Simultaneous determination of clobazam and its major metabolite in human plasma by a rapid HPLC method

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 823, Issue 2, 2005, Pages 167-171

  Rouini, Mohammadreza ^a   Ardakani, Yalda H ^a   Hakemi, Lida ^a   Mokhberi, Maryam ^a   Badri, Gheise ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Clobazam; Monolithic; N Desmethylclobazam; Pharmacokinetics; Plasma

Indexed keywords

BODY FLUIDS; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLITES; PHARMACOKINETICS; TOLUENE;

CLOBAZAM; D-DESMETHYLCLOBAZAM; HUMAN PLASMA; MONOLITHIC;

DRUG PRODUCTS;

ACETONITRILE; ANTICONVULSIVE AGENT; BUFFER; CLOBAZAM; DRUG METABOLITE; NORCLOBAZAM; PHOSPHATE; TOLUENE;

ACCURACY; ARTICLE; CALIBRATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DRUG BLOOD LEVEL; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LIQUID LIQUID EXTRACTION; MEASUREMENT; NORMAL HUMAN; PH; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SAMPLE; SEPARATION TECHNIQUE; SPIKE WAVE; STATISTICAL MODEL; VALIDATION PROCESS; VOLUNTEER;

ANTICONVULSANTS; AREA UNDER CURVE; BENZODIAZEPINES; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; HALF-LIFE; HUMANS; REPRODUCIBILITY OF RESULTS;

EID: 23644436666     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2005.06.031     Document Type: Article

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