The effects of quinapril and atorvastatin on artery structure and function in adult spontaneously hypertensive rats

European Journal of Pharmacology

Volumn 518, Issue 2-3, 2005, Pages 145-151

  Yang, Lufang ^a   Gao, Yu Jing ^a   Lee, Robert M K W ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Apoptosis; Atorvastatin; Confocal microscopy; Hypertension; Morphometry; Quinapril; Vascular reactivity

Indexed keywords

ACETYLCHOLINE; ATORVASTATIN; NITROPRUSSIDE SODIUM; NORADRENALIN; QUINAPRIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTERY; ARTERY CONSTRICTION; ARTERY MEDIA; ARTICLE; BLOOD VOLUME; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG EFFECT; ELECTROSTIMULATION; HEART VENTRICLE HYPERTROPHY; HYPERTENSION; MALE; MEASUREMENT; MESENTERY; MORPHOMETRICS; NICK END LABELING; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; RAT; RAT STRAIN; SMOOTH MUSCLE FIBER; SYSTOLIC BLOOD PRESSURE;

ACETYLCHOLINE; ANIMALS; ANTIHYPERTENSIVE AGENTS; APOPTOSIS; ARTERIES; BLOOD PRESSURE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ENDOTHELIAL CELLS; HEPTANOIC ACIDS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERTENSION; IN SITU NICK-END LABELING; MALE; MESENTERIC ARTERIES; MICROSCOPY, CONFOCAL; NITROPRUSSIDE; NOREPINEPHRINE; PYRROLES; RATS; RATS, INBRED SHR; RATS, INBRED WKY; TETRAHYDROISOQUINOLINES; TIME FACTORS; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

EID: 23644461955     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.05.009     Document Type: Article

References (22)

1. M.R. Bennett Apoptosis of vascular smooth muscle cells in vascular remodelling and atherosclerotic plaque rupture Cardiovasc. Res. 41 1999 361 368
2. L. Bravo, M.D. Herrera, E. Marhuenda, and C. Perez-Guerrero Cardiovascular effects of lovastatin in normotensive and spontaneously hypertensive rats Gen. Pharmacol. 30 1998 331 336
3. C.G. Brilla, L. Matsubara, and K.T. Weber Advanced hypertensive heart disease in spontaneously hypertensive rats. Lisinopril-mediated regression of myocardial fibrosis Hypertension 28 1996 269 275
4. W.H. Cline Jr. Enhanced in vivo responsiveness of presynaptic angiotensin II receptor-mediated facilitation of vascular adrenergic neurotransmission in spontaneously hypertensive rats J. Pharmacol. Exp. Ther. 232 1985 661 669
5. D. DeBlois, B.S. Tea, T.V. Dam, J. Tremblay, and P. Hamet Smooth muscle apoptosis during vascular regression in spontaneously hypertensive rats Hypertension 29 1997 340 349
6. J.G. Dickhout, and R.M.K.W. Lee Structural and functional analysis of small arteries from young spontaneously hypertensive rats Hypertension 29 1997 781 789
7. J.G. Dickhout, and R.M.K.W. Lee Apoptosis in the muscular arteries from young spontaneously hypertensive rats J. Hypertens. 17 1999 1413 1419
8. J.G. Dickhout, and R.M.K.W. Lee Increased medial smooth muscle cell length is responsible for vascular hypertrophy in young hypertensive rats Am. J. Physiol Heart Circ. Physiol. 279 2000 H2085 H2094
9. J. Diez, A. Panizo, M. Hernández, M.F. Galindo, E. Cenarruzabeitia, and F.J.P. Mindán Quinapril inhibits c-myc expression and normalizes smooth muscle cell proliferation in spontaneously hypertensive rats Am. J. Hypertens. 10 1997 1147 1152
10. S.A. Dukacz, M.G. Feng, L.F. Yang, R.M.K.W. Lee, and R.L. Kline Abnormal renal medullary response to angiotensin II in SHR is corrected by long-term enalapril treatment Am. J. Physiol., Regul. Integr. Comp. Physiol. 280 2001 R1076 R1084
11. R.M.K.W. Lee, R.E. Garfield, J.B. Forrest, and E.E. Daniel Morphometric study of structural changes in the mesenteric blood vessels of spontaneously hypertensive rats Blood Vessels 20 1983 57 71
12. R.M.K.W. Lee, K.H. Berecek, J. Tsoporis, R. McKenzie, and C.R. Triggle Prevention of hypertension and vascular changes by captopril treatment Hypertension 17 1991 141 150
13. C. Lemne, A. Hamsten, F. Karpe, P. Nilsson-Ehle, and U. de Faire Dyslipoproteinemic changes in borderline hypertension Hypertension 24 1994 605 610
14. N. Li, M. Sawamura, Y. Nara, K. Ikeda, and Y. Yamori Pravastatin affects blood pressure and vascular reactivity Heart and Vessels 11 1996 64 68
15. Z.H. Lin, L.D. Xie, K.G. Wu, H.J. Wang, and C.S. Xu Effects of fluvastatin on structure and function of resistant vessels in spontaneously hypertensive rats Zhongguo Yao Li XueBao. 20 1999 855 860
16. M.J. Lundie, P. Friberg, R.L. Kline, and M.A. Adams Long-term inhibition of the renin-angiotensin system in genetic hypertension: analysis of the impact on blood pressure and cardiovascular structural changes J. Hypertens. 15 1997 339 348
17. T. Ohwada, T. Ishibashi, H. Yaoita, J. Shindo, H. Noji, H. Ohkawara, K. Sugimoto, T. Sakamoto, K. Maehara, and Y. Maruyama Different contribution of apoptosis to the antiproliferative effects of l-arginine, enalapril and losartan on neointimal growth inhibition after balloon arterial injury Circ. J. 66 2002 965 971
18. T.K. Peters, J. Jewitt-Harris, M. Mehra, and E.N. Muratti Safety and tolerability of fluvastatin with concomitant use of antihypertensive agents. An analysis of a clinical trial database Am. J. Hypertens. 6 Pt 2 1993 346S 352S
19. M.J. Pollman, T. Yamada, M. Horiuchi, and G.H. Gibbons Vasoactive substances regulate vascular smooth muscle cell apoptosis-countervailing influences of nitric oxide and angiotensin II Circ. Res. 79 1996 748 756
20. J.S. Smeda Cerebral vascular changes associated with hemorrhagic stroke in hypertension Can. J. Physiol. Pharm. 70 1992 552 564
21. S. Wassmann, U. Laufs, A.T. Baumer, K. Muller, K. Ahlbory, W. Linz, G. Itter, R. Rosen, M. Bohm, and G. Nickenig HMG-CoA reductase inhibitors improve endothelial dysfunction in normocholesterolemic hypertension via reduced production of reactive oxygen species Hypertension 37 2001 1450 1457
22. L. Yang, Y.J. Gao, and R.M.K.W. Lee Quinapril effects on resistance artery structure and function in hypertension Naunyn Schmiedeberg's Arch. Pharmacol. 370 2004 444 451