A noninvasive oral rinse assay to monitor engraftment, neutrophil tissue delivery and susceptibility to infection following HSCT in pediatric patients

Bone Marrow Transplantation

Volumn 36, Issue 3, 2005, Pages 227-232

  Cheretakis, C ^a   Dror, Y ^b   Glogauer, Michael ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Hematopoietic stem cell transplantation; Neutrophil; Oral rinse

Indexed keywords

CYCLOSPORIN; FLUDARABINE; METHOTREXATE; MYELOABLATIVE AGENT;

ADOLESCENT; ADULT; ARTICLE; BLOOD CELL COUNT; BONE MARROW DISEASE; CELL TRANSPORT; CHILD; CLINICAL ARTICLE; FEMALE; FEVER; GRAFT SURVIVAL; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; INFECTION SENSITIVITY; LEUKEMIA; LYMPHOMA; MALE; MOUTH MUCOSA; MYELOABLATIVE CONDITIONING; NEUTROPHIL; NON INVASIVE MEASUREMENT; PRIORITY JOURNAL; REDUCED INTENSITY CONDITIONING; STOMATITIS; TIME; TRANSPORT KINETICS;

ADOLESCENT; ADULT; CHILD; DISEASE SUSCEPTIBILITY; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; INFECTION; KINETICS; LEUKEMIA; LEUKOCYTE COUNT; MALE; MICROSCOPY, FLUORESCENCE; MOUTH MUCOSA; MOUTHWASHES; NEUTROPHILS; TIME FACTORS;

EID: 23744501551     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1705025     Document Type: Article

References (11)

1. Ali MY, Oyama Y, Monreal J et al. Reassessing the definition of myeloid engraftment after autotransplantation: it is not necessary to see 0.5 × 10(9)/l neutrophils on 3 consecutive days to define myeloid recovery. Bone Marrow Transplant 2002; 30: 749-752.
2. Laughlin MJ, Barker J, Bambach B et al. Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. N Engl J Med 2001; 344: 1815-1822.
3. Mehta J, Powles R, Singhal S et al. Early identification of patients at risk of death due to infections, hemorrhage, or graft failure after allogeneic bone marrow transplantation on the basis of the leukocyte counts. Bone Marrow Transplant 1997; 19: 349-355.
4. Madero L, Diaz MA, Ortega JJ et al. Recombinant human granulocyte-macrophage colony-stimulating factor accelerates engraftment kinetics after allogeneic bone marrow transplantation for childhood acute lymphoblastic leukemia. Haematologica 1999; 84: 133-137.
5. Zimmerli W, Zarth A, Gratwohl A, Speck B. Neutrophil function and pyogenic infections in bone marrow transplant recipients. Blood 1991; 77: 393-399.
6. Wright DG, Meierovics AI, Foxley JM. Assessing the delivery of neutrophils to tissues in neutropenia. Blood 1986; 67: 1023-1030.
7. Raeste AM, Tapanila T, Tupakka R. Leukocyte migration into the healthy dentulous mouth. A study in children, adolescents and adults. J Periodontal Res 1977; 12: 444-449.
8. Ashkenazi M, Dennison DK. A new method for isolation of salivary neutrophils and determination of their functional activity. J Dent Res 1989; 68: 1256-1261.
9. Akpek G, Knight RD, Wright DG. Use of oral mucosal neutrophil counts to detect the onset and resolution of profound neutropenia following high-dose myelosuppressive chemotherapy. Am J Hematol 2003; 72: 13-19.
10. Sonis ST, Eilers JP, Epstein JB et al. Validation of a new scoring system for the assessment of clinical trial research of oral mucositis induced by radiation or chemotherapy. Mucositis Study Group. Cancer 1999; 85: 2103-2113.
11. Bellm LA, Epstein JB, Rose-Ped A et al. Patient reports of complications of bone marrow transplantation. Support Care Cancer 2000; 8: 33-39.