Protein kinase D3 activation and phosphorylation by signaling through Gαq

Biochemical and Biophysical Research Communications

Volumn 335, Issue 2, 2005, Pages 270-276

  Yuan, Jingzhen ^a   Rey, Osvaldo ^a   Rozengurt, Enrique ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bombesin; Diacylglycerol; G protein coupled receptor; G proteins; Neuropeptide; Phorbol esters; PKC

Indexed keywords

ALUMINUM FLUORIDE; BOMBESIN RECEPTOR; DIACYLGLYCEROL; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA Q SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; NEUROPEPTIDE; PHORBOL ESTER DERIVATIVE; PROTEIN KINASE C; PROTEIN KINASE D; PROTEIN KINASE D 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL NUCLEUS; CELL STRAIN COS7; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; WILD TYPE;

ALUMINUM COMPOUNDS; ANIMALS; BLOTTING, WESTERN; CELL MEMBRANE; CELL NUCLEUS; CLONING, MOLECULAR; COS CELLS; CYTOSOL; DNA, COMPLEMENTARY; ENZYME ACTIVATION; ENZYME INHIBITORS; FLUORIDES; GENES, DOMINANT; GREEN FLUORESCENT PROTEINS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; IMMUNOPRECIPITATION; MICE; PHOSPHORYLATION; PROTEIN KINASE C; RECEPTORS, BOMBESIN; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 23744501055     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.06.209     Document Type: Article

References (42)

