Novel peptide derivatives of bleomycin A5: Synthesis, antitumor activity and interaction with DNA

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 18, 2005, Pages 3996-3999

  Xu, Zhi Dong ^a,b   Wang, Min ^a,b   Xiao, Su Long ^a   Yang, Ming ^a  

^a PEKING UNIVERSITY   (China)

^b HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Antitumor; Bleomycin; DNA interaction

Indexed keywords

AMINO ACID; BLEOMYCIN A5; BLEOMYCIN DERIVATIVE; PEPTIDE DERIVATIVE; SINGLE STRANDED DNA;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CONTROLLED STUDY; DERIVATIZATION; DNA BINDING; DNA CLEAVAGE; DRUG DNA BINDING; DRUG DNA INTERACTION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYDROPHOBICITY; IN VITRO STUDY; PROMYELOCYTIC LEUKEMIA; PROSTATE CARCINOMA; PROTEIN CONFORMATION; PROTEIN FUNCTION; STOMACH CARCINOMA;

ANTINEOPLASTIC AGENTS; BLEOMYCIN; CELL LINE, TUMOR; DNA; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; NUCLEIC ACID DENATURATION; PEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE;

EID: 23644447202     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.06.021     Document Type: Article

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