Interleukin-4 is not critical to pathogenesis in a mouse model of Pseudomonas aeruginosa corneal infection

Current Eye Research

Volumn 30, Issue 7, 2005, Pages 535-542

  Cole, Nerida ^a,b,c   Hume, Emma ^a,b   Khan, Shamila ^a   Krockenberger, Mark ^c   Thakur, Archana ^d   Husband, Alan J ^c   Willcox, Mark D P ^a,b  

^a Forest Research   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cornea; Gene knockout mice; IL 4; Pseudomonas aeruginosa

Indexed keywords

BREFELDIN A; CYTOKINE; FLUORESCENT DYE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 2; MYELOPEROXIDASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COUNT; CELL VIABILITY; CLINICAL OBSERVATION; CONTROLLED STUDY; HISTOPATHOLOGY; KERATITIS; KNOCKOUT MOUSE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; TH2 CELL; WILD TYPE;

ANIMALS; CHEMOKINES; COLONY COUNT, MICROBIAL; CYTOKINES; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EYE INFECTIONS, BACTERIAL; INTERLEUKIN-4; KERATITIS; LEUKOCYTE COUNT; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHILS; PEROXIDASE; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 23444457740     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1080/02713680590968583     Document Type: Article

References (34)

1. Leisgang TJ. Contact lens-related microbial keratitis: Part I: epidemiology. Cornea 1997;16:125-131.
2. Thakur A, Xue M, Stapleton F, Lloyd AR, Wakefield D, Willcox MDP. Balance of pro- and anti-inflammatory cytokines correlates with outcome of acute experimental Pseudomonas aeruginosa keratitis. Infect Immun. 2002;70:2187-2197.
3. Hazlett LD. Pathogenic mechanisms of P. aeruginosa keratitis: a review of the role of T-cells, Langerhans cells, PMN and cytokines. DNA and Cell Biol. 2002;21:383-390.
4. Kernacki KA, Barrett RP, Hobden JA, Hazlett LD. Macrophage inflammatory protein-2 is a mediator of polymorphonuclear neutrophil influx in ocular bacterial infection. J Immunol, 2000;164:1037-1045.
5. Cole N, Bao S, Thakur A, Willcox M, Husband AJ. KC production in the cornea in response to Pseudomonas aeruginosa challenge. Immunol Cell Biol. 2000;78:1-4.
6. Hazlett LD, Rudner XL, McClellan SA, Barrett RP, Lighvani S. Role of IL-12 and IFN-γ in Pseudomonas aeruginosa corneal infection. 2002; Invest Opthalmol Vis Sci. 2002;43:419-424.
7. Cole N, Bao S, Willcox M, Husband AJ. Expression of IL-6 in the cornea in response to infection with different strains of Pseudomonas aeruginosa. Infect Immun. 1999;67:2497-2502.
8. Cole N, Bao S, Stapleton F, Thakur A, Husband AJ, Beagley KW, Willcox MDP. Pseudomonas aeruginosa keratitis in IL-6-deficient mice. Allergy Immunol. 2003;130:165-172.
9. Cole N, Bao S, Willcox M, Husband AJ. TNF-α production in the cornea in response to Pseudomonas aeruginosa challenge, Immunol Cell Biol. 1999;77:164-166.
10. Cole N, Krockenberger M, Stapleton F, Khan S, Hume E, Husband AJ, Willcox M. Experimental Pseudomonas aeruginosa keratitis in IL-10 gene knockout mice. Infect Immun. 1999;67:2497-2502.
11. Hazlett LD, McClellan S, Kwon B, Barrett R. Increased severity of Pseudomonas aeruginosa corneal infection in strains of mice designated as Th1 versus Th2 responsive. Invest Opthalmol Vis Sci. 2000;41:805-810.
12. Nelms K, Keegan AD, Zamorano J, Ryan JJ, Paul WE. The IL-4 receptor: signalling mechanisms and biologic function. Ann Rev Immunol. 1999;17:701-738.
13. Vercelli D, Jabara HH, Lauener RP, Geha RS. IL-4 inhibits the synthesis of IFN-γ. J Immunol. 1990;144:570-573.
14. Hart PH, Vitti GF, Burgess DR, Whitty GA, Piccoli DS, Hamilton JA. Potential anti-inflammatory effects of IL-4: suppression of human monocyte tumour necrosis factor. Proc Natl Acad Sci USA. 1989;86:3803-3807.
15. Major J, Fletcher JE, Hamilton TA. IL-4 pretreatment selectively enhances cytokine and chemokine production in lipopolysaccharide-stimulated mouse peritoneal macrophages. J Immunol. 2002;168:2456-2463.
16. Takano Y, Fukagawa K, Shimmura S, Tsubota K, Oguchi Y, Saito H. IL-4 regulates chemokine production induced by TNF-α in keratocytes and corneal epithelial cells. Br J Opthalmol. 1999;83:1074-1076.
17. Bober LA, Rojas-Triana A, Jackson JV, Leach MW, Manfra D, Narula SK, Grace MJ. Regulatory effects of IL-4 and IL-10 on human neutrophil function ex-vivo and on neutrophil influx in a rat model of arthritis. Arth Rheum. 2000;43:2660-2667.
18. Boey H, Rosenbaum R, Castracane J, Borish L. Interleukin-4 is a neutrophil activator. J Allergy Clin Immunol. 1989;83:978-984.
19. Cenci E, Mencacci A, Del Sero G, Bacci A, Montagnoli C, d'Ostiani CF, Mosci P, Bachmann M, Bistoni F, Kopf M, et al. Interleukin-4 causes susceptibility to invasive pulmonary aspergillosis through suppression of protective type I responses. J Infect Dis. 1999;180:1957-1968.
20. Pearlman E, Lass JH, Bardenstein DS, Diaconu E, Hazlett FE, Albright J, Higgins AW, Kazura JW. Onchocerca volvulus- mediated keratitis: cytokine production by IL-4 deficient mice. Exp Parasit. 1996;84:274-281.
21. Jain-Vora S, LeVine AM, Chroneos Z, Ross GF, Hull WM, Whitsett JA, Interleukin-4 enhances pulmonary clearance of Pseudomonas aeruginosa. Infect Immun. 1998;66:4229-4236.
22. Giampietri A, Grohmann U, Vacca M, Fioretti MC, Puccetti P, Campanile F. Dual effect of IL-4 on resistance to systemic gram-negative infection and production of TNF-alpha. Cytokine. 2000;12:417-421.
23. Chen W, Shu D. Chadwick VS. Helicobacter pylori infection in interleukin-4-deficient and transgenic mice. Scand J Gastroenterol. 1999;34:987-992.
24. Kamradt AE, Greiner M, Ghiara P, Kaufmann SH. Helicobacter pylori infection in wild-type and cytokine-deficient C57BL/6 and BALB/c mouse mutants. Microbes Infect. 2000;2:593-597.
25. Garhart CA, Nedrud JG, Heinzel FP, Sigmund NE, Czinn SJ. Vaccine-induced protection against Helicobacter pylori in mice lacking both antibodies and interleukin-4. Infect Immun. 2003;71:3628-3633.
26. La Flamme AC, Patton EA, Pearce EJ. Role of gamma-interferon in the pathogenesis of severe schistosomiaisis in IL-4 deficient mice. Infect Immun. 2001;69:7445-7452.
27. Volkman L, Saeftel M, Bain O, Fischer K, Fleischer B, Hoerauf A. Interleukin-4 is essential for the control of microfilariae in murine infection with the filaria Litomosoides sigmodontis. Infect Immun. 2001;69:2950-2956.
28. Diehl S, Rincon M. The two faces of IL-6 on Th1/Th2 differentiation. Mol Immunol. 2002;39:531-536.
29. Hickey MJ, Granger DN, Kubes P. Molecular mechanisms underlying IL-4-induced leukocyte recruitment in vivo: a critical role for the alpha 4 integrin. J Immunol. 1999;163:3441-3448.
30. Marie C, Pitton C, Fitting C, Cavaillon JM. IL-10 and IL-4 synergize with TNF-alpha to induce IL-1ra production by human neutrophils. Cytokine. 1996;8:147-151.
31. Akira S, Hirano T, Taga T, Kishimoto T. Biology of multifunctional cytokines: II-6 and related molecules (II-1 and TNF). FASEB J. 1990;4:2860-2867.
32. Oquendo P, Alberta J, Wen DZ, Graycar JL, Derynck R, Stiles CD. The platelet-derived growth factor-inducible KC gene encodes a secretory protein related to platelet alpha-granule proteins. J Biol Chem. 1989;264:4133-4137.
33. Yan X-T, Tumpey TM, Kunkel SL, Oakes JE, Lausch RN. Role of MIP-2 in neutrophil migration and tissue injury in the herpes simplex virus-1-infected cornea. Invest Ophthalmol Vis Sci. 1998;39:1854-1862.
34. Hazlett LD, Huang X, McClellan SA, Barrett RP. Further studies on the role of IL-12 in Pseudomonas aeruginosa corneal infection. Eye. 2003;17:863-871.