Expression of early placenta insulin-like growth factor in breast cancer cells provides an autocrine loop that predominantly enhances invasiveness and motility

Endocrine-Related Cancer

Volumn 12, Issue 4, 2005, Pages 823-837

  Brandt, B ^a   Kemming, D ^a   Packeisen, J ^b   Simon, R ^e   Helms, M ^a   Feldmann, U ^b   Matuschek, A ^a   Kersting, C ^b   Hinrichs, B ^c   Bidart, J M ^c   Bellet, D ^d   Bartkowiak, K ^a   Dankbar, N ^a   Dittmar, T ^f   Sauter, G ^e   Boecker, W ^b   Buerger, H ^b  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c UNIVERSITY OF COLOGNE   (Germany)

^d INSTITUT GUSTAVE ROUSSY   (France)

^e UNIVERSITY OF BASEL   (Switzerland)

^f UNIVERSITY OF WITTEN HERDECKE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EARLY PLACENTA INSULIN GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOLIPASE C GAMMA1; PROTEIN; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ARTICLE; AUTOCRINE EFFECT; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CANCER INVASION; CANCER SURVIVAL; CELL INVASION; CELL MOTILITY; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LAMELLIPODIUM; PAGET NIPPLE DISEASE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TISSUE MICROARRAY;

AUTOCRINE COMMUNICATION; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CULTURE MEDIA, CONDITIONED; ENDOTHELIAL CELLS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; NEOPLASM INVASIVENESS; PAGET'S DISEASE, MAMMARY; PROGNOSIS; PROTEIN ARRAY ANALYSIS; RECEPTOR, ERBB-2; RNA, SMALL INTERFERING;

EID: 23744497372     PISSN: 13510088     EISSN: None     Source Type: Journal    
DOI: 10.1677/erc.1.00975     Document Type: Article

References (19)

1. Balana ME, Labriola L, Salatino M, Movsichoff F, Peters G, Charreau EH & Elizade PV 2001 Activation of erbB-2 via hierarchical interaction between erbB-2 and type I insulin-like growth factor receptor in mammary tumor cells. Oncogene 20 3434-3447.
2. Bellet D, Lavaissiere L, Mock P, Laurent A, Sabourin JC, Bedossa P, Le Bouteiller P, Frydman R, Troalen F & Bidart JM 1997 Identification of pro-EPIL and EPIL peptides translated from insulin-like 4 (INSL4) mRNA in human placenta. Journal of Clinical Endocrinology and Metabolism 82 3169-3172.
3. Brandt B, Roetger A, Dittmar T, Nikolai G, Merschjann A, Nofer J-R, Assmann G & Zaenker KS 1999 c-erbB-2/EGFR as dominant heterodimerization partners determine a motogenic phenotype in human breast cancer cells. FASEB Journal 13 1939-1949.
4. Brandt B, Roetger A, Bidart J-M, Packeisen J, Schier K, Mikesch J-H, Kemming D, Boecker W, Yu D & Buerger H 2002 Early placenta insulin like growth factor (pro-EPIL) is overexpressed and secreted by c-erbB-2 positive cells with high invasion potential. Cancer Research 62 1020-1024.
5. Chassin D, Laurent A, Janneau JL, Berger R & Bellet D 1995 Cloning of a new member of the insulin gene superfamily (INSL4) expressed in human placenta. Genomics 29 465-470.
6. De Potter CR & Schelfhout AM 1995 The neu-protein and breast cancer. Virchows Archiv 426 107-115.
7. Dittmar T, Husemann A, Schewe Y, Nofer J-R, Niggemann B, Zänker KS & Brandt BH 2002 Induction of cancer cell migration by epidermal growth factor is initiated by specific phosphorylation of tyrosine 1248 of c-erbB-2 receptor via EGFR. FASEB Journal 16 1823-1825.
8. Gilmore AP, Valentijn AJ, Wang P, Ranger AM, Bundred N, O'Hare MJ, Wakeling A, Korsmeyer SJ & Streuli CH 2002 Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor. Journal of Biological Chemistry 277 27643-27650.
9. Graus-Porta D, Beerli RR, Daly JM & Hynes NE 1997 ErbB-2, the preferred heterodimerization partner of all erbB receptors, is a mediator of lateral signaling. EMBO Journal 16 1647-1655.
10. Guidi A, Laricchia-Robbio L, Gianfaldoni D, Revoltella R & Del Bono G 2001 Comparison of a conventional immunoassay (ELISA) with a surface plasmon resonance-based biosensor for IGF-1 detection in cows' milk. Biosensors and Bioelectronics 16 971-977.
11. Hombach-Klonisch S, Buchmann J, Sarun S, Fischer B & Klonisch T 2000 Relaxin-like factor (RLF) is differentially expressed in the normal and neoplastic human mammary gland. Cancer 89 2161-2168.
12. Irvine RF & Schell MJ 2001 Back in the water: the return of the inositol phosphates. Nature Reviews in Molecular and Cellular Biology 2 327-338.
13. Katterle Y, Brandt BH, Dowdy SF, Niggemann B, Zänker KS & Dittmar T 2004 Effective inhibition of EGF induced cell migration of EGFR/c-erbB-2 positive breast cancer cells using a recombinant PLC-γ1-(SH2)2-TAT protein. British Journal of Cancer 90 230-235.
14. Mann CJ, Stephens SK & Burke JF 2004 Production of protein microarrays. In Protein Microarray Technology. Ed. D Kambhampati. Wiley-VCH.
15. Mock P, Frydman R, Bellet D, Diawara DA, Lavaissiere L, Troalen F & Bidart JM 1999 Pro-EPIL forms are present in amniotic fluid and maternal serum during normal pregnancy. Journal of Clinical Endocrinology and Metabolism 84 2253-2256.
16. Rasmussen AA & Cullen KJ 1998 Paracrine/autocrine regulation of breast cancer by insulin-like growth factors. Breast Cancer Research and Treatment 47 219-233.
17. Roetger A, Merschjann A, Dittmar T, Jackisch C, Barnekow A & Brandt B 1998 Selection of potentially metastatic subpopulations expressing c-erbB-2 from breast cancer tissue by use of an extravasation model. American Journal of Pathology 153 697-1860.
18. Roundabush FL, Pierce KL, Maudsley S, Khan DK & Luttrell LM 2000 Transactivation of the EGF receptor mediates IGF-1-stimulated Shc phosphorylation and erk1/2 activation in COS-7 cells. Journal of Biological Chemistry 275 22583-22589.
19. Schelfhout VR, Coene ED, Delaey B, Thys S, Page DL & De Potter CR 2000 Pathogenesis of Paget's disease: epidermal heregulin-alpha, motility factor, and the HER receptor family. Journal of the National Cancer Institute 92 622-628.