Proposed mechanisms and preventative options of Jarisch-Herxheimer reactions

Journal of Clinical Pharmacy and Therapeutics

Volumn 30, Issue 3, 2005, Pages 291-295

  Pound, Melanie W ^a,b   May, D B ^a,c  

^a Campbell University   (United States)

^b Cape Fear Valley Health System Cancer Center   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Antibiotics; Cytokines; Endotoxin; Jarisch Herxheimer reactions; Spirochete

Indexed keywords

ALUMINUM DERIVATIVE; ANTIBIOTIC AGENT; ANTIHISTAMINIC AGENT; BETA LACTAM ANTIBIOTIC; CEFUROXIME; CORTICOSTEROID; CYTOKINE; DOXYCYCLINE; ENDOTOXIN; ERYTHROMYCIN; HYDROCORTISONE; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; MEPTAZINOL; NALOXONE; PARACETAMOL; PENTOXIFYLLINE; PLACEBO; PREDNISOLONE; PROCAINE PENICILLIN; TETRACYCLINE; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; ANTIINFECTIVE AGENT;

ARTHRALGIA; BACTERIAL INFECTION; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG EFFICACY; ESCHERICHIA COLI; FEVER; HEADACHE; HERXHEIMER REACTION; HUMAN; INCIDENCE; KLEBSIELLA; LYME DISEASE; REVIEW; SLOW RELEASE FORMULATION; DRUG EFFECT; DRUG HYPERSENSITIVITY; IMMUNOLOGY; METABOLISM; SPIROCHETE; SPIROCHETE INFECTION;

ANTI-BACTERIAL AGENTS; CYTOKINES; DRUG HYPERSENSITIVITY; ENDOTOXINS; HUMANS; SPIROCHAETALES; SPIROCHAETALES INFECTIONS;

EID: 23844441705     PISSN: 02694727     EISSN: 13652710     Source Type: Journal    
DOI: 10.1111/j.1365-2710.2005.00631.x     Document Type: Review

References (28)

