Construction of group sequential designs in clinical trials on the basis of detectable treatment differences

Statistics in Medicine

Volumn 23, Issue 9, 2004, Pages 1413-1424

  Schäfer, Helmut ^a   Müller, Hans Helge ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Clinical trial; Group sequential test; Interim analysis; Minimal clinically relevant difference; Sample size calculation

Indexed keywords

ALGORITHM; ARTICLE; BRAIN DEPTH STIMULATION; CANCER SURVIVAL; CLINICAL PROTOCOL; CLINICAL TRIAL; COMPUTER PROGRAM; EXPERIMENTAL DESIGN; HUMAN; HYPOTHESIS; LUNG NON SMALL CELL CANCER; MEDICAL ETHICS; OUTCOMES RESEARCH; PALLIDOTOMY; PARKINSON DISEASE; PROBABILITY; QUALITY OF LIFE; SAMPLE SIZE; SEQUENTIAL ANALYSIS; STATISTICAL ANALYSIS; SURVIVAL TIME;

ALGORITHMS; CARCINOMA, NON-SMALL-CELL LUNG; CLINICAL TRIALS; DATA INTERPRETATION, STATISTICAL; DECISION SUPPORT TECHNIQUES; ELECTRIC STIMULATION; HUMANS; LUNG NEOPLASMS; MODELS, STATISTICAL; PARKINSON DISEASE; QUALITY OF LIFE; RESEARCH DESIGN; SAMPLE SIZE; SURVIVAL RATE;

EID: 2342658477     PISSN: 02776715     EISSN: None     Source Type: Journal    
DOI: 10.1002/sim.1751     Document Type: Article

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