Relaxin regulates collagen overproduction associated with experimental progressive renal fibrosis

Annals of the New York Academy of Sciences

Volumn 1041, Issue , 2005, Pages 182-184

  Samuel, Chrishan S ^a   Mookerjee, Ishanee ^a   Masterson, Rosemary ^b   Tregear, Geoffrey W ^a   Hewitson, Tim D ^b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Cortical fibroblasts; Gene knockout mice; Relaxin; Renal fibrosis; Unilateral ureteral obstruction

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN; COLLAGEN TYPE 1; COLLAGENASE 3; MESSENGER RNA; RECOMBINANT HUMAN RELAXIN 2; RELAXIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; COLLAGEN SYNTHESIS; CONFERENCE PAPER; DISEASE COURSE; EXPERIMENTAL MODEL; FEMALE; FIBROBLAST; KIDNEY DISEASE; KIDNEY FIBROSIS; KNOCKOUT MOUSE; MALE; NONHUMAN; URETER OBSTRUCTION;

EID: 23644461048     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1282.026     Document Type: Conference Paper

References (4)

1. EDDY, A.A. 2000. Molecular basis of renal fibrosis. Pediatr. Nephrol. 15: 290-301.
2. BECKER, G.J. & T.D. HEWITSON. 2000. The role of tubulointerstitial injury in chronic renal failure. Curr. Opin. Nephrol. Hypertens. 9: 133-138.
3. MASTERSON, R., T.D. HEWITSON, K. KELYNACK, et al. 2004. Relaxin down-regulates renal fibroblast function and promotes matrix remodelling in vitro. Nephrol. Dial. Transplant. 19: 544-552.
4. SAMUEL, C.S., C. ZHAO, C.P. BOND, et al. 2004. Relaxin-1-deficient mice develop and age-related progression of renal fibrosis. Kidney Int. 65: 2054-2064.