The development and characterisation of triglyceride-based 'spontaneous' multiple emulsions

International Journal of Pharmaceutics

Volumn 300, Issue 1-2, 2005, Pages 76-88

  Devani, Manisha J ^b   Ashford, Marianne ^c   Craig, Duncan Q M ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c ASTRAZENECA   (United Kingdom)

Author keywords

Lipid; Microscopy; Multiple emulsion; Particle size; Triglyceride

Indexed keywords

LABRAFAC LIPOPHILE; OIL; PEGLICOL 5 OLEATE; POLYSORBATE 80; SURFACTANT; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE; WATER;

AQUEOUS SOLUTION; ARTICLE; CHEMICAL COMPOSITION; CRYSTAL STRUCTURE; DRUG STABILITY; EMULSION; INTESTINE FLUID; LIPOLYSIS; PARTICLE SIZE; PH MEASUREMENT; PRIORITY JOURNAL; SIMULATION;

CHEMISTRY, PHARMACEUTICAL; DRUG STABILITY; EMULSIONS; HYDROGEN-ION CONCENTRATION; LIPOLYSIS; PARTICLE SIZE; TRIGLYCERIDES;

EID: 23444458748     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2005.05.011     Document Type: Article

References (33)

1. C.M. Adeyeye, and J.C. Price Effect of non-ionic surfactant concentration and type on the formation and stability of w/o/w multiple emulsions: microscopic and conductometric evaluation Drug Dev. Ind. Pharm. 17 1991 725 736
2. M.O. Bachynsky, N.H. Shah, C.I. Patel, and A.W. Malick Factors affecting the efficiency of a self-emulsifying oral delivery system Drug Dev. Ind. Pharm. 23 1997 809 816
3. B. Borgstrom, and C. Erlanson Pancreatic lipase and colipase: interactions and effects of bile salts and other detergents Eur. J. Biochem. 37 1973 60 68
4. B. Borgstrom The action of bile salts and other detergents on pancreatic lipase and the interaction with colipase Biochim. Biophys. Acta 1977 381 391
5. B. Borgstrom, and C. Erlanson-Albertsson Pancreatic colipase B. Borgstrom H.L. Brockman Lipases 1984 Elsevier Amsterdam 151 184
6. A. Bozkir, and G. Hayta Preparation and evaluation of multiple emulsions water-in-oil-in-water (w/o/w) as delivery system for influenza virus antigens J. Drug Targ. 12 2004 157 164
7. C.W. Chiang, G.C. Fuller, J.W. Frankenfeld, and C.T. Rhodes Potential of liquid membranes for drug overdose treatment: in vitro studies J. Pharm. Sci. 67 1978 63 66
8. F. Cournarie, M.P. Savelli, W. Rosilio, F. Bretez, C. Vauthier, J.L. Grossiord, and M. Seiller Insulin-loaded W/O/W multiple emulsions: comparison of the performances of systems prepared with medium-chain-triglycerides and fish oil Eur. J. Pharm. Biopharm. 58 2004 477 482
9. D.M.Q. Craig, K.Y. Agnes, and N. Khan A comparison of the self-emulsifying properties of polyglycolysed glyceride oils Pharm. Sci. 1 1995 559 561
10. M. Devani, M. Ashford, and D.Q.M. Craig The emulsification and solubilisation properties of polyglycolysed oils in self-emulsifying formulations J. Pharm. Pharmacol. 56 2004 307 316
11. J.B. Dressman, G.L. Amidon, C. Reppas, and V.P. Shah Dissolution testing as a prognostic tool for oral drug absorption: immediate release dosage forms Pharm. Res. 15 1998 11 22
12. J.K. Embleton, and C.W. Pouton Structure and function of gastro-intestinal lipase Adv. Drug Deliv. Rev. 25 1997 15 32
13. A.T. Florence, J.A. Omotosho, and T.L. Whateley Multiple w/o/w emulsions as drug vehicles Controlled Release of Drugs, Polymers and Aggregate Systems 1989 VCH Publishers Morton Rosoff
14. A.T. Florence, and D. Whitehill Some features of breakdown in water-in-oil-in-water multiple emulsions J. Colloid Interf. Sci. 79 1981 243 256
15. A.T. Florence, and D. Whitehill The formulation and stability of multiple emulsions Int. J. Pharm. 11 1982 277 308
