The horse and high altitude

Clinical Techniques in Equine Practice

Volumn 2, Issue 3, 2003, Pages 231-237

  Wickler, Steven J ^a   Greene, Holly M ^a  

^a CALIFORNIA STATE POLYTECHNIC UNIVERSITY   (United States)

Author keywords

2,3 diphosphoglycerate; HAPE; Hypoxemia; Mules

Indexed keywords

EQUIDAE; EQUUS CABALLUS;

EID: 23744502677     PISSN: 15347516     EISSN: None     Source Type: Journal    
DOI: 10.1053/S1534-7516(03)00066-0     Document Type: Article

References (45)

1. Lenfant C, Sullivan K: Adaptation to high altitude. N Engl J Med 284:1298-1309, 1971
2. Winslow R: Red cell function at extreme altitude, in West J, Lahiri S (eds): High Altitude and Man, Waverly Press, Baltimore, MD, p 59, 1984
3. Winslow R, Samaja M, West J: Red cell function at extreme altitudes on Mount Everest. J Appl Physiol 56:109-116, 1984
4. de Aluja A, Gross D, McCoker P, et al: Effect of altitude on horses. Vet Rec 82:368-373, 1968
5. Collins J, Farrelly B, Byrne M: Changes in the number and quality of erythrocytes in horses transported to high altitudes. Irish Vet J 23:42-46, 1969
6. Persson S: On blood volume and working capacity. Acta Vet Scand Suppl 19:1-189, 1967
7. Archer R, Clabby J: The effect of excitation and exertion on the circulating blood of horses. Vet Rec 77:689-692, 1965
8. Greene H, Cogger E, Miltenberger T, et al: Metabolic and osmoregulatory function at low and high (3800 m) altitude. Equine Vet J Suppl 34:545-550, 2002
9. Wickler S, Anderson T: Hematological changes and athletic performance in horses in response to high altitude (3,800 m). Am J Physiol Regul lntegr Comp Physiol 279:R1176-R1181, 2000
10. Smith T, Beam W, Wickler S, et al: Altitude not exercise increase plasma erythropoietin in the horse. FASEB J 12:A724, 1998
11. Lenfant C, Torrance J, English E, et al: Effects of altitude on oxygen binding by hemoglobin and on organic phosphate levels. J Clin Invest 47:2652-2656, 1968
12. Samaja M, Di Prampero P, Cerretelli P: The role of 2,3-DPG in oxygen transport at altitude. Respir Physiol 64:191-202, 1986
13. Wagner P, Gillespie J, Landgren G, et al: Mechanism of exercise-induced hypoxemia in horses. J Appl Physiol 66:1227-1233, 1989
14. Saltin B, Kim C, Terrados N, et al: Morphology enzyme activities and buffer capacity in leg muscles of Kenyan and Scandinavian runners. Scand J Med Sci Sports 5:222-230, 1995
15. Terblanche S, Groenewald J, Van Der Linder A, et al: A comparative study on the effect of training at altitude and at sea level on endurance and certain biochemical variables. Comp Biochem Physiol 78A:21-26, 1984
16. Green H, Sutton J, Wolfel E, et al: Altitude acclimatization and energy metabolism adaptations in skeletal muscle during exercise. J Appl Physiol 73:2701-2708, 1992
17. van Hall G, Sander M, Calbet J, et al: Regulation of glycogenolysis during exercise at 4100m in high-altitude natives and lowlanders in the course of acclimatization. FASEB J 17:A1284, 2003
18. Greene H, Wickler S: Acute altitude exposure (3800 meters) and metabolic capacity in the middle gluteal muscle of equids. J Equine Vet Sci 20:175-178, 2000
19. Greene H, Wickler S, Anderson T, et al: High-altitude effects on respiratory gases, acid-base balance and pulmonary artery pressures in equids. Equine Vet J Suppl 30:71-76, 1999
20. Bisgard G, Orr J, Will J: Hypoxic pulmonary hypertension in the pony. Am J vet Res 36:49-52, 1975
21. Orr J, Bisgard E, Forster H, et al: Cerebrospinal fluid alkalosis during high-altitude sojourn in unanesthetized ponies. Respir Physiol 25:23-37, 1975
22. Kronenberg R, Safar P, Lee J, et al: Pulmonary artery pressure and alveolar gas exchange in man during acclimatisation to 12,400 ft. J Clin Invest 50:827-837, 1971
