Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

Cell

Volumn 76, Issue 4, 1994, Pages 761-775

  Roelink, H ^a   Augsburger, A ^a   Heemskerk, J ^a   Korzh, V ^b   Norlin, S ^b   Ruiz i Altaba, A ^a   Tanabe, Y ^a   Placzek, M ^c   Edlund, T ^b   Jessell, T M ^a   Dodd, J ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b UMEÅ UNIVERSITY   (Sweden)

^c NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; GENE EXPRESSION REGULATION; GENE SEQUENCE; HEDGEHOG; MOTONEURON; NERVE CELL DIFFERENTIATION; NONHUMAN; NOTOCHORD; PRIORITY JOURNAL; RAT; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; ZEBRA FISH;

ANIMALIA; ANURA; DANIO RERIO; ERINACEIDAE; VERTEBRATA;

EID: 23444440157     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(94)90514-2     Document Type: Article

References (91)

1. Maintenance of ZPA signaling in cultured mouse limb bud cells
2. Transcription of the segment-polarity gene wingless in the imaginal discs of Drosophila and the phenotype of a pupal-lethal wg mutation
3. Hedgehog, a product of posterior compartment cells in Drosophila, organizes anterior compartment pattern
4. Control of cell pattern in the neural tube regulation of cell differentiation by dorsalin-1 a novel TGFβ family member
5. XFKH2 a Xenopus HNF-3α homologue exhibits both activin inducible and autonomous phases of expression in early embryos
6. Perturbation of neuronal differentiation and axon guidance in the spinal cord of mouse embryos lacking a floor plate analysis of Danforth's short-tail mutation
7. Axis specification in the developing Drosophila appendage the role of wingless decapentaplegic and the homeobox gene aristaless
8. Molecular modeling of protein-glycosaminoglycan interactions
9. Neuroanatomical and functional analysis of neural tube formation in notochordless Xenopus embryos laterality of the ventral spinal cord is lost
10. Fate map for the 32-cell stage of Xenopus laevis
11. A wholemount immunocytochemical analysis of the expression of the intermediate filament vimentin in Xenopus
12. A novel activin-inducible blastopore lip specific gene of Xenopus laevis contains a fork head DNA-binding domain
13. Sonic hedgehog a member of a family of putative signaling molecules is implicated in the regulation of CNS polarity
14. Nucleotide sequence of the ospAB operon of a Borrelia burgdorferi strain expressing OspA but not OspB
15. Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1
16. decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo
17. Signals from the notochord and floor plate regulate the region-specific expression of two pax genes in the developing spinal cord
18. Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation
19. A series of normal stages in the development of chick embryo
20. In situ hybridization: an improved whole mount method for Xenopus embryos
21. The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system
22. The TGFβ homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina
23. Drosophila hedgehog acts as a morphogen in cellular patterning
24. Cell patterning in the Drosophila segment spatial regulation of the segment polarity gene patched
25. Evidence that Hensen's node is a site of retinoic acid synthesis
26. An autoradiographic study of the formation of the lateral motor column in the chick embryo
27. Maps of strength of positional signaling activity in the developing chick wing bud
28. Positional signalling by Hensen's node when grafted to the chick limb bud
29. Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo
30. Floor plate-derived signals and the control of neural cell pattern in vertebrates
31. F-spondin a gene expressed at high levels in the floor plate encodes a secreted protein that promotes neural cell adhesion and neurite extension
32. Activin A induced expression of a fork head related gene in posterior chordamesoderm of Xenopus laevis embryos
33. Zebrafish primary neurons initiate expression of the LIM homeodomain protein lsl-1 at the end of gastrulation
34. Expression pattern of zebrafish Pax genes suggests a role in early brain regionalization
35. A functionally conserved homolog of the Drosophila segment polarity gene hedgehog is expressed in tissues with polarizing activity in zebrafish embryos
36. A simple method for displaying the hydropathic character of a protein
37. Hepatocyte nuclear factor 3α belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head
38. Secretion and localization transcription suggest a role in positional signaling for products of the segmentation gene hedgehog
39. The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye
40. Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo
