Association of human follitropin (FSH) receptor with splicing variant of human lutropin/choriogonadotropin receptor negatively controls the expression of human FSH receptor

Molecular Endocrinology

Volumn 19, Issue 8, 2005, Pages 2099-2111

  Yamashita, Soichi ^a   Nakamura, Kazuto ^a,b   Omori, Yuki ^a   Tsunekawa, Katsuhiko ^a   Murakami, Masami ^a   Minegishi, Takashi ^a,b  

^a GUNMA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN RECEPTOR; CYCLIC AMP; DETERGENT; FOLLITROPIN RECEPTOR; GLYCOSIDASE; GONADOTROPIN RECEPTOR; LUTEINIZING HORMONE RECEPTOR; THYROTROPIN RECEPTOR;

ARTICLE; BIOTINYLATION; CELL MEMBRANE; CELL SURFACE; COMPARATIVE STUDY; CONTROLLED STUDY; CORPUS LUTEUM; ENDOPLASMIC RETICULUM; EXON; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; LYSOSOME; MENSTRUAL CYCLE; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ALTERNATIVE SPLICING; BIOTINYLATION; BLOTTING, WESTERN; CELL LINE; CYCLIC AMP; DETERGENTS; DNA, COMPLEMENTARY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOPLASMIC RETICULUM; EXONS; FEMALE; GENE EXPRESSION REGULATION; GENETIC VECTORS; GLYCOSIDE HYDROLASES; GLYCOSYLATION; HUMANS; IMMUNOPRECIPITATION; LYSOSOMES; MENSTRUAL CYCLE; MUTATION; OVARY; PLASMIDS; PROTEIN BINDING; PROTEIN FOLDING; RECEPTORS, FSH; RECEPTORS, LH; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUBCELLULAR FRACTIONS; TRANSFECTION;

EID: 23744480235     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2005-0049     Document Type: Article

References (35)

