Platelets express steroidogenic 17β-hydroxysteroid dehydrogenases. Distinct profiles predict the essential thrombocythemic phenotype

Thrombosis and Haemostasis

Volumn 94, Issue 2, 2005, Pages 412-421

  Gnatenko, Dmitri V ^a   Cupit, Lisa D ^a   Huang, Emily C ^a   Dhundale, Anilkumar ^a   Perrotta, Peter L ^b   Bahou, Wadie F ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

Essential thrombocythemia; Hydroxysteroid dehydrogenases; Microarray; Platelets

Indexed keywords

ANDROGEN; TESTOSTERONE 17BETA DEHYDROGENASE;

ADULT; AGED; ANDROGEN SYNTHESIS; ARTICLE; BLEEDING DISORDER; CARDIOVASCULAR DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; DISEASE ASSOCIATION; DOWN REGULATION; ENZYME INDUCTION; ENZYME SPECIFICITY; FEMALE; GENE EXPRESSION; GENETIC CODE; HUMAN; HUMAN CELL; MALE; MOLECULAR BIOLOGY; MOUSE; MYELOPROLIFERATIVE DISORDER; NEUROLOGIC DISEASE; NONHUMAN; PHENOTYPE; PREDICTION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MICROARRAY; STATISTICAL ANALYSIS; STEROIDOGENESIS; SYMPTOMATOLOGY; TESTIS; THROMBOCYTE; THROMBOCYTE ANOMALY; THROMBOCYTE DISORDER; THROMBOCYTHEMIA; THROMBOSIS;

17-HYDROXYSTEROID DEHYDROGENASES; ADULT; AGED; ANIMALS; BLOOD PLATELETS; COMPUTATIONAL BIOLOGY; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MALE; MICE; MIDDLE AGED; PHENOTYPE; PHYLOGENY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TESTIS; THROMBOCYTOSIS; TIME FACTORS; UP-REGULATION;

EID: 23744465574     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH05-01-0037     Document Type: Article

References (34)

1. Gnatenko DV, Dunn JJ, McCorkle SR et al. Transcript profiling of human platelets using microarray and serial analysis of gene expression. Blood 2003; 101: 2285-93.
2. Nimer SD. Essential thrombocythemia: Another "heterogeneous disease" better understood? Blood 1999; 93: 415-16.
3. El-Kassar N, Hetet G, Briere J et al. Clonality analysis of hematopoiesis in essential thrombocythemia: Advantages of studying T lymphocytes and platelets. Blood 1997; 89: 128.
4. Kondo T, Okabe M, Sanada M et al. Familial essential thrombocythemia associated with one-base deletion in the 5′-untranslated region of the thrombopoietin gene. Blood 1998; 92: 1091.
5. Schafer AI. Thrombocytosis. N Engl J Med 2004; 350: 1211-9.
6. Bahou WF, Gnatenko DV. Platelet transcriptome: the application of microarray analysis to platelets. Semin Thromb Hemost 2004; 30: 473-84.
7. Iland HJ, Laszlo J, Case DC, Jr. et al. Differentiation between essential thrombocythemia and polycythemia vera with marked thrombocytosis. Am J Hematol 1987; 25: 191-201.
8. Murphy S, Peterson P, Iland H et al. Experience of the Polycythemia Vera Study Group with essential thrombocythemia: a final report on diagnostic criteria, survival, and leukemic transition by treatment. Semin Hematol 1997; 34: 29-39.
9. Mirza H, Yatsula V, Bahou WF. The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial cells. Molecular characterization and evidence for functional coupling to the thrombin receptor. J Clin Invest 1996; 97: 1705-14.
10. Heid CA, Stevens J, Livak KJ et al. Real time quantitative PCR. Genome Res 1996; 6: 986-94.
11. Schmidt VA, Nierman WC, Maglott DR et al. The human proteinase-activated receptor-3 (PAR-3) gene. Identification within a PAR gene cluster and characterization in vascular endothelial cells and platelets. J Biol Chem 1998; 273: 15061-8.
12. Tenedini E, Fagioli ME, Vianelli N et al. Gene expression profiling of normal and malignant CD34-derived megakaryocytic cells. Blood 2004; 104: 3126-35.
13. Bahou WF, Scudder L, Rubenstein D et al. A shear-restricted pathway of platelet procoagulant activity is regulated by IQGAP1. J Biol Chem 2004; 279: 22571-7.
14. Dhanasekaran SM, Barrette TR, Ghosh D et al. Delineation of prognostic biomarkers in prostate cancer. Nature 2001; 412: 822-6.
15. Mehta T, Tanik M, Allison DB. Towards sound epistemological foundations of statistical methods for high-dimensional biology. Nat Genet 2004; 36: 943-7.
16. Bahou WF. Protease-activated receptors. Curr Top Dev Biol 2003; 54: 343-69.
17. Lane WJ, Dias S, Hattori K et al. Stromal-derived factor 1-induced megakaryocyte migration and platelet production is dependent on matrix metalloproteinases. Blood 2000; 96: 4152-9.
18. Labrie F. Luu-The V, Labrie C et al. Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone. Endocr Rev 2003; 24: 152-82.
19. Velculescu V, Zhang L, Vogelstein B et al. Serial analysis of gene expression. Science 1995; 270: 484-7.
20. Strausberg RL, Buetow KH, Emmert-Buck MR et al. The cancer genome anatomy project: building an annotated gene index. Trends Genet 2000; 16: 103-6.
21. Geissler WM, Davis DL, Wu L et al. Male pseudohermaphroditism caused by mutations of testicular 17 beta-hydroxysteroid dehydrogenase 3. Nat Genet 1994; 7: 34-9.
22. Khetawat G, Faraday N, Nealen ML et al. Human megakaryocytes and platelets contain the estrogen receptor beta and androgen receptor (AR): testosterone regulates AR expression. Blood 2000; 95: 2289-96.
23. Nagata Y, Yoshikawa J, Hashimoto A et al. Proplatelet formation of megakaryocytes is triggered by autocrine-synthesized estradiol. Genes Dev 2003; 17: 2864-9.
24. Mindnich R, Moller G, Adamski J. The role of 17 beta-hydroxysteroid dehydrogenases. Mol Cell Endocrinol 2004; 218: 7-20.
25. Mount S. A catologue of splice junction sequences. Nucl Acid Res 1982; 10: 459-72.
26. Mindnich R, Deluca D, Adamski J. Identification and characterization of 17 beta-hydroxysteroid dehydrogenases in the zebrafish, Danio rerio. Mol Cell Endocrinol 2004; 215: 19-30.
27. Wattel E, Cambier N, Caulier MT et al. Androgen therapy in myelodysplastic, syndromes with thrombocytopenia: a report on 20 cases. Br J Haematol 1994; 87: 205-8.
28. Sullivan PS, Jackson CW, McDonald TP. Castration decreases thrombocytopoiesis and testosterone restores platelet production in castrated BALB/c mice: evidence that testosterone acts on a bipotential hematopoietic precursor cell. J Lab Clin Med 1995; 125: 326-33.
29. Johnson M, Ramey E, Ramwell PW. Sex and age differences in human platelet aggregation. Nature 1975; 253: 355-7.
30. Jones SB, Bylund DB, Rieser CA et al. alpha 2-Adrenergic receptor binding in human platelets: alterations during the menstrual cycle. Clin Pharmacol Ther 1983; 34: 90-6.
31. Pilo R, Aharony D, Raz A. Testosterone potentiation of ionophore and ADP induced platelet aggregation: relationship to arachidonic acid metabolism. Thromb Haemost 1981; 46: 538-42.
32. Castellsague J, Perez Gutthann S, Garcia Rodriguez LA. Recent epidemiological studies of the association between hormone replacement therapy and venous thromboembolism. A review. Drug Saf 1998; 18: 117-23.
33. Daly E, Vessey MP, Hawkins MM et al. Risk of venous thromboembolism in users of hormone replacement therapy. Lancet 1996; 348: 977-80.
34. Greenberg D, Miao CH, Ho WT et al. Liver-specific expression of the human factor VII gene. Proc Natl Acad Sci U S A 1995; 92: 12347-51.