41. The Wnt-1 (int-1) protooncogene is required for development of a large region of the mouse brain
42. Requirements for hedgehog a segmental polarity gene in patterning larval and adult cuticle of Drosophila
43. Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila
44. Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 α β and γ genes in determination of the definitive endoderm chordamesoderm and neuroectoderm
45. The development of wingless a homeotic mutation of Drosophila
46. FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb
47. Wnt genes
48. Mutations affecting segment number and polarity in Drosophila
49. Mouse Wnt genes exhibit discrete domains of expression in its early embryonic CNS and limb buds
50. Expression of engrailed proteins in arthropods annelids and chordates
51. Orientation of commissural axons in vitro in response to a floor plate derived chemoattractant
52. Mesodermal control of neural cell identity floor plate induction by the notochord
53. Control of dorso-ventral pattern in vertebrate neural development induction and polarizing properties of the floor plate
54. Induction of floor plate differentiation by contact-dependent homeogenetic signals
55. Wing formation in Drosophila melanogaster requires decapentaplegic gene function along the anterior-posterior compartment boundary
56. Sonic hedgehog mediates the polarizing activity of the ZPA
57. Expression of two members of the Wnt family during mouse development restricted temporal and spatial patterns in the developing neural tube
58. Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis
59. Planar and vertical signals in the induction and patterning of the Xenopus nervous system
60. Xenopus
61. Pintallavis a gene expressed in the organizer and midline cells of frog embryos involvement in the development of the neural axis
62. Midline cells and the organization of the vertebrate neuraxis
63. Ectopic neural expression of a floor plate marker in frog embryos injected with the midline transcription factor Pintallavis
64. Sequential expression of HNF-3β and HNF-3α by embryonic organizing centers the dorsal lip/node notochord and floor plate
65. DNA sequencing with chain-terminating inhibitors
66. Differentiation expression of multiple fork head regulated genes during gastrulation and axial pattern formation in the mouse embryo
67. HNF-3β as a regulator of floor plate development
68. A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells in situ hybridization using digoxigeninlabeled cRNA probes
69. Decapentaplegic a gene complex affecting morphogenesis in Drosophila melanogaster
70. Hensen's node but not other biological signallers can induce supernumerary digits in the developing chick limb bud
71. Axial a target gene of mesoderm and neural induction shows altered expression in cyclops mutant zebrafish embryos
72. Organizing activity of wingless protein in Drosophila
73. The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation
74. Developmental changes in unique cell surface antigens of chick embryo spinal motor neurons and ganglion cells
75. Structure and expression of hedgehog a Drosophila segment-polarity gene required for cell-cell communication
76. Contrasting distributions of patched and hedgehog proteins in the Drosophila embryo
77. Chemotropic guidance of developing axons in the mammalian central nervous system
78. Identification and spatial distribution of retinoids in the developing chick limb bud
79. Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development
80. The homeodomain LIM protein Isl-1 is expressed in subsets of neurons and endocrine cells in the adult rat
81. Development of floor plate neurons and axonal outgrowth pattern in the early spinal cord of the notochord-deficient chick embryo
82. Effect of the notochord on the differentiation of a floor plate area in the neural tube of the chick embryo
83. FGF-4 maintains polarizing activity of posterior limb bud cells in vivo and in vitro
84. Signal sequences the limits of variation
85. Polarizing activity and retinoid synthesis in the floor plate of the neural tube
86. Regional differences in retinoid release from embryonic neural tissue detected by an in vitro reporter assay
87. The fork head domain a novel DNA binding motif of eukaryotic transcription factors?
88. Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-26 gene expression
89. Control of cell pattern in the developing nervous system polarizing activity of the floor plate and notochord
90. Control of cell pattern in the neural tube motor neuron induction by diffusible factors from notochord and floor plate