Percutaneous ethanol injection for small hepatocellular carcinoma: Therapeutic efficacy based on 20-year observation

Journal of Hepatology

Volumn 43, Issue 3, 2005, Pages 458-464

  Ebara, Masaaki ^a   Okabe, Shinichiro ^a   Kita, Kazuhiko ^a   Sugiura, Nobuyuki ^a   Fukuda, Hiroyuki ^a   Yoshikawa, Masaharu ^a   Kondo, Fukuo ^a   Saisho, Hiromitsu ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

Computed tomography; Hepatocellular carcinoma; Percutaneous ethanol injection; Prognosis; Survival; Therapy; Ultrasonography

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ALPHA FETOPROTEIN;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ADULT; AGED; ARTICLE; BILE DUCT OBSTRUCTION; BILIARY TRACT HEMORRHAGE; CANCER RECURRENCE; CANCER SURVIVAL; CHOLECYSTITIS; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DEATH; DISEASE SEVERITY; DRUG EFFICACY; FEMALE; HUMAN; HYPERTHERMIA; ILEUS; LIVER CELL CARCINOMA; LIVER FUNCTION; MAJOR CLINICAL STUDY; MALE; NONBIOLOGICAL MODEL; PAIN; PLEURA EFFUSION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RADIOFREQUENCY ABLATION; RELIABILITY; SAFETY; STATISTICAL SIGNIFICANCE; SURVIVAL RATE; THROMBOSIS; TUMOR VOLUME;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, HEPATOCELLULAR; ETHANOL; FEMALE; HUMANS; INJECTIONS, INTRALESIONAL; LIVER NEOPLASMS; MALE; MIDDLE AGED; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; TIME FACTORS;

EID: 23444439945     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2005.03.033     Document Type: Article

References (30)

