Nitric oxide synthase inhibition alters cerebral blood flow and oxygen balance in focal cerebral ischemia in rats

Stroke

Volumn 25, Issue 2, 1994, Pages 445-449

  Wei, Hwu Meei ^a   Chi, Oak Za ^a   Liu, Xia ^b   Sinha, Arabinda K ^b   Weiss, Harvey R ^b  

^a Departments of Anesthesiology ^*  (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Cerebral arteries; Cerebral blood flow; Nitric oxide; Oxygen; Rats

Indexed keywords

NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN ARTERY; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; BRAIN OXYGEN CONSUMPTION; BRAIN PROTECTION; CONTROLLED STUDY; ENZYME REPRESSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

AMINO ACID OXIDOREDUCTASES; ANIMALS; ANTIPYRINE; ARGININE; BRAIN; CARBON RADIOISOTOPES; CEREBRAL ARTERIES; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; FUNCTIONAL LATERALITY; ISCHEMIC ATTACK, TRANSIENT; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; OXYGEN; OXYGEN CONSUMPTION; RATS; REFERENCE VALUES; REGIONAL BLOOD FLOW;

EID: 23444441150     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/01.STR.25.2.445     Document Type: Article

References (31)

1. Rees DD, Palmer RNJ, Schulz R, Hodson HF, Moncada S. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol. 1990;101:746-752.
2. Tanaka K, Gotoh F, Gomi S, Takashima S, Mihara B, Shirai T, Nogawa S, Nagata E. Inhibition of nitric oxide synthesis induces a significant reduction in local cerebral blood flow in the rat. Neuwsci Lett. 1991;127:129-132.
3. McCall T, Vallance P. Nitric oxide takes centre-stage with newly defined roles. Trends Pharmacol Sci. 1992;13:l-6.
4. Garthwaite J. Glutamate, nitric oxide and cell-cell signalling in the nervous system. Trends Neurosci. 1991;14:60-67.
5. Snyder SH, Bredt DS. Nitric oxide as a neuronal messenger. Trends Pharmacol Sci. 1991;12:125-128.
6. Yamamoto S, Golanov EV, Berger SB, Reis DJ. Inhibition of nitric oxide synthesis increases focal ischemic infarction in rat. J Cereb Blood Flow Metab. 1992;12:712-726.
7. Morikawa E, Huang Z, Moskowitz MA. L-Argjnine decreases infarct size caused by middle cerebral arterial occlusion in SHR. Am J Physiol. 1992;263 (Heart arc Physiol 32): H1632-H1635.
8. Nowicki JP, Dural D, Poignet H, Scotton B. Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse. Eur J Pharmacol. 1991;204:339-340.
9. Chi OZ, Anwar M, Sinha AK, Weiss HR. Effects of MK-801 on cerebral regional oxygen consumption in focal cerebral ischemia in rats. Brain Res. 1991;69:414-420.
10. Nishizaki T, Okada Y. Effects of excitatory amino acid on the oxygen consumption of hippocampal slices from the guinea pig. Brain Res. 1988;452:ll-20.
11. Dawson VL, Dawson TM, London ED, Bredt DS, Snyder SH. Nitric oxide mediates glutamate neurotcnricity in primary cortical cultures. Proc Natl Acad Sci USA. 1991;88:6368-6371.
12. Garthwaite J, Garthwaite G, Palmer RMJ, Moncada S. NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices. Eur J Pharmacol. 1989;172:413-416.
13. Tamura A, Graham DL, McCulloch J, Teasdale GM. Focal ischemia in the rat: description of the technique and early neuro-pathological consequences following middle cerebral artery occlusion. J Cereb Blood Flow Metab. 1981;l:53-60.
14. 14C]-iodoantipyrine. Am J Physiol. 1978;234:H59-H66.
15. 2 saturation determination in frozen tissue. Microvasc Res. 1977;14:133-144.
16. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 1992;6:3051-3064.
17. Peuigrino DA, Koenig HM, Albrecht RF. Nitric oxide synthesis and regional cerebral blood flow responses to hypercapnia and hypoxia in the rat J Cereb Blood Flow Metab. 1993;13:80-87.
18. Kozniewska E, Oseka M, Stys T. Effects of endothelium-derived nitric oxide on cerebral oreulation during normoxic and hypoxia in the rat. J Cereb Blood Flow Metab. 1992;12:311-317.
19. Toda N, Okamura T. Role of nitric oxide in neurally induced cerebroarterial relaxation. J Pharmacol Exp Ther. 1991;258:1027-1032.
20. G-nitro-L-arginine on cerebral blood flow response to changes in carbon dioxide tension. J Cereb Blood Flow Metab. 1992;2:947-953.
21. Wei HM, Weiss HR, Sinha AK, Chi OZ. Effects of nitric oiide synthase inhibition on regional cerebral blood flow and vascular resistance in conscious and isoflurane anesthetized rats. Anesth Analg. 1993;77:880-885.
22. Mellion BT, Ignarro LJ, Ohlstein EH, Pontecorvo EG, Hyman AL, Kadowitz PJ. Evidence for the inhibitory role of guanosine 3′, 5′-monophosphate in ADP-induced human platelet aggregation in the presence of nitric oxide and related vasodilators. Blood. 1981;57:946-955.
23. Radomski MW, Palmer RMJ, Moncada S. The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium. Biochem Biophys Res Commun. 1987;148:1482-1489.
24. Shapira S, Brandeis R, Weissman BA, Kactar T. The effects of NO synthase inhibitor on brain ischemia in vivo. Soc Neurosci Abs. 1992;18:645. Abstract.
25. Ichord RN, Kirsch JR, Helfaer MA Traystman RJ. Effect of nitric oxide synthase inhibition on cerebral hyperemia produced by hypo-glycemia in piglets. FASEB J. 1992;6:A1462. Abstract.
26. McPherson RW, Kirsch JR, Traystman R. Interaction of nitric oxide mediated vasodilation and alpha-2 mediated cerebral vasoconstriction during isoflurane anesthesia in the dog. FASEB J. 1992;6:A1461. Abstract.
27. Krasney JA, Yang SP, Yoshinaga M, Krasney E, Iwamoto J. Nitric oxide (NO) influences brain metabolism in awake sheep. FASEB J. 1992;6:A1264. Abstract.
28. Ginsberg MD, Reivich M. Use of the L-deoxyglucose method of local cerebral glucose utilization in abnormal brain: evaluation of the lumped constant during ischemia. Acta Neurol Scand. 1979;60:226-227.
29. Kader A, Frazzini VI, Solomon RA, Trifiletti RR. Nitric oxide production during focal ischemia in rats. Stroke. 1993;24:1709-1716.
30. Malinski T, Bailey F, Zhang ZG, Chopp M. Nitric oxide measured by a porphyrinic microsensor in rat brain after transient middle cerebral artery occlusion. J Cereb Blood Flow Metab. 1993;13:355-358.
31. Knowles RG, Palacios M, Palmer RMJ, Moncada S. Function of nitric oxide from L-arginine in the central nervous system, a trans-duction mechanism for stimulations of the soluble guanylate cyclase. Proc Natl Acad Sci USA. 1989;86:5139-5162.