1. F.J. Johannes, J. Prestle, S. Eis, P. Oberhagemann, and K. Pfizenmaier PKCu is a novel, atypical member of the protein kinase C family J. Biol. Chem. 269 1994 6140 6148
2. A.M. Valverde, J. Sinnett-Smith, J. Van Lint, and E. Rozengurt Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain Proc. Natl. Acad. Sci. USA 91 1994 8572 8576
3. S. Sturany, J. Van Lint, F. Mueller, M. Wilda, H. Hameister, M. Hoecker, A. Brey, U. Gern, J. Vandenheede, T. Gress, G. Adler, and T. Seufferlein Molecular cloning and characterization of the human protein kinase D2: a novel member of the protein kinase D family of serine threonine kinases J. Biol. Chem. 276 2001 3310 3318
4. A. Hayashi, N. Seki, A. Hattori, S. Kozuma, T. Saito, and PKCnu, a new member of the protein kinase C family, composes a fourth subfamily with PKCmu Biochim. Biophys. Acta 1450 1999 99 106
5. O. Rey, J. Yuan, S.H. Young, and E. Rozengurt Protein kinase C nu/protein kinase D3 nuclear localization, catalytic activation, and intracellular redistribution in response to G protein-coupled receptor agonists J. Biol. Chem. 278 2003 23773 23785
6. S.K. Hanks Genomic analysis of the eukaryotic protein kinase superfamily: a perspective Genome Biol. 4 2003 111
7. E. Rozengurt, O. Rey, and R.T. Waldron Protein kinase D signaling J. Biol. Chem. 280 2005 13205 13208
8. J.L. Zugaza, R.T. Waldron, J. Sinnett-Smith, and E. Rozengurt Bombesin, vasopressin, endothelin, bradykinin, and platelet-derived growth factor rapidly activate protein kinase D through a protein kinase C-dependent signal transduction pathway J. Biol. Chem. 272 1997 23952 23960
9. J.L. Zugaza, J. Sinnett-Smith, J. Van Lint, and E. Rozengurt Protein kinase D (PKD) activation in intact cells through a protein kinase C-dependent signal transduction pathway EMBO J. 15 1996 6220 6230
10. R.T. Waldron, and E. Rozengurt Oxidative stress induces protein kinase D activation in intact cells-involvement of Src and dependence on protein kinase C J. Biol. Chem. 275 2000 17114 17121
11. S.A. Matthews, E. Rozengurt, and D. Cantrell Protein kinase D. A selective target for antigen receptors and a downstream target for protein kinase C in lymphocytes J. Exp. Med. 191 2000 2075 2082
12. T. Chiu, and E. Rozengurt PKD in intestinal epithelial cells: rapid activation by phorbol esters, LPA, and angiotensin through PKC Am. J. Physiol. Cell Physiol. 280 2001 C929 C942
13. T. Chiu, S.S. Wu, C. Santiskulvong, P. Tangkijvanich, H.F. Yee Jr., and E. Rozengurt Vasopressin-mediated mitogenic signaling in intestinal epithelial cells Am. J. Physiol. Cell Physiol. 282 2002 C434 C450
14. J. Yuan, L.W. Slice, J. Gu, and E. Rozengurt Cooperation of Gq, Gi, and G12/13 in protein kinase D activation and phosphorylation induced by lysophosphatidic acid J. Biol. Chem. 278 2003 4882 4891
15. R.T. Waldron, O. Rey, E. Zhukova, and E. Rozengurt Oxidative stress induces protein kinase C-mediated activation loop phosphorylation and nuclear redistribution of protein kinase D J. Biol. Chem. 279 2004 27482 27493
16. T. Iglesias, R.T. Waldron, and E. Rozengurt Identification of in vivo phosphorylation sites required for protein kinase D activation J. Biol. Chem. 273 1998 27662 27667
17. R.T. Waldron, O. Rey, T. Iglesias, T. Tugal, D. Cantrell, and E. Rozengurt Activation loop Ser744 and Ser748 in protein kinase D are transphosphorylated in vivo J. Biol. Chem. 276 2001 32606 32615
18. R.T. Waldron, and E. Rozengurt Protein kinase C phosphorylates protein kinase D activation loop Ser744 and Ser748 and releases autoinhibition by the pleckstrin homology domain J. Biol. Chem. 278 2003 154 163
19. O. Rey, J.R. Reeve Jr., E. Zhukova, J. Sinnett-Smith, and E. Rozengurt G protein-coupled receptor-mediated phosphorylation of the activation loop of protein kinase D: dependence on plasma membrane translocation and protein kinase Cepsilon J. Biol. Chem. 279 2004 34361 34372
20. O. Rey, S.H. Young, D. Cantrell, and E. Rozengurt Rapid protein kinase D translocation in response to G protein-coupled receptor activation. Dependence on protein kinase C J. Biol. Chem. 276 2001 32616 32626
21. E. Zhukova, J. Sinnett-Smith, and E. Rozengurt Protein kinase D potentiates DNA synthesis and cell proliferation induced by bombesin, vasopressin, or phorbol esters in Swiss 3T3 cells J. Biol. Chem. 276 2001 40298 40305
22. J. Sinnett-Smith, E. Zhukova, N. Hsieh, X. Jiang, and E. Rozengurt Protein kinase D potentiates DNA synthesis induced by Gq-coupled receptors by increasing the duration of ERK signaling in swiss 3T3 cells J. Biol. Chem. 279 2004 16883 16893
23. M. Liljedahl, Y. Maeda, A. Colanzi, I. Ayala, J. Van Lint, and V. Malhotra Protein kinase D regulates the fission of cell surface destined transport carriers from the trans-Golgi network Cell 104 2001 409 420
24. C. Hurd, and E. Rozengurt Protein kinase D is sufficient to suppress EGF-induced c-Jun Ser 63 phosphorylation Biochem. Biophys. Res. Commun. 282 2001 404 408
25. C. Hurd, R.T. Waldron, and E. Rozengurt Protein kinase D complexes with C-Jun N-terminal kinase via activation loop phosphorylation and phosphorylates the C-Jun N-terminus Oncogene 21 2002 2154 2160
26. C.P. Bagowski, M. Stein-Gerlach, A. Choidas, and A. Ullrich Cell-type specific phosphorylation of threonines T654 and T669 by PKD defines the signal capacity of the EGF receptor EMBO J. 18 1999 5567 5576
27. P. Storz, and A. Toker Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway EMBO J. 22 2003 109 120
28. N.L. Prigozhina, and C.M. Waterman-Storer Protein kinase D-mediated anterograde membrane trafficking is required for fibroblast motility Curr. Biol. 14 2004 88 98
29. S. Offermanns, and M.I. Simon Organization of transmembrane signalling by heterotrimeric G proteins Cancer Surv. 27 1996 177 198
30. P.B. Wedegaertner, D.H. Chu, P.T. Wilson, M.J. Levis, and H.R. Bourne Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha J. Biol. Chem. 268 1993 25001 25008
31. J. Yuan, L.W. Slice, and E. Rozengurt Activation of protein kinase D by signaling through Rho and the alpha subunit of the heterotrimeric G protein G13 J. Biol. Chem. 276 2001 38619 38627
32. L.K. Needham, and E. Rozengurt G-alpha-12 and G-alpha-13 stimulate Rho-dependent tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130 Crk-associated substrate J. Biol. Chem. 273 1998 14626 14632
33. D.Q. Wu, C.H. Lee, S.G. Rhee, and M.I. Simon Activation of phospholipase C by the alpha subunits of the Gq and G11 proteins in transfected Cos-7 cells J. Biol. Chem. 267 1992 1811 1817
34. D. Toullec, P. Pianetti, H. Coste, P. Bellevergue, T. Grandperret, M. Ajakane, V. Baudet, P. Boissin, E. Boursier, F. Loriolle, L. Duhamel, D. Charon, and J. Kirilovsky The bisindolylmaleimide Gf-109203x is a potent and selective inhibitor of protein kinase-C J. Biol. Chem. 266 1991 15771 15781
35. E.J. Yeo, and J.H. Exton Stimulation of phospholipase D by epidermal growth factor requires protein kinase C activation in Swiss 3T3 cells J. Biol. Chem. 270 1995 3980 3988
36. H.R. Bourne How receptors talk to trimeric G proteins Curr. Opin. Cell Biol. 9 1997 134 142
37. S.A. Akhter, L.M. Luttrell, H.A. Rockman, G. Iaccarino, R.J. Lefkowitz, and W.J. Koch Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy Science 280 1998 574 577
38. A. Gilchrist, M. Bèunemann, A. Li, M.M. Hosey, and H.E. Hamm A dominant-negative strategy for studying roles of G proteins in vivo J. Biol. Chem. 274 1999 6610 6616
39. A. Gilchrist, M.R. Mazzoni, B. Dineen, A. Dice, J. Linden, W.R. Proctor, C.R. Lupica, T.V. Dunwiddie, and H.E. Hamm Antagonists of the receptor-G protein interface block Gi-coupled signal transduction J. Biol. Chem. 273 1998 14912 14919
40. V. Radhika, and N. Dhanasekaran Transforming G proteins Oncogene 20 2001 1607 1614
41. S.R. Neves, P.T. Ram, and R. Iyengar G protein pathways Science 296 2002 1636 1639
42. G.W. Dorn II, and T. Force Protein kinase cascades in the regulation of cardiac hypertrophy J. Clin. Invest. 115 2005 527 537