1. K. Okuda Hepatocellular carcinoma: recent progress Hepatology 15 1992 948 963
2. J. Belghiti, O.A. Guevara, R. Noun, P.F. Saldinger, and R. Kianmanesh Liver hanging maneuver: a safe approach to right hepatectomy without liver mobilization J Am Coll Surg 193 2001 109 111
3. T.J. Song, E.W. Ip, and Y. Fong Hepatocellular carcinoma: current surgical management Gastroenterology 127 2004 248 260
4. S. Okada, K. Shimada, J. Yamamoto, T. Takayama, T. Kosuge, and S. Yamasaki Predictive factors for postoperative recurrence of hepatocellular carcinoma Gastroenterology 106 1994 1618 1624
5. N. Sugiura, K. Takara, M. Ohto, K. Okuda, and N. Hirooka Ultrasound-guided ethanol injection for the treatment of small hepatocellular carcinoma Acta Hepatol Jpn 21 1983 920 (in Japanese)
6. M. Ebara, M. Ohto, N. Sugiura, K. Kita, M. Yoshikawa, and K. Okuda Percutaneous ethanol injection for the treatment of small hepatocellular carcinoma. Study of 95 patients J Gastroenterol Hepatol 5 1990 616 626
7. J.C. Sheu, G.T. Huang, D.S. Chen, J.L. Sung, P.M. Yang, and T.C. Wei Small hepatocellular carcinoma: Intra tumor ethanol treatment using new needle and guidance systems Radiology 163 1987 43 48
8. T. Livraghi, D. Fest, F. Monti, A. Salmi, and C. Vettori US-guided percutaneous alcohol injection of small hepatic and abdominal tumors Radiology 161 1986 309 312
9. S. Shiina, K. Tagawa, Y. Niwa, T. Unuma, Y. Komatsu, and K. Yoshiura Percutaneous ethanol injection therapy for hepatocellular carcinoma: results in 146 patients AJR 160 1993 1023 1028
10. L. Buscarini, M. Di Stasi, E. Buscarini, F. Fornari, L. Squassante, and S. Rossi Clinical presentation, diagnostic work-up and therapeutic choices in two consecutive series of patients with hepatocellular carcinoma Oncology 53 1996 204 209
11. T. Livraghi, S.N. Goldberg, S. Lazzaroni, F. Meloni, L. Solbiati, and G.S. Gazelle Small hepatocellular carcinoma: treatment with radio-frequency ablation versus ethanol injection Radiology 210 1999 655 661
12. R.A. Lencioni, H.P. Allgaier, D. Cioni, M. Olschewski, P. Deibert, and L. Crocetti Small hepatocellular carcinoma in cirrhosis: Randomized comparison of radio-frequency thermal ablation versus percutaneous ethanol injection Radiology 228 2003 235 240
13. R.N. Pugh, I.M. Murray-Lyon, J.L. Dawson, M.C. Pietroni, and R. Williams Transection of the oesophagus for bleeding esophageal varices Br J Surg 60 1973 646 664
14. M. Ebara, K. Kita, N. Sugiura, M. Yoshikawa, H. Fukuda, and M. Ohto Therapeutic effect of percutaneous ethanol injection (PEI) on small hepatocellular carcinoma. Evaluation with CT Radiology 195 1995 371 377
15. I. Ikai, Y. Itai, K. Okita, M. Omata, M. Kojiro, and K. Kobayashi Report of the 15th follow-up survey of primary liver cancer Hepatol Res 28 2004 21 29
16. J.M. Llovet, R. Vilana, C. Brú, L. Bianchi, J.M. Salmeron, and L. Boix Increased risk of tumor seeding after percutaneous radiofrequency for single hepatocellular carcinoma Hepatology 33 2001 1124 1129
17. K. Kurokohchi, S. Watanabe, T. Masaki, N. Hosomi, T. Funaki, and K. Arima Combination therapy of percutaneous ethanol injection and radiofrequency ablation against hepatocellular carcinomas difficult to treat Int J Oncol 21 2002 611 615
18. H. Ishii, S. Okada, H. Nose, T. Okusaka, M. Yoshimori, and T. Takayama Local recurrence of hepatocellular carcinoma after percutaneous ethanol injection Cancer 77 1996 1792 1796
19. Y. Nakashima, O. Nakashima, M. Tanaka, K. Okuda, M. Nakashima, and M. Kojiro Portal vein invasion and intrahepatic micrometastasis in small hepatocellular carcinoma by gross type Hepatol Res 26 2003 142 147
20. T. Livraghi, S. Lazzaroni, and F. Meloni Radiofrequency thermal ablation of hepatocellular carcinoma Eur J Ultrasound 13 2001 159 166
21. S. Shiina, T. Teratani, S. Obi, K. Hamamura, Y. Koike, and M. Omata Percutaneous ethanol injection therapy for liver tumors Eur J Ultrasound 13 2001 95 106
22. T. Livraghi, A. Giorgio, G. Marin, A. Salmi, I. Sio, and L. Bolondi Hepatocellular carcinoma and cirrhosis in 746 patients: long-term results of percutaneous ethanol injection Radiology 197 1995 101 108
23. S.M. Lin, C.J. Lin, C.C. Lin, C.W. Hsu, and Y.C. Chen Radiofrequency ablation improves prognosis compared with ethanol injection for hepatocellular carcinoma <4 cm Gastroenterology 127 2004 1714 1723
24. M. Ryu, Y. Shimamura, T. Kinoshita, M. Konishi, N. Kawano, and M. Iwasaki Therapeutic results of resection, transcatheter arterial embolization and percutaneous transhepatic ethanol injection in 3225 patients with hepatocellular carcinoma: a retrospective multicenter study Jpn J Clin Oncol 27 1997 251 257
25. S. Arii, Y. Yamaoka, S. Futagawa, K. Inoue, K. Kobayashi, and M. Kojiro Results of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: a retrospective and nationwide survey in Japan Hepatology 32 2000 1224 1229
26. J. Yamamoto, S. Okada, K. Shimada, T. Okusaka, S. Yamasaki, H. Ueno, and T. Kosuge Treatment strategy for small hepatocellular carcinoma: comparison of long-term results after percutaneous ethanol injection therapy and surgical resection Hepatology 34 2001 707 713
27. Liver Cancer Group of Japan The general rules for the clinical and pathological study of primary liver cancer 2nd ed. 2003 Kanehara and Co. Ltd Tokyo p. 23-25
28. M. Sala, J.M. Llovet, R. Vilana, L. Bianchi, M. Sole, and C. Ayuso Initial response to percutaneous ablation predicts survival in patients with hepatocellular carcinoma Hepatology 40 2004 1352 1360
29. K. Takayasu, Y. Muramatsu, N. Moriyama, H. Hasegawa, M. Makuuchi, and N. Okazaki Clinical and radiologic assessments of the results of hepatectomy for small hepatocellular carcinoma and therapeutic arterial embolization for postoperative recurrence Cancer 64 1989 1848 1852
30. K. Ikeda, Y. Arase, M. Kobayashi, S. Saitoh, T. Someya, and T. Hosaka Significance of multicentric cancer recurrence after potentially curative ablation of hepatocellular carcinoma: a longterm cohort study of 892 patients with viral cirrhosis J Gastroenterol 38 2003 865 876