Discovery of hydroxamic acid analogs as dual inhibitors of phosphodiesterase-1 and -5

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 18, 2005, Pages 4085-4090

  Dan, Akihito ^a   Shiyama, Takaaki ^a   Yamazaki, Kazuto ^a   Kusunose, Naoto ^a   Fujita, Katsuya ^a   Sato, Hideshi ^a   Matsui, Kazutaka ^a   Kitano, Masafumi ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

Phosphodiesterase

Indexed keywords

HYDROXAMIC ACID DERIVATIVE; PHOSPHODIESTERASE I; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE V; PHOSPHODIESTERASE V INHIBITOR;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; RAT;

CYCLIC GMP; HYDROXAMIC ACIDS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 23644451636     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.06.016     Document Type: Article

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8. +.
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