16. N. Garti, and A. Aserin Double emulsions stabilised by macromolecular surfactants Adv. Coll. Int. Sci. 65 1996 37 69
17. Y. Kita, S. Matsumoto, and D. Yonezawa Viscometric method for estimating the stability of w/o/w type multiple phase emulsions J. Colloid Interf. Sci. 62 1977 87 94
18. C. Laugel, P. Chaminade, A. Baillet, M. Seiller, and D. Ferrier Moisturising substances entrapped in w/o/w emulsions: analytical methodology for formulation, stability and release studies J. Contr. Release 38 1996 59 67
19. M.E. Lowe The structure and function of pancreatic enzymes L.R. Johnson Physiology of the Gastrointestinal Tract 1994 Raven Press New York 1531 1542
20. K.J. MacGregor, J.K. Embleton, J.E. Lacy, E.A. Perry, L.J. Solomon, H. Seager, and C.W. Pouton Influence of lipolysis on drug absorption from the gastro-intestinal tract Adv. Drug Deliv. Rev. 1997 33 46
21. S. Magdassi, M. Frenkel, and N. Garti On the factors affecting the yield of preparation and stability of multiple emulsions J. Disper. Sci. Technol. 5 1984 49 59
22. S. Matsumoto, and M. Kohda The viscosity of w/o/w emulsions: an attempt to estimate the water permeation coefficient of the oil layer from the viscosity changes in diluted systems on ageing under osmotic pressure gradients J. Colloid Interf. Sci. 73 1980 13 20
23. J.L. Nano, and D. Sarvary Hydrolysis of an aliphatic monoester in emulsion by swine pancreatic lipase: influence of interfacial bile salts molecules upon reaction rate Biochimie 58 1976 917 928
24. P.B. O'Donnell, and J.W. McGinity Properties of multiphase microspheres of poly-(dl-lactic acid) or poly-(dl-lactic-co-glycolic acid) produced by mechanical agitation, sonication or potentiometric dispersion J. Microencapsul. 13 1996 667 677
25. T. Ohwaki, K. Nitta, H. Ozawa, Y. Kawashima, T. Hino, T. Hirofumi, and T. Niwa Improvement of the formation percentage of water-in-oil-in-water multiple emulsion by the addition of surfactants in the internal aqueous phase of the emulsion Int. J. Pharm. 85 1992 19 28
26. J.A. Omotosho, T.L. Whateley, T. Law, and A.T. Florence The nature of the oil phase and the release of solutes from multiple w/o/w emulsions J. Pharm. Pharmacol. 38 1986 865 870
27. N.H. Shah, M.T. Carvajal, C.I. Patel, M.H. Infeld, and A.W. Malik Self-emulsifying drug delivery systems (SEDDS) with polyglycolyzed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs Int. J. Pharm. 106 1994 15 23
28. L.J. Solomon, J.K. Embleton, and C.W. Pouton Inhibition of lipolysis of medium chain triglycerides by non-ionic surfactants, a structure activity study P. Couvreur D. Duchene I. Kalles Formulation of Poorly Available Drugs for Oral Administration 1996 Editions de Sante Paris
29. G.M. Tedajo, S. Bouttier, J. Fourniat, J.L. Grossiord, J.P. Marty, and M. Seiller Release of antiseptics from the aqueous compartments of a w/o/w multiple emulsion Int. J. Pharm. 288 2005 63 72
30. A. Vaziri, and B. Warburton Slow release of chloroquine phosphate from multiple taste-masked w/o/w multiple emulsions J. Microencapsul. 11 1994 641 648
31. A. Vaziri, and B. Warburton Improved stability of w/o/w multiple emulsions by addition of hydrophilic colloid components in the aqueous phases J. Microencapsul. 12 1995 1 5
32. D. Whitehill Multiple emulsions and their future uses Chemist and Druggist 1980 130 135
33. Y. Yamahira, T. Noguchi, H. Takenaka, and T. Maeda Biopharmceutical studies of lipid-containing oral dosage forms: relationship between drug absorption rate and digestibility of vehicles Int. J. Pharm. 3 1979 23 31