1. Jarisch, A (1895) Therapeutische versuche bei syphilis. Wiener Medizinische Wochenschrift, 45, 721-724.
2. Herxheimer, K, Krause DW (1902) Ueber eine bei syphilitischen vorkommende quecksilberraektion. Deutsche Medizinische Wochenschrift, 28, 895-897.
3. Meislin HW, Bremer JC (1976) Jarisch-Herxheimer reaction. Case report. Journal of the American College of Emergency Physicians, 5, 779-781.
4. Anonymous (1967) Jarisch-Herxheimer reaction. British Medical Journal, 1, 384.
5. Vaughan C, Cronin CC, Walsh EK, Whelton M (1994) The Jarisch-Herxheimer reaction in leptospirosis. Postgraduate Medical Journal, 70, 118-121.
6. Maloy AL, Black RD, Segurola RJ. Jr (1998) Lyme disease complicated by the Jarisch-Herxheimer reaction. Journal of Emergency Medicine, 16, 437-438.
7. Dworkin MS, Anderson DE. Jr, Schwan TG et al. (1998) Tick-borne relapsing fever in the north-western United States and southwestern Canada. Clinical Infectious Diseases, 26, 122-131.
8. Bryceson AD, Cooper KE, Warrell DA, Perine PL, Parry EH (1972) Studies of the mechanism of the Jarisch-Herxheimer reaction in louse-borne relapsing fever: evidence for the presence of circulating borrelia endotoxin. Clinical Science, 43, 343-354.
9. Gelfand JA, Elin RJ, Berry FW Jr, Frank MM (1976) Endotoxemia associated with the Jarisch-Herxheimer reaction. New England Journal of Medicine, 295, 211-213.
10. Young EJ, Weingarten NM, Baughn RE, Duncan WC (1982) Studies on the pathogenesis of the Jarisch-Herxheimer reaction: development of an animal model and evidence against a role for classical endotoxin. Journal of Infectious Diseases, 146, 606-615.
11. Negussie Y, Remick DG, DeForge LE, Kunkel SL, Eynon A, Griffin GE (1992) Detection of plasma tumor necrosis factor, interleukins 6, and 8 during the Jarisch-Herxheimer Reaction of relapsing fever. Journal of Experimental Medicine, 175, 1207-1212.
12. Fekade D, Knox K, Hussein K et al. (1996) Prevention of Jarisch-Herxheimer reactions by treatment with antibodies against tumor necrosis factor alpha. New England Journal of Medicine, 335, 311-315.
13. Galloway RE, Levin J, Butler T et al (1977) Activation of protein mediators of inflammation and evidence for endotoxemia in Borrelia recurrentis infection. American Journal of Medicine, 63, 933-938.
14. Hardy PH Jr, Levin J (1983) Lack of endotoxin in Borrelia hispanica and Treponema pallidum. Proceedings of the Society for Experimental Biology and Medicine, 174, 47-52.
15. Shenep JL, Feldman S, Thornton D (1986) Evaluation for endotoxemia in patients receiving penicillin therapy for secondary syphilis. JAMA, 256, 388-390.
16. Radolf JD, Norgard MV, Brandt ME, Isaacs RD, Thompson PA, Beutler B (1991) Lipoproteins of Borrelia burgdorferi and Treponema pallidum activate cachectin/tumor necrosis factor synthesis. Analysis using a CAT reporter construct. Journal of Immunology, 147, 1968-1974.
17. Elin RJ, Robinson RA, Levine AS et al. (1975) Lack of clinical usefulness of the limulus test in the diagnosis of endotoxemia. New England Journal of Medicine, 293, 521-524.
18. Elin RJ, Wolff SM (1973) Nonspecificity of the limulus amebocyte lysate test: positive reactions with polynucleotides and proteins. Journal of Infectious Diseases, 128, 349-352.
19. Griffin GE (1998) Cytokines involved in human septic shock - the model of the Jarisch-Herxheimer reaction. Journal of Antimicrobial Chemotherapy, 41 (Suppl. A), 25-29.
20. Nadelman RB, Luger SW, Frank E, Wisniewski M, Collins JJ, Wormser GP (1992) Comparison of cefuroxime axetil and doxycycline in the treatment of early Lyme disease. Annals of Internal Medicine, 117, 273-280.
21. Butler T, Jones PK, Wallace CK (1978) Borrelia recurrentis infection: single-dose antibiotic regimens and management of the Jarisch-Herxheimer reaction. Journal of Infectious Diseases, 137, 573-577.
22. Gebrehiwot T, Fiseha A (1992) Tetracycline versus penicillin in the treatment of louse-borne relapsing fever. Ethiopian Medical Journal, 30, 175-181.
23. Warrell DA, Perine PL, Krause DW, Bing DH, MacDougal SJ (1983) Pathophysiology and immunology of the Jarisch-Herxheimer-like reaction in louse-borne relapsing fever: comparison of tetracycline and slow-release penicillin. Journal of Infectious Diseases, 147, 898-909.
24. Cooper PJ, Fekade D, Remick DG, Grint P, Wherry J, Griffin GE (2000) Recombinant human interleukin-10 fails to alter proinflammatory cytokine production or physiologic changes associated with the Jarisch-Herxheimer reaction. Journal of Infectious Diseases, 181, 203-209.
25. Remick DG, Negussie Y, Fekade D, Griffin G (1986) Pentoxifylline fails to prevent the Jarisch-Herxheimer reaction or associated cytokine release. Journal of Infectious Diseases, 174, 627-630.
26. Gudjonsson H, Skog E (1968) The effect of prednisolone on the Jarisch-Herxheimer reaction. Acta Dermato-Venereologica, 48, 15-18.
27. Teklu B, Habte-Michael A, Warrell DA, White NJ, Wright DJ (1983) Meptazinol diminishes the Jarisch-Herxheimer reaction of relapsing fever. Lancet, 1, 835-839.
28. Rosen T, Rubin H, Ellner K, Tschen J, Cochran R (1989) Vesicular Jarisch-Herxheimer reaction. Archives of Dermatology, 125, 77-81.