Apolipoprotein E polymorphism in diabetic and non-diabetic patients: Does it really contribute to atherosclerosis?

Acta Cardiologica

Volumn 60, Issue 4, 2005, Pages 409-414

  Çamsari, Ahmet ^a   Tamer, Lülüfer ^a   Aras Ateş, Nurcan ^a   Pekdemir, Hasan ^a   Çiçek, Dilek ^a   Ercan, Bahadir ^a   Çamdeviren, Handan ^a   Atik, Ugur ^a  

^a MERSIN UNIVERSITY   (Turkey)

Author keywords

Apolipoprotein E; Arteriosclerosis; Polymorphism; Type 2 diabetes

Indexed keywords

APOLIPOPROTEIN A; APOLIPOPROTEIN E; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; LIPID; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; CHEMICAL ANALYSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENZYME POLYMORPHISM; FEMALE; GENOTYPE; HUMAN; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; REAL TIME POLYMERASE CHAIN REACTION; TRIACYLGLYCEROL BLOOD LEVEL;

ALLELES; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CHOLESTEROL; DIABETES MELLITUS, TYPE 2; FEMALE; GENOTYPE; HUMANS; LIPIDS; LIPOPROTEINS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; RISK FACTORS;

EID: 23644445204     PISSN: 00015385     EISSN: None     Source Type: Journal    
DOI: 10.2143/AC.60.4.2004990     Document Type: Article

References (29)

