Positive pressure infusion of therapeutic agents into brain tissues: Mathematical and experimental simulations

Technology and Health Care

Volumn 13, Issue 4, 2005, Pages 235-243

  Gillies, George T ^a,b   Smith, Joshua H ^a   Humphrey, Joseph A C ^a   Broaddus, William C ^b  

^a University of Virginia   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN TISSUE; CENTRAL NERVOUS SYSTEM; DRUG DELIVERY SYSTEM; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; NEUROSURGERY; PRIORITY JOURNAL; REVIEW; SIMULATION; THEORETICAL MODEL;

EID: 23644438204     PISSN: 09287329     EISSN: None     Source Type: Journal    
DOI: 10.3233/thc-2005-13403     Document Type: Review

References (17)

1. W.C. Broaddus, G.T. Gillies and J. Kucharczyk, Advances in image-guided delivery of drug and cell therapies into the central nervous system, Neuroimaging Clinics of North America 11 (2001), 727-735.
2. E.A. Chiocca, W.C. Broaddus, G.T. Gillies, T. Visted and M.L.M. Lamfers, Neurosurgical delivery of chemotherapeutics, targeted toxins, genetic and viral therapies in neuro-oncology, Journal of Neuro-Oncology 69 (2004), 101-117.
3. G.T. Gillies, R.C. Ritter, W.C. Broaddus, M.S. Grady, M.A. Howard III. and R.G. McNeil, Magnetic manipulation instrumentation for medical physics research, Review of Scientific Instruments 65 (1994), 533-562.
4. M.S. Grady, M.A. Howard, III., J.A. Molloy, R.C. Ritter, E.G. Quate and G.T. Gillies, Preliminary experimental investigation of in vivo magnetic manipulation: Results and potential application in hyperthermia, Medical Physics 16 (1989), 263-272.
5. M.S. Grady, M.A. Howard, III., J.A. Molloy, R.C. Ritter, E.G. Quate and G.T. Gllies, Nonlinear magnetic stereotaxis: Three-dimensional in vivo remote magnetic manipulation of a small object in canine brain, Medical Physics 17 (1990), 405-415.
6. M.S. Grady, M.A. Howard, III., R.G. Dacey, W. Blume, M.A. Lawson, P.R. Werp and R.C. Ritter, Experimental study of the magnetic stereotaxis system for catheter manipulation within the brain, Journal of Neurosurgery 93 (2000), 282-288.
7. C. Nicholson, Diffusion and related transport mechanisms in brain tissue, Reports on Progress in Physics 64 (2001), 815-884.
8. G.T. Gillies, S.W. Allison and B.M. Tissue, Positive pressure infusion of fluorescent nanoparticles as a probe of the structure of brain phantom gelatins, Nanotechnology 13 (2002), 484-486.
9. G.T. Gillies, T.D. Wilhelm, J.A.C. Humphrey, H.L. Fillmore, K.L. Holloway and W.C. Broaddus, Spinal cord surrogate with nanoscale porosity for in vitro simulations of restorative neurosurgical techniques, Nanotechnology 13 (2002), 587-591.
10. Z.J. Chen, G.T. Gillies, W.C. Broaddus, S.S. Prabhu, H.L. Fillmore, R.M. Mitchell, F.D. Corwin and P.P. Fatouros, A realistic brain tissue phantom for intraparenchymal infusion studies, Journal of Neurosurgery 101 (2004), 314-322.
11. M.A. Bauman, G.T. Gillies, R. Raghavan, M.L. Brady and C. Pedain, Physical characterization of neurocatheter performance in a brain phantom gelatin with nanoscale porosity: stead-state and oscillatory flows, Nanotechnology 15 (2004), 92-97.
12. Z.J. Chen, W.C. Broaddus, R.R. Viswanathan, R. Raghavan and G.T. Gillies, Intraparenchymal drug delivery via positive-pressure infusion: experimental and modeling studies of poroelasticity in brain phantom gels, IEEE Transactions on Biomedical Engineering 49 (2002), 85-96.
13. R.A. Freeze and J.A. Cherry, Groundwater, Prentice-Hall, Inc., New York, 1979.
14. P.J. Haar, J.E. Stewart, G.T. Gillies, S.S. Prabhu and W.C. Broaddus, Quantitative three-dimensional analysis and diffusion modeling of oligonucleotide concentrations after direct intraparenchymal brain infusion, IEEE Transactions on Biomedical Engineering 48 (2001), 560-569.
15. P.J. Basser, Interstitial pressure, volume, and flow during infusion into brain tissue, Microvascular Research 44 (1992), 143-165.
16. K.D. Paulsen, M.I. Miga, F.E. Kennedy, P.J. Hoopes, A. Hartov and D.W. Roberts, A computational model for tracking subsurface tissue deformation during stereotactic surgery, IEEE Transactions on Biomedical Engineering 46 (1999), 213-225.
17. C.C. Yu and J.C. Heinrich, Petrov-Galerkin methods for the time-dependent convective transport equation, International Journal of Numerical Methods in Engineering 23 (1986), 883-901.