Novel delivery of oligonucleotides using a topical hydrogel tissue sealant in a murine partial nephrectomy model

Journal of Urology

Volumn 174, Issue 3, 2005, Pages 1133-1136

  Ramakumar, Sanjay ^a   Phull, Hardeep ^a   Purves, Todd ^a   Funk, Joel ^a   Copeland, Duan ^a   Ulreich, Judith B ^a   Lai, Li Wen ^a   Lien, Yeong Hau Howard ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Hydrogel; Kidney; Mice; Nephrectomy; Oligonucleotides

Indexed keywords

MACROGOL; OLIGONUCLEOTIDE; SEALANT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; FLUORESCENCE MICROSCOPY; GENE THERAPY; HEMOSTASIS; HYDROGEL; KIDNEY CORTEX; KIDNEY INJURY; MALE; MOUSE; NONHUMAN; PARTIAL NEPHRECTOMY; POLYMERIZATION; PRIORITY JOURNAL; REPERFUSION INJURY; TISSUE SPECIFICITY;

EID: 23744508422     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ju.0000168617.17080.46     Document Type: Article

References (13)

1. Dragun, D., Tulius, S. G., Park, J. K., Maasch, C., Lukitsch, I., Lippoldt, A. et al: ICAM-1 antisense oligodeoxynucleotides prevent reperfusion injury and enhance immediate graft function in renal transplantation. Kidney Int, 54: 590, 1998
2. Lien Y. H. and Lai, L. W.: Renal gene transfer: nonviral approaches. Mol Biotech, 24: 283, 2003
3. Butler, M., Stecker, K. and Bennett, C. F.: Cellular distribution of phosphothioate oligodeoxynucleotides in normal rodent tissues. Lab Invest, 77: 379, 1997
4. Park, E. L., Ulreich, J. B., Scott, K. M., Ullrich, N. P. F., Linehan, J. A., French, M. H. et al: Evaluation of polyethylene glycol based hydrogel for tissue sealing after laparoscopic partial nephrectomy in a porcine model. J Urol, 172: 2446, 2004
5. Kelly, K. J., Williams, W. W., Jr., Colvin, R. B., Meehan, S. M., Springer, T. A., Gutierrez-Ramos, J. C. et al: Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury. J Clin Invest, 97: 1056, 1996
6. Lien, Y. H., Lai, L. and Silva, A. L.: Pathogenesis of hypoxia-induced cellular injury: lessons from knock out mice. Life Sci, 74: 543, 2003
7. Hanss, B., Leal-Pinto, E., Bruggeman, L. A., Copeland, T. D. and Klotman, P. E.: Identification and characterization of a cell membrane nucleic acid channel. Proc Natl Acad Sci USA, 95: 1921, 1998
8. Beltinger, C., Saragovi, H. U., Smith, R. M., LeSauteur, L., Shah, N. DeDionisio, L. et al: Binding, uptake, and intracellular trafficking of phosphorothioate-modified oligodeoxynucleotides. J Clin Invest, 95: 1814, 1995
9. Oberbauer, R., Schreiner, G. F., Biber, J., Murer, H. and Meyer, T. W.: In vivo suppression of the renal na+/pi cotransporter by antisense oligonucleotides. Proc Natl Acad Sci USA, 93: 4903, 1996
10. Lai, L. W., Chan, D. M., Erickson, R. P., Hsu, S. J. and Lien, Y. H.: Correction of renal tubular acidosis in carbonic anhydrase II-deficient mice with gene therapy. J Clin Invest, 101: 1320, 1998
11. Haller, H., Maasch, C., Dragun, D., Wellner, M., von Janta-Lipinski, M. and Luft, F. C.: Antisense oligodesoxynucleotide strategies in renal and cardiovascular disease. Kidney Int, 53: 1550, 1998
12. Chen, W., Bennett, C. F., Wang, M. E., Dragun, D., Tian, L., Stecker, K. et al: Perfusion of kidneys with unformulated "naked" intercellular adhesion molecule-1 antisense oligodeoxynucleotides prevents ischemic/reperfusion injury. Transplantation, 68: 880, 1999
13. Stepkowski, S. M., Wang, M. E., Condon, T. P., Cheng-Flournoy, S., Stecker, K., Graham, M. et al: Protection against allograft rejection with intracellular adhesion molecule-1 antisense oligodeoxynucleotides. Transplantation, 66: 699, 1998