambiense sleeping sickness. Lancet 2004; 364:789-90.
8. Pépin J. African trypanosomiasis. In: Strickland GT, eds. Hunter's tropical medicine and emerging infectious diseases. 8th ed. Philadelphia: WB. Saunders, 2000:643-53.
9. Chappuis F. Eflornithine for the treatment of human African trypanosomiasis, practical perspectives. Développement et Santé 2004; 171:41-7.
10. Legros D, Ollivier G, Gastellu-Etchegorry M, et al. Treatment of human African trypanosomiasis-present situation and needs for research and development. Lancet Infect Dis 2002; 2:437-40.