Increased aortic stiffness in the insulin-resistant Zucker fa/fa rat

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 289, Issue 2 58-2, 2005, Pages

  Sista, Akhilesh K ^a   O'Connell, Mary K ^b   Hinohara, Tomoya ^a   Oommen, Santosh S ^a   Fenster, Brett E ^a   Glassford, Alexander J ^a   Schwartz, Eric A ^a   Taylor, Charles A ^b   Reaven, Gerald M ^a   Tsao, Philip S ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Stanford University   (United States)

Author keywords

Arterial compliance; Extracellular matrix; Insulin resistance; Transforming growth factor ; Type 2 diabetes

Indexed keywords

COLLAGEN TYPE 4; FIBRONECTIN; INSULIN; MESSENGER RNA; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL TISSUE; AORTA MEDIA; ARTERY COMPLIANCE; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; EXTRACELLULAR MATRIX; IMMUNOHISTOCHEMISTRY; INSULIN RESISTANCE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; RIGIDITY; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA; ELASTICITY; EXTRACELLULAR MATRIX PROTEINS; INSULIN RESISTANCE; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; OBESITY; RATS; RATS, ZUCKER; SIGNAL TRANSDUCTION; TISSUE CULTURE TECHNIQUES; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 23644452788     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00134.2005     Document Type: Article

References (37)