1. Chait A, Brunzell JD. Diabetes, lipids, and atherosclerosis. In: LeRoith D, Taylor SI, Olefsky JM (eds) Diabetes mellitus: a fundamental and clinical text. Philadelphia, Lippincott-Raven, 1996: 772-80.
2. Johansson S, Bondjers G, Fager G, Wedel H, Tsipogianni A, Olofsson SO, Vedin A, Wiklund O, Wilhelmsson C. Serum lipids with apolipoprotein levels in women with acute myocardial infarction. Arteriosclerosis 1988; 8: 742-9.
3. Chivot L, Mainard F, Bigot E, Bard JM, Auget JL, Madec Y, Fruchart JC. Logistic discriminant analysis of lipids and apolipoproteins in a population of coronary bypass patients and the significance of apolipoproteins C-III and E. Atherosclerosis 1990; 82: 205-11.
4. Klein RL, Lopes-Virella MF Metabolism by human endothelial cells of very low density lipoprotein subfractions isolated from type 1 (insulin-dependent) diabetic patients. Diabetologia 1993; 36: 258-64.
5. Syvanne M, Rosseneu M, Labeur C, Hilden H, Taskinen M-R. Enrichment with apolipoprotein E characterizes post-prandial TG-rich lipoproteins in patients with non-insulin-dependent diabetes mellitus and coronary artery disease; a preliminary report. Atherosclerosis 1994; 105: 25-34.
6. Weisweiler P, Schwandt P. Type 1 (insulin-dependent) versus type 2 (non-insulin-dependent) diabetes mellitus: characterization of serum lipoprotein alterations. Eur J Clin Invest 1987; 17: 87-91.
7. Scott J, Knott TJ, Shaw DJ, Brook JD. Localization of genes encoding apolipoproteins CI, CII, and E to the p13-cen region of human chromosome 19. Hum Genet 1985; 71: 144-6.
8. Dzimiri N, Meyer BF, Hussain SS, Basco C, Afrane B, Halees Z. Relevance of apolipoprotein E polymorphism for coronary artery disease in the Saudi population. Arch Pathol Lab Med 1999; 123: 1241-5.
9. Ashavaid TF, Todur SP, Nair KG Apolipoprotein E polymorphism and coronary heart disease. J Assoc Physicians India 2003; 51: 784-8.
10. Hanis CL, Hewett-Emmett D, Douglas TC, Bertin TK, Schull WJ. Effects of the apolipoprotein E polymorphism on levels of lipids, lipoproteins and apolipoproteins among Mexican-Americans in Starr County, Texas. Arterioscler Thromb 1991; 11: 362-70.
11. Siest G, Pillot T, Regis-Bailly A, Leininger-Muller B, Steinmetz J, Galteau MM, Visvikis S. Apolipoprotein E: an important gene and protein to follow in laboratory medicine. Clin Chem 1995; 41: 1068-86.
12. Menzel HJ, Kladetzky RG, Assmann G. Apolipoprotein E polymorphism and coronary artery disease. Arteriosclerosis 1983; 3: 310-5.
13. Utermann G. Apolipoprotein E polymorphism in health and disease. Am Heart J 1987; 113: 433-40.
14. Kesaniemi YA, Ehnholm C, Miettinen TA. Intestinal cholesterol absorption efficiency in man is related to apolipoprotein E phenotype. J Clin Invest 1987; 80: 578-81.
15. Corbo R, Vilardo T, Ruggeri M, Gemma AT, Scacchi R. Apolipoprotein E genotype and plasma levels in coronary artery disease. A case-control study in the Italian population. Clin Biochem 1999; 32: 217-22.
16. Friedewald WD, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499-502.
17. Davignon J, Gregg RE, Sing CF. Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis 1988; 8: 1-21.
18. Wilson PW, Schaefer EJ, Larson MG, Ordovas JM. Apolipoprotein E alleles and risk of coronary disease: a meta-analysis. Arterioscler Thromb Vasc Biol 1996; 16: 1250-5.
19. Kessler C, Spitzer C, Stauske D, Mende S, Stadlmuller J, Walther R, Rettig R. The apolipoprotein E and beta-fibrinogen G/A-455 gene polymorphisms are associated with ischemic stroke involving large-vessel disease. Arterioscler Thromb Vasc Biol 1997; 17: 2880-4.
20. Hixon JE. Apolipoprotein E polymorphisms affect atherosclerosis in young males. Arterioscler Thromb 1991; 11: 1237-44.
21. Terry JG, Howard G, Mercuri M, Bond MG, Crouse JR. Apolipoprotein E polymorphism is associated with segment-specific extracranial carotid artery intima-media thickening. Stroke 1996; 27: 1755-9.
22. Xiang G, Hu T, Wang Y. Apolipoprotein E genotypes and carotid artery atherosclerosis in type 2 diabetes mellitus. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2003; 20: 66-8 [in Chinese].
23. Gerdes LU, Gerdes C, Kervinen K, Savolainen M, Klausen IC, Hansen PS, Kesaniemi YA, Faergeman O. The apolipoprotein epsilon4 allele determines prognosis and the effect on prognosis of simvastatin in survivors of myocardial infarction: a substudy of the Scandinavian simvastatin survival study. Circulation 2000; 101: 1366-71.
24. Muls E, Vansant G, Beirinckx AM, Jans I. Dietary fat intake in relation to apo E isoforms and body fat distribution in obese women. Acta Cardiol 1993; 48: 473-5.
25. Vansant G, Mertens A, Muls E. The effect of atorvastatin on postprandial lipaemia in overweight or obese women homozygous for apo E3. Acta Cardiol 2001; 56: 149-54.
26. Humphries SE, Talmud PJ, Hawe E, Bolla M, Day IN, Miller GJ. Apolipoprotein E4 and coronary heart disease in middle-aged men who smoke: A prospective study. Lancet 2001; 358: 115-9.
27. Hsieh MC, Lin SR, Yang YC, Chen HC, Lin JN, Shin SJ. Higher frequency of apolipoprotein E2 allele in type 2 diabetic patients with nephropathy in Taiwan. J Nephrol 2002; 15: 368-73.
28. Guz G, Ozdemir FN, Sezer S, Isiklar I, Arat Z, Turan M, Haberal M. Effect of apolipoprotein E polymorphism on serum lipid, lipoproteins, and atherosclerosis in hemodialysis patients. Am J Kidney Dis 2000; 36: 826-36.
29. Kolovou G, Daskalova D, Mikhailidis DP. Apolipoprotein E polymorphism and atherosclerosis. Angiology 2003; 54: 59-71.