Studies on protective effect of total flavonoids of astragalus on liver damage paracetamol-inducedby

Zhongguo Zhongyao Zazhi

Volumn 26, Issue 7, 2001, Pages 485-486

  Wang, De Qing ^a,b   Ding, Bao Guo ^a   Ma, Yan Qing ^a   Zhao, Hai Lu ^a   Neil, Thomas G ^a   Brian, Tomlinson ^a   Tian, Ya Ping ^b   Wang, Cheng Bin ^b   Critchley, Julian Ajh ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Liver damage; Paracetamol; Total flavonoids of Astragalus; Vitamin C

Indexed keywords

ASCORBIC ACID; FLAVONOID; HERBACEOUS AGENT; PARACETAMOL; PROTECTIVE AGENT;

ANIMAL; ARTICLE; ASTRAGALUS MEMBRANACEUS; C57BL MOUSE; CHEMISTRY; ISOLATION AND PURIFICATION; LIVER; MALE; MEDICINAL PLANT; MOUSE; PATHOLOGY; PHYTOTHERAPY; TOXIC HEPATITIS;

ACETAMINOPHEN; ANIMALS; ASCORBIC ACID; ASTRAGALUS MEMBRANACEUS; DRUGS, CHINESE HERBAL; FLAVONOIDS; HEPATITIS, TOXIC; LIVER; MALE; MICE; MICE, INBRED C57BL; PHYTOTHERAPY; PLANTS, MEDICINAL; PROTECTIVE AGENTS;

EID: 23444436554     PISSN: 10015302     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Prescott L F. Paracetamol, Alcohol and the Liver. British Journal of Clinical Pharmacology, 2000,49(4):291.
2. Dahlin D C, Miwa G T, Lu A Y,et al. N-acetyl-p-benzoquinone Imine: a Cytochrome P-450-mediated Oxidation Product of Acetaminophen. Proceedings of the National Academy of Sciences of the United States of America, 1984,81 (5): 1327.
3. Poli G. Liver Damage Due to Free Radicals. British Medical Bul-letin, 1993,49(3):604.
4. Gilani A H, Janbaz K H, Akhtar M S. Selective Protective Effect of an Extract from Furnaria Parviflora on Paracetamol-Induced Hepatotoxicity. Genera Pharmacology, 1996,27(6):979.
5. Peterson F J, Knodell R G. Ascorbic Acid Protects Against Acetaminophen- and Cocaine-Induced Hepatic Damage in Mice. Drug-Nutrient Interactions, 1984,3( 1 ):33.
6. Lau G S, Critchley J A. The Estimation of Paracetamol and Its Major Metabolites in Both Plasma and Urine by a Single High-Performance Liquid Chromatography Assay. Journal of Pharmaceutical & Biomedical Analysis, 1994, 12(12): 1563.
7. Wang E J, Li Y, Lin M, et al. Protective Effects of Garlic and Related Organosulfur Compounds on Acetaminophen-Induced Hepatotoxicity in Mice. Toxicology & Applied Pharmacology, 1996,136(1):146.
8. Plaa G L, Hewitt W R. Quantitative Evaluation of Indices of Hepatotoxicity. Toxicology of the Liver. New York: Raven Press, 1982.103.
9. Van de Straat R, de Vries J, Debets A J, et al. The Mechanism of Prevention of Paracetamol-Induced Hepatotoxicity by 3,5-Dialkyl Substitution. The Roles of Glutathione Depletion and Oxidative Stress. Biochemical Pharmacology, 1987,36(13):2065.
10. Rose R C, Bode A M. Biology of Free Radical Scavengers: An Evaluation of Ascorbate. Faseb J, 1993,7(12):1135.
11. Van Dyke K, Sacks M, Qazi N. A New Screening Method to Detect Water-Soluble Antioxidants: Acetaminophen (Tylenol) and Cther Phenols React as Antioxidants and Destroy Peroxynitrite-Based Luminol-Dependent Chemiluminescence. Journal of Bioluminescence & Chemiluminescence,1998, 13(6):339.