1. Anderson PW, Zhang XY, Tian J, Correale JD, Xi XP, Yang D, Graf K, Law RE, and Hsueh WA. Insulin and angiotensin II are additive in stimulating TGF-β1 and matrix mRNAs in mesangial cells. Kidney Int 50: 745-753, 1996.
2. Aronson D. Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes. J Hypertens 21: 3-12, 2003.
3. Blancher J, Guerin AP, Pannier B, Marchais SJ, Safar ME, and London GM. Impact of aortic stiffness on survival in end-stage renal disease. Circulation 99: 2434-2439, 1999.
4. Blobe GC, Schiemann WP, and Lodish HF. Role of transforming growth factor-β in human disease. N Engl J Med 342: 1350-1358, 2000.
5. Bullo-Boneta M, Garcia-Lordaa P, Lopez-Soriano FJ, Argiles JM, and Salas-Salvado J. Tumour necrosis factor, a key role in obesity? FEBS Lett 451: 215-219, 1999.
6. Burton AC. Relation of structure to function of the tissues of the wall of blood vessels. Physiol Rev 34: 619-642, 1954.
7. Crawford SE, Stellmach V, Murphy-Ullrich JE, Ribeiro SM, Lawler J, Hynes RO, Boivin GP, and Bouck N. Thrombospondin-1 is a major activator of TGF-β1 in vivo. Cell 93: 1159-1170, 1998.
8. Crook ED, Simmons ST, Daniels M, and Singh LP. Regulation of glutamine:fructose-6-phosphate amidotransferase activity by high glucose and transforming growth factor-β in rat mesangial cells. J Investig Med 48: 427-434, 2000.
9. Cruickshank K, Riste L, Anderson SG, Wright JS, Dunn G, and Gosling RG. Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function? Circulation 106: 2085-2090, 2002.
10. Dingemans KP, Teeling P, Lagendijk JH, and Becker ÁE. Extracellular matrix of the human aortic media: an ultrastructural histochemical and immunohistochemical study of the adult aortic media. Anat Rec 258: 1-14, 2000.
11. Fung YC, Fronek K, and Patitucci P. Pseudoelasticity of arteries and the choice of its mathematical expression. Am J Physiol Heart Circ Physiol 237: H620-H631, 1979.
12. Gaballa MA, Jacob CT, Raya TE, Liu J, Simon B, and Goldman S. Large artery remodeling during aging: biaxial passive and active stiffness. Hypertension 32: 437-443, 1998.
13. Hansen TW, Jeppesen J, Rasmussen S, Ibsen H, and Torp-Pedersen C. Relation between insulin and aortic stiffness: a population-based study. J Hum Hypertens 18: 1-7, 2004.
14. Hosomi N, Noma T, Ohyama H, Takahashi T, and Kohno M. Vascular proliferation and transforming growth factor-β expression in pre- and early stage of diabetes mellitus in Otsuka Long-Evans Tokushima fatty rats. Atherosclerosis 162: 69-76, 2002.
15. Ihn H. Pathogenesis of fibrosis: role of TGF-β and CTGF. Curr Opin Rheumatol 14: 691-695, 2002.
16. Ito Y, Sarkar P, Mi Q, Wu N, Bringas P Jr, Liu Y, Reddy S, Maxson R, Dene C, and Chai Y. Overexpression of Smad 2 reveals its concerted action with Smad 4 in regulating TGF-β-mediated epidermal homeostasis. Dev Biol 236: 181-194, 2001.
17. Ito Y, Zhao J, Mogharei A, Shuler CF, Weinstein M, Deng C, and Chai Y. Antagonistic effects of Smad 2 versus Smad 7 are sensitive to their expression level during tooth development. J Biol Chem 276: 44163-44172, 2001.
18. Kaiura TL, Itoh H, Kubaska SM III, McCaffrey TA, Liu B, and Kent KC. The effect of growth factors, cytokines, and extracellular matrix proteins on fibronectin production in human vascular smooth muscle cells. J Vasc Surg 31: 577-584, 2000.
19. Kopp JB, Factor VM, Mozes M, Nagy P, Sanderson M, Bottinger EP, Klotman PE, and Thorgeirsson SS. Transgenic mice with increased plasma levels of TGF-β1 develop progressive renal disease. Lab Invest 74: 991-1003, 1996.
20. Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, Guize L, Ducimetiere P, and Benetos A. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 37: 1236-1241, 2001.
21. Laurent S, Katsahian S, Fassot C, Tropeano AI, Gautier I, Laloux B, and Boutouyrie P. Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Stroke 34: 1203-1206, 2003.
22. Liu RH, Mizuta M, Kurose T, and Matsukura S. Early events involved in the development of insulin resistance in Zucker fatty rat. Int J Obes Relat Metab Disord 26: 318-326, 2002.
23. Macdonald DA. Blood Flow in Arteries. Baltimore, MD: Williams & Wilkins, 1960, p. 146-176.
24. Meaume S, Benetos A, Henry OF, Rudnichi A, and Safar ME. Aortic pulse wave velocity predicts cardiovascular mortality in subjects greater than 70 years of age. Arterioscler Thromb Vasc Biol 21: 2046-2050, 2001.
25. Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Ishisaki A, Oeda E, Tamaki K, Hanai J, Heldin CH, Miyozono K, and ten Dijke P. TGF-β receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J 16: 5353-5362, 1997.
26. Noma T, Mizushige K, Yao L, Yu Y, Kiyomoto H, Hosomi N, Kimura S, Abe Y, Ohmori K, and Matsuo H. Alteration in aortic wall stiffness and accumulation of collagen during the prediabetic stage of type II diabetes mellitus in rats. Jpn Circ J 63: 988-993, 1999.
27. Pfeifle B and Ditshuneit A. Effect of insulin on growth of cultured human arterial smooth muscle cells. Diabetologia 20: 155-158, 1981.
28. Reaven GM. Pathophysiology of insulin resistance in human disease. Physiol Rev 75: 473-486, 1995.
29. Reed MJ, Meszaros K, Entes LJ, Claypool MD, Pinkett JG, Gadbois TM, and Reaven GM. A new rat model of type 2 diabetes: the fat-fed, streptozotocin- treated rat. Metabolism 49: 1390-1394, 2000.
30. Ridray S, Heudes D, Michel O, Penicaud L, and Ktorza A. Increased SMC proliferation after endothelial injury in hyperinsulinemic obese Zucker rats. Am J Physiol Heart Circ Physiol 267: H1976-H1983, 1994.
31. Ruiz-Torres A. The role of insulin-like growth factor 1 and insulin in ageing and atherosclerosis. Novartis Found Symp 242: 143-153, 2002.
32. Salomaa V, Riley W, Kark JD, Nardo C, and Folsom AR. Non-insulin- dependent diabetes mellitus and fasting glucose and insulin concentrations are associated with arterial stiffness indexes. Circulation 91: 1432-1443, 1995.
33. Sanderson N, Factor V, Nagy P, Kopp J, Kondaiah P, Wakefield L, Roberts AB, Sporn MD, and Thorgeirsson SS. Hepatic expression of mature transforming growth factor β1 in transgenic mice results in multiple tissue lesions. Proc Natl Acad Sci USA 92: 2572-2576, 1995.
34. Schram MT, Henry RM, Van Dijk RA, Kostense PJ, Dekker JM, Nijpels G, Heine RJ, Bouter LM, Westerhof N, and Stehouwer CD. Increased central artery stiffness in impaired glucose metabolism and type 2 diabetes: The Hoorn Study. Hypertension 43: 176-181, 2004.
35. Shoji T, Emoto M, Shinohara K, Kakiya R, Tsujimoto Y, Kishimoto H, Ishimura E, Tabata T, and Nishizawa Y. Diabetes mellitus, aortic stiffness, and cardiovascular mortality in end-stage renal disease. J Am Soc Nephrol 12: 2117-2124, 2001.
36. Singer AJ and Clark RAF. Cutaneous wound healing. N Engl J Med 341: 738-746, 1999.
37. Wrana JL, Attisano L, Wieser R, Ventura F, and Massague J. Mechanism of activation of the TGF-β receptor. Nature 370: 341-347, 1994.