A molecule's right to choose: How diabetogenic class II MHC products bind peptides

Journal of Clinical Investigation

Volumn 115, Issue 8, 2005, Pages 2077-2079

  Ploegh, Hidde L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DQ8 ANTIGEN; IA ANTIGEN; IA G7 ANTIGEN; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDE; UNCLASSIFIED DRUG;

ANTIGEN BINDING; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; AUTOIMMUNITY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; LIGAND BINDING; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE;

ANIMALS; AUTOANTIGENS; DIABETES MELLITUS, TYPE 1; HLA-DQ ANTIGENS; HUMANS; MICE; PEPTIDES; PROTEIN BINDING; T-LYMPHOCYTES;

EID: 23644461210     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI26018     Document Type: Review

References (4)

1. g7 molecules show common sequence specificity. J. Clin. Invest. 115:2268-2276. doi:10.1172/JCI25350.
2. Kast, W.M., et al. 1991. Protection against lethal Sendai virus infection by in vivo priming of virus-specific cytotoxic T lymphocytes with a free synthetic peptide. Proc. Natl Acad. Sci. U. S. A. 188:2283-2287.
3. Kent, S.C., et al. 2005. Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature. 435:224-228.
4. Antoniou, A.N., Blackwood, S.L., Mazzeo, D., and Watts, C. 2000. Control of antigen presentation by a single protease cleavage site. Immunity. 12:391-398.