23. Hannon J, Vogel J: Oxygen transport during early altitude acclimatisation: a perspective study. Eur J Appl Physiol 36:285-297, 1977
24. Hansen J, Stelter G, Vogel J: Arterial pyruvate, lactate, pH and pCO2 during work at sea level and high altitude. J Appl Physiol 23:523-530, 1967
25. Grover R, Reeves J, Will D, et al: Pulmonary vasoconstriction in steers at high altitude. J Appl Physiol 18:567-574, 1963
26. Hultgren H, Spickard W: Medical experiences in Peru. Stanford Medical Bulletin 18:76-95, 1960
27. Roberts A, Buttefield G, Cymerman A, et al: Acclimatization to 4,300-m altitude decreases reliance on fat as a substrate. Appl Physiol 84:1762-1771, 1996
28. Humpeler E, Skrabal R, Bartsch G: Influence of exposure to moderate altitude on the plasma concentration of cortisol, aldosterone, renin, testosterone and gonadotropins. Eur J Appl Physiol 45:167-176, 1980
29. Sawhney R, Malhotra A, Singh T, et al: Insulin secretion at high altitude in man. Int J Biometeor 30:231-238, 1986
30. Wickler S, Pauley P, Bray R, et al: Performance at high altitude of horses and mules receiving fat supplemented diets. Equine Vet J Suppl 18:406-409, 1995
31. Calbet J, Boushel R, Rådegran G, et al: Why is VO2max after altitude acclimatization still reduced despite normalization of arterial O2 content? Am J Physiol Regul Integr Comp Physiol 284:R304-R316, 2003
32. Moore L, Brewer G: Beneficial effect of rightward hemoglobin-oxygen dissociation curve shift for short-term altitude adaptation. J Lab Clin Med 98:145-154, 1981
33. Wickler S, Troy W: Blood volume, lactate and cortisol in exercising Arabian equitation horses, in Persson S, Lindholm A, Jeffcott LB (eds): Equine Exercise Physiology 3. Davis, CA, ICEEP, pp 397-401, 1991
34. Banchero N: Capillary density of skeletal muscle in dogs exposed to simulated altitude. Proc Soc Exp Biol Med 148:435-439, 1975
35. Bigard A, Brunet A, Guezennec C, et al: Skeletal muscle changes after endurance training at high altitude. J Appl Physiol 71:2114-2121, 1991
36. Levine B, Stray-Gundersen J: Living high training low: effect of moderate-altitude acclimatization with low altitude training on performance. J Appl Physiol 83:102-112, 1997
37. Riar S, Saxena R, Sen Gupta J, et al: Changes in the physiological responses in mules on induction to high altitude. Indian Vet J 53:83-90, 1976
38. Tucker R, Wickler S, London C, et al: Echocardiographic and right-sided cardiac pressure comparison of the mule and horse. J Equine Vet Sci 15:404-408, 1995
39. Hurson M, Greene H, Szewczak J, et al: 2,3-DPG changes in horses, mules and burros with exposure to altitude. Physiologist 45:376, 2002
40. Kolb E: The metabolism of iron in farm animals under normal and pathologic condition. Adv Vet Sci Comp Med 8:49-114, 1963
41. Greene H, Wickler S, Tucker R, et al: Fiber type composition of the middle gluteal muscle of mules. J Equine Vet Sci 15:388-390, 1995
42. Hill E, Greene H, Wickler S, et al: Hematological responses to high-altitude exposure (3800 m) in donkeys. Proc Equine Nutr Physiol Soc (17th) 440-441, 2001
43. Liberatore G, Wickler S, Greene H: Effect of acute altitude exposure (3800 meters) on the metabolic capacity of the middle gluteal muscle of the donkey (Equus asinus). Proc Equine Nutr Physiol Soc (17th) 337-382, 2001
44. Greene H, Wickler S, Cogger E, et al: High altitude (3800 m) effects on pH, pCO2, pO2, and pulmonary artery pressures in the donkey. Proc Equine Nutr Physiol Soc (17th) 253-254, 2001
45. Langsetmo I, Weigle G, Fedde M, et al: VO2 kinetics in the horse during moderate and heavy exercise. J Appl Physiol 83:1235-1241, 1997