No increased susceptibility to breast cancer from combined CHEK2 1100delC genotype and the HLA class III region risk factors

European Journal of Cancer

Volumn 41, Issue 12, 2005, Pages 1819-1823

  De Jong, Mirjam M ^a   Nolte, Ilja M ^a   Te Meerman, Gerard J ^a   Van Der Graaf, Winette T A ^a   Oosterom, Elvira ^a   Bruinenberg, Marcel ^a   Van Der Steege, Gerrit ^a   Oosterwijk, Jan C ^a   Van Der Hout, Annemarie H ^a   Boezen, H Marike ^a   Schaapveld, Michael ^b   Kleibeuker, Jan H ^a   De Vries, Elisabeth G E ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b Integraal Kankercentrum Noord Nederland   (Netherlands)

Author keywords

1100delC mutation; Breast cancer; CHEK2; HLA class III region; Sporadic

Indexed keywords

CHECKPOINT KINASE 2; HLA ANTIGEN;

ARTICLE; BREAST CANCER; CANCER RISK; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MUTATION; PRIORITY JOURNAL; RISK FACTOR;

ADULT; AGED; ANALYSIS OF VARIANCE; BREAST NEOPLASMS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HLA ANTIGENS; HUMANS; MIDDLE AGED; MUTATION; PROTEIN-SERINE-THREONINE KINASES; RISK FACTORS;

EID: 23644442729     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2005.04.035     Document Type: Article

References (16)

1. D.M. Parkin Epidemiology of cancer: global patterns and trends Toxicol Lett 102-103 1998 227 234
2. M. Aubele, and M. Werner Heterogeneity in breast cancer and the problem of relevance of findings Anal Cell Pathol 19 1999 53 58
3. M.M. de Jong, I.M. Nolte, and G.J. te Meerman Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility J Med Genet 39 2002 225 242
4. J. Xu, S. Xin, and W. Du Drosophila Chk2 is required for DNA damage-mediated cell cycle arrest and apoptosis FEBS Lett 508 2001 394 398
5. N.H. Chehab, A. Malikzay, and M. Appel Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53 Genes Dev 14 2000 278 288
6. A. Hirao, Y.Y. Kong, and S. Matsuoka DNA damage-induced activation of p53 by the checkpoint kinase Chk2 Science 287 2000 1824 1827
7. S. Matsuoka, M. Huang, and S.J. Elledge Linkage of ATM to cell cycle regulation by the Chk2 protein kinase Science 282 1998 1893 1897
8. A.L. Brown, C.H. Lee, and J.K. Schwarz A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage Proc Natl Acad Sci USA 96 1999 3745 3750
9. J.S. Lee, K.M. Collins, and A.L. Brown hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response Nature 404 2000 201 204
10. H. Meijers-Heijboer, A. van den Ouweland, and J. Klijn Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations Nat Genet 31 2002 55 59
11. P. Vahteristo, J. Bartkova, and H. Eerola A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer Am J Hum Genet 71 2002 432 438
12. The CHEK2 Breast Cancer Case-Control Consortium CHEK2*1100delC and susceptibility to breast cancer: a collaborative analysis involving 10,860 breast cancer cases and 9,065 controls from 10 studies Am J Hum Genet 74 2004 1175 1182
13. M. Schutte, S. Seal, and R. Barfoot Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility Am J Hum Genet 72 2003 1023 1028
14. M.R. Dufault, B. Betz, and B. Wappenschmidt Limited relevance of the CHEK2 gene in hereditary breast cancer Int J Cancer 110 2004 320 325
15. B. Kuschel, A. Auranen, and C.S. Gregory Common polymorphisms in checkpoint kinase 2 are not associated with breast cancer risk Cancer Epidemiol Biomarkers Prev 12 2003 809 812
16. M.M. de Jong, I.M. Nolte, and E.G.E. de Vries The HLA class III subregion is responsible for an increased breast cancer risk Hum Mol Genet 12 2003 2311 2319