The disruption of the third extracellular loop of the red cell anion exchanger AE1 does not affect electroneutral Cl-/HCO3 - exchange activity

Blood Cells, Molecules, and Diseases

Volumn 32, Issue 3, 2004, Pages 379-383

  Parker, Mark D ^a,b   Tanner, Michael J A ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AE1; Anion exchanger; SLC4A1; Xenopus oocyte

Indexed keywords

CARRIER PROTEIN; CHLORIDE; ERYTHROCYTE BAND 3 PROTEIN; STILBENEDISULFONIC ACID;

ACTIVE TRANSPORT; ANIMAL CELL; ANIMAL EXPERIMENT; ANION EXCHANGE; ARTICLE; CELL DISRUPTION; CONTROLLED STUDY; ERYTHROCYTE; HUMAN; HUMAN CELL; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN TRANSPORT; TOAD;

ANIMALS; ANION EXCHANGE PROTEIN 1, ERYTHROCYTE; BICARBONATES; CHLORIDE-BICARBONATE ANTIPORTERS; CHLORINE; DNA, COMPLEMENTARY; ERYTHROCYTES; HUMANS; MICROINJECTIONS; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN CONFORMATION; XENOPUS;

EID: 2342644214     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcmd.2004.01.010     Document Type: Article

References (14)

1. Tanner M.J.A. The structure and function of band 3 (AE1): recent developments. Mol. Membr. Biol. 14:1997;155-165
2. Jennings M.L. Oligomeric structure and the anion transport function of human erythrocyte band 3 protein. J. Membr. Biol. 80:1984;105-117
3. Jennings M.L. Kinetics and mechanism of anion transport in red blood cells. Annu. Rev. Physiol. 47:1985;519-533
4. Passow H. Molecular aspects of band 3 protein-mediated anion transport across the red blood cell membrane. Rev. Physiol. Biochem. Pharmacol. 103:1986;62-223
5. Boron W.F. Sodium-coupled bicarbonate transporters. JOP. 2:2001;176-181
6. - exchangers. J. Nephrol. 15:2002;S41-S53
7. Jennings M.L., Passow H. Anion transport across the erythrocyte membrane, in situ proteolysis of band 3 protein, and cross-linking of proteolytic fragments by 4, 4′-diisothiocyano dihydrostilbene-2, 2′-disulfonate. Biochim. Biophys. Acta. 554:1979;498-519
8. Groves J.D., Wang L., Tanner M.J.A. Functional reassembly of the anion transport domain of human red cell band 3 (AE1) from multiple and non-complementary fragments. FEBS Lett. 433:1998;223-227
9. Groves J.D., Tanner M.J.A. Glycophorin A facilitates the expression of human band 3-mediated anion transport in Xenopus oocytes. J. Biol. Chem. 267:1992;22163-22170
10. Groves J.D., Tanner M.J.A. Structural model for the organization of the transmembrane spans of the human red-cell anion exchanger (band 3; AE1). Biochem. J. 344:1999;699-711
11. Groves J.D., Tanner M.J.A. Topology studies with biosynthetic fragments identify interacting transmembrane regions of the human red-cell anion exchanger (band 3; AE1). Biochem. J. 344:1999;687-697
12. - cotransporter. Nature. 387:1997;409-413
13. Virkki L.V., Franke C., Somieski P., Boron W.F. Cloning and functional characterization of a novel aquaporin from Xenopus laevis oocytes. J. Biol. Chem. 277:2002;40610-40616
14. Fiévet B., Gabillat N., Borgese F., Motais R. Expression of band 3 anion exchanger induces chloride current and taurine transport: structure-function analysis. EMBO J. 14:1995;5158-5169