Enhanced process monitoring of fed-batch penicillin cultivation using time-varying and multivariate statistical analysis

Journal of Biotechnology

Volumn 110, Issue 2, 2004, Pages 119-136

  Lee, Jong Min ^a   Yoo, Chang Kyoo ^b   Lee, In Beum ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

Batch monitoring; Fault detection and identification; Fed batch penicillin cultivation; Multiway principal component analysis (MPCA); Time varying covariance; Variable wise unfolding

Indexed keywords

COMPUTER SIMULATION; CULTIVATION; DRUG PRODUCTS; MONITORING; PRINCIPAL COMPONENT ANALYSIS; STATISTICAL METHODS;

FED-BATCH PROCESSES; ON-LINE MONITORING; PENICILLIN CULTIVATION;

BIOTECHNOLOGY;

PENICILLIN G;

ANALYTIC METHOD; ARTICLE; BATCH PROCESS; DATA ANALYSIS; FED BATCH CULTURE; MOLECULAR DYNAMICS; MULTIVARIATE ANALYSIS; ONLINE ANALYSIS; PRIORITY JOURNAL; PROCESS MONITORING; QUALITY CONTROL; SIMULATION; SPECIES CULTIVATION; STATISTICAL ANALYSIS; