The ratios of individual chemicals in a mixture determine the degree of joint effect: The climax hypothesis

Archives of Environmental Contamination and Toxicology

Volumn 49, Issue 1, 2005, Pages 1-8

  Lin, Z ^a,b   Ping, Z ^c   Kong, D ^d   Yin, K ^a   Cai, Z ^a  

^a SOUTH CHINA SEA INSTITUTE OF OCEANOLOGY   (China)

^b SOUTH CHINA SEA FISHERIES RESEARCH INSTITUTE   (China)

^c JINAN UNIVERSITY   (China)

^d National Environmental Protection Agency   (China)

Author keywords

[No Author keywords available]

Indexed keywords

PESTICIDE; XENOBIOTIC AGENT;

CHEMISTRY;

AGRICULTURE; ARTICLE; DETOXIFICATION; PREDICTION; PRIORITY JOURNAL; TOXICITY TESTING; VIBRIO FISCHERI; DOSE RESPONSE; DRUG EFFECT; DRUG INTERACTION; ENVIRONMENTAL EXPOSURE; GROWTH, DEVELOPMENT AND AGING; LUMINESCENCE; METHODOLOGY; STATISTICAL ANALYSIS; THEORETICAL MODEL; VIBRIO; WATER POLLUTANT;

VIBRIO FISCHERI;

DATA INTERPRETATION, STATISTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENVIRONMENTAL EXPOSURE; LUMINESCENT MEASUREMENTS; MODELS, THEORETICAL; TOXICITY TESTS; VIBRIO; WATER POLLUTANTS, CHEMICAL; XENOBIOTICS;

EID: 23444442076     PISSN: 00904341     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00244-003-0206-2     Document Type: Article

References (17)

1. SF Arnold DM Klotz BM Collins 1996 Synergistic activation of estrogen receptor with combinations of environmental chemicals Science 272 1489 1492
2. CY Chen CF Huang 1996 Toxicity of organic mixtures containing cyanogenic toxicants Environ Toxicol Chem 15 1464 1469
3. ER Christensen C Chen 1989 Modeling of combined toxic effects of chemicals. Hazard assessment of chemicals. Volume 6 Hemisphere Publishing New York 125 186
4. MTD Cronin BW Gregory TW Schultz 1998 Quantitative structure-activity analyses of nitrobenzene toxicity to Tetrahymena pyriformis Chem Res Toxicol 11 902 908
5. J Dong ZY Feng 1994 Joint effect of environmental pollutant. Shanghai Science and Technology Publishing Shanghai PRC 2 20
6. DJ Finney 1971 Probit analysis 3 Cambridge University Press London, England
7. PS Hewlett 1969 Measurement of the potencies of drug mixtures Biometrics 25 477 487
8. H Könemann 1981 Fish toxicity tests with mixtures of more than two chemicals: A proposal for a quantitative approach and observed results Toxicology 19 229 238
9. ZF Lin HX Yu SF Xu LS Wang 2001 Modification of the Photobacterium phosphoreum toxicity test method Environ Sci 22 114 117
10. RL Lipnick 1991 Outliers: Their origin and use in the classification of molecular mechanism of toxicity Science Total Environ 109/110 131 153
11. LL Marking 1977 Method for assessing additive toxicity of chemical mixtures, aquatic toxicology and hazard evaluation (publication no. 634) ASTM West Conshohocken, PA 99 108
12. APL Pamela JL Michael 1997 Synergistic toxicity of atrazine and organophosphate insecticides contravenes the response addition mixture model Environ Toxic Chem 16 2415 2420
13. RL Placket PS Hewlett 1967 A comparison of two approaches to the construction of models for quantal response to mixtures of drugs Biometrics 23 27 44
14. J Prakash N Nirmalakhandan B Sun J Peace 1996 Toxicity of binary mixtures of organic chemicals to microorganisms Water Res 30 1459 1463
15. JB Sprague BA Ramsay 1965 Lethal levels of mixed copper-zinc solutions for juvenile salmon J Fish Res Board Can 22 425 432
16. X Wang C Sun Y Wang L Wang 2002 Quantitative structure-activity relationships for the inhibition toxicity to root elongation of Cucumis sativus of selected phenols and interspecies correlation with Tetrahymena pyriformis Chemosphere 46 153 161
17. S Xu N Nirmalakhandan 1998 Use of QSAR models in predicting joint effects in multi-component mixtures of organic chemicals Water Res 32 2391 2399