1. Segaloff DL, Ascoli M 1993 The lutropin/choriogonadotropin receptor . . . 4 years later. Endocr Rev 14:324-347
2. Dufau ML 1998 The luteinizing hormone receptor. Annu Rev Physiol 60:461-496
3. Minegishi T, Nakamura K, Takakura Y, Ibuki Y, Igarashi M, Minegish T 1991 Cloning and sequencing of human FSH receptor cDNA. Biochem Biophys Res Commun 175:1125-1130
4. Minegishi T, Nakamura K, Takakura Y, Miyamoto K, Hasegawa Y, Ibuki Y 1990 Cloning and sequencing of human LH/hCG receptor cDNA. Biochem Biophys Res Commun 172:1049-1054
5. Laue LL, Wu SM, Kudo M, Bourdony CJ, Cutler GBJ, Hsueh AJ, Chan WY 1996 Compound heterozygous mutations of the luteinizing hormone receptor gene in Leydig cell hypoplasia. Mol Endocrinol 10:987-997
6. Gromoll J, Eiholzer U, Nieschlag E, Simoni M 2000 Male hypogonadism caused by homozygous deletion of exon 10 of the luteinizing hormone receptor: differential action of the luteinizing hormone (LH) and human chorionic gonadotropin (hCG). J Clin Endocrinol Metab 85:2281-2286
7. Minegishi T, Tano M, Abe Y, Nakamura K, Ibuki Y, Miyamoto K 1997 Expression of luteinizing hormone/human chorionic gonadotropin (LH/HCG) receptor mRNA in the human ovary. Mol Hum Reprod 3:101-107
8. Bai M 2004 Dimerization of G-protein-coupled receptors: roles in signal transduction. Cell Signal 16:175-186
9. Fan QR, Hendrickson WA 2005 Structure of human follicle-stimulating hormone in complex with its receptor. Nature 433:203-204
10. Jordan BA, Devi LA 1999 G-protein-coupled receptor heterodimerization modulates receptor function. Nature 399:697-700
11. Lavoie C, Mercier JF, Salahpour A, Umapathy D, Breit A, Villeneuve LR, Zhu WZ, Xiao RP, Lakatta EG, Bouvier M, Hebert TE 2002 β 1/β 2-Adrenergic receptor heterodimerization regulates β 2-adrenergic receptor internalization and ERK signaling efficacy. J Biol Chem 277:35402-35410
12. Rocheville M, Lange DC, Kumar U, Sasi R, Patel RC, Patel YC 2000 Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers. J Biol Chem 275:7862-7869
13. Oktay K, Briggs D, Gosden RG 1997 Ontogeny of follicle-stimulating hormone receptor gene expression in isolated human ovarian follicles. J Clin Endocrinol Metab 82:3748-3751
14. Kremer H, Kraaij R, Toledo SP, Post M, Fridman JB, Hayashida CY, van Reen M, Milgrom E, Ropers HH, Mariman E, Themmen AP, Brunner HG 1995 Male pseudohermaphroditism due to a homozygous missense mutation of the luteinizing hormone receptor gene. Nat Genet 9:160-164
15. Sergio PA, Toledo HG, Brunner HG, Kraaij R, Post M, Dahia PLM, Hayashida CY, Kremer H, Themmen APN 1996 An inactivating mutation of the luteinizing hormone receptor causes amenorrhea in a 46, XX female. J Clin Endocrinol Metab 81:3850-3854
16. Latronico AC, Anasti J, Arnhold IJ, Rapaport R, Mendonca BB, Bloise W, Castro M, Tsigos C, Chrousos GP 1996 Brief report: testicular and ovarian resistance to luteinizing hormone caused by inactivating mutations of the luteinizing hormone-receptor gene. N Engl J Med 334:507-512
17. Jordan BA, Trapaidze N, Gomes I, Nivarthi R, Devi LA 2001 Oligomerization of opioid receptors with β2-adrenergic receptors: a role in trafficking and mitogen-activated protein kinase activation. Proc Natl Acad Sci USA 98:343-348
18. Pfeiffer M, Koch T, Schroder H, Klutzny M, Kirscht S, Kreienkamp H-J, Hollt V, Schulz S 2001 Homo-and heterodimerization of somatostatin receptor subtypes. J Biol Chem 276:14027-14036
19. Tao YX, Johnson NB, Segaloff DL 2004 Constitutive and agonist-dependent self-association of the cell surface human lutropin receptor. J Biol Chem 279:5904-5914
20. Nakamura K, Yamashita S, Omori Y, Minegishi T 2004 A splice variant of the human luteinizing hormone (LH) receptor modulates the expression of wild-type human LH receptor. Mol Endocrinol 18:1461-1470
21. Benkirane M, Jin DY, Chun RF, Koup RA, Jeang KT 1997 Mechnism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5Δ32. J Biol Chem 273:30603-30606
22. Ascoli M, Fanelli F, Segaloff DL 2002 The lutropin/choriogonadotropin receptor, a 2002 perspective. Endocr Rev 23:141-174
23. Themmen APN, Huhtaniemi IT 2000 Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function. Endocr Rev 21:551-583
24. Rozell TG, Davis DP, Chai Y, Segaloff DL 1998 Association of gonadotropin receptor precursors with the protein folding chaperone calnexin. Endocrinology 139:1588-1593
25. Minegish T, Tano M, Igarashi M, Rokukawa S, Abe Y, Ibuki Y, Miyamoto K 1997 Expression of follicle-stimulating hormone receptor in human ovary. Eur J Clin Invest 27:469-474
26. Zhang FP, Kero J, Huhataniemi I 1998 The unique exon 10 of the human luteinizing hormone receptor is necessary for expression of the receptor protein at the plasma membrane in the human luteinizing hormone receptor, but deleterious when inserted in the human follicle-stimulating hormone receptor. Mol Cell Endocrinol 142:165-174
27. Thomas D, Rozell TG, Liu X, Segaloff DL 1996 Mutational analysis of the extracellular domain of the full-length lutropin/choriogonadotropin receptor suggest leucinerich repeats 1-6 are involved in hormone binding. Mol Endocrinol 10:760-768
28. Fabritz J, Ryan S, Ascoli M 1998 Transfected cells express mostly the intracellular precursor of the lutropin/choriogonadotropin receptor but this precursor binds choriogonadotropin with high affinity. Biochemistry 37:664-672
29. Zeng H, Phang T, Song Y, Ji I, Ji T 2001 The role of the hinge region of the luteinizing hormone receptor in hormone interaction and signal generation. J Biol Chem 276:3451-3458
30. Nakabayashi K, Kudo M, Kobilka BK, Hsueh AJW 2000 Activation of the luteinizing hormone receptor following substitution of Ser-277 with selective hydrophobic residues in the ectodomain hinge region. J Biol Chem 275:30264-30271
31. Zhang R, Buczko E, Dufau ML 1996 Requirement of cysteine residues in exons 1-6 of the extracellular domain of the luteinizing hormone receptor for gonadotropin binding. J Biol Chem 271:5755-5760
32. Chen C, Okayama H 1987 High-efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol 7:2745-2752
33. Quintana J, Hipkin RW, Ascoli M 1993 A polyclonal antibody to a synthetic peptide derived from the rat FSH receptor reveals the recombinant receptor as a 74 kDa protein. Endocrinology 133:2096-2104
34. Nakamura K, Ascoli M 1999 A dileucine-based motif in the C-terminal tail of the lutropin/choriogonadotropin receptor inhibits endocytosis of the agonist-receptor complex. Mol Pharmacol 56:728-736
35. Nakamura K, Liu X, Ascoli M 1999 The rate of internalization of the gonadotropin receptors is greatly affected by the origin of the extracellular domain. J Biol Chem 274:25426-25432