A preliminary multi-stable-isotopic evaluation of three synthetic pathways of Topiramate

Journal of Pharmaceutical and Biomedical Analysis

Volumn 39, Issue 1-2, 2005, Pages 66-75

  Jasper, J P ^a   Weaner, L E ^b   Duffy, B J ^b  

^a Molecular Isotope Technologies LLC   (United States)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

13C; 15N; 18O; D; Active pharmaceutical ingredients; Pharmaceutical materials; Stable isotopes; Synthetic isotope fractionation; Synthetic pathways; Topiramate

Indexed keywords

CARBON 13; DEUTERIUM; NITROGEN 15; ORGANIC CARBON; OXYGEN 18; TOPIRAMATE; WATER;

ARTICLE; BATCH PROCESS; CARBON SOURCE; CHEMICAL COMPOSITION; CLUSTER ANALYSIS; CORRELATION ANALYSIS; DRUG SCREENING; DRUG STABILITY; ERROR; EXAMINATION; FRACTIONATION; LATITUDE; LINEAR SYSTEM; MARINE ENVIRONMENT; MATERIALS; PHOTOSYNTHESIS; PRIORITY JOURNAL; SAMPLE; STANDARD;

FRUCTOSE; ISOTOPES; REPRODUCIBILITY OF RESULTS;

EID: 23444433935     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2005.03.011     Document Type: Article

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