Gelatinases [matrix metalloproteinase-2 (MMP-2) and MMP-9] induce carotid plaque instability but their systemic levels are not predictive of local events

Annals of Vascular Surgery

Volumn 19, Issue 4, 2005, Pages 529-533

  Tziakas, D N ^a   Lazarides, M K ^a,b   Tentes, I K ^a   Georgiadis, G S ^a   Eleftheriadou, E ^a   Chalikias, G K ^a   Kortsaris, A ^a   Hatseras, D I ^a  

^a DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

^b NONE   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

GELATINASE A; GELATINASE B;

ADULT; AGED; ARTICLE; ATHEROSCLEROTIC PLAQUE; CLINICAL ARTICLE; CONTROLLED STUDY; ENDARTERECTOMY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MALE; PREDICTION; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

EID: 23744443797     PISSN: 08905096     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10016-005-5018-6     Document Type: Article

References (17)

1. Loftus IM, Naylor AR, Goodall S, et al.Increased matrix metalloproteinase-9 activity in unstable carotid plaques. A potential role in acute plaque disruption. Stroke 2000;31:40-47.
2. Hower CD, Dassow MS, Kajdacsy-Balla A, et al.Metalloproteinase levels are decreased in symptomatic carotid plaques. J. Surg. Res. 2000;88:155-159.
3. North American Symptomatic Carotid Endarterectomy Trial Collaborators. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N. Engl. J. Med. 1991;325:445-453.
4. Bassiouny HS, Davis H, Massawa N, Gewertz BL, Glagov S, Zarins CK. Critical carotid stenoses: morphologic and chemical similarity between symptomatic and asymptomatic plaques. J. Vasc. Surg. 1989;9:202-212.
5. Stary HC. Natural history and histological classification of atherosclerotic lesions. Arterioscler. Thromb. Vasc. Biol. 2000;20:1177-1178.
6. Lewis KM, Rehm JP, Baxter BT. Molecular demolition: the role of matrix metalloproteinases in arterial disease. Adv. Vasc. Surg. 2000;8:197-213.
7. Loftus IM, Naylor AR, Bell PRF, Thompson MM. Matrix metalloproteinases and atherosclerotic instability. Br. J. Surg. 2002;89:680-694.
8. Davis MJ. Reactive oxygen species, metalloproteinases and plaque stability. Circulation 1998;97:2382-2383.
9. Tziakas DN, Chalikias GK, Hatzinikolaou HI, et al.Antiinflammatory cytokine profile in acute coronary syndromes: behavior of interleukin-10 in association with serum metalloproteinases and proinflammatory cytokines. Int. J. Cardiol. 2003;92:169-175.
10. Carr S, Farb A, Pearce WH, Virmani R, Yao JST. Atherosclerotic plaque rupture in symptomatic carotid artery stenosis. J. Vasc. Surg. 1996;23:755-766.
11. Kai H, Ikeda H, Yasukawa H, et al.Peripheral blood levels of MMP-2 and MMP-9 are elevated in patients with acute coronary syndromes. J. Am. Coll. Cardiol. 1998;32:368-372.
12. Loftus IM, Naylor AR, Bell PRF, Thompson MM. Plasma MMP-9 a marker of carotid plaque instability. Eur. J. Vasc. Endovasc. Surg. 2001;21:17-21.
13. Alvarez B, Ruiz C, Chacon P, Sabin-Alvarez J, Matas M. Serum values of metalloproteinase-2 and metalloproteinase-9 as related to unstable plaque and inflammatory cells in patients with greater than 70% carotid artery stenosis. J. Vasc. Surg. 2004;40:469-475.
14. Molloy KJ, Thompson MM, Schwalbe EC, Bell PRF, Naylor AR, Loftus IM. Elevation in plasma MMP-9 following carotid endarterectomy is associated with particulate cerebral embolisation. Eur. J. Vasc. Endovasc. Surg. 2004;27:409-413.
15. Montaner J, Alvarez-Sabin J, Molina C, et al. Matrix metalloproteinase expression after human cardioembolic stroke. Temporal profile and relation to neurological impairment. Stroke 2001;32:1759-1766.
16. Axisa B, Loftus IM, Naylor AR, et al.Prospective randomized double-blind trial investigating the effect of doxycycline on matrix metalloproteinase expression within atherosclerotic carotid plaques. Stroke 2003;33:2858-2865.
17. Crisby M, Nordin-Fredriksson G, Shah PK, Yano J, Zhu J, Nilsson J. Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases and cell death in human carotid plaques. Implications for plaque stabilization. Circulation 2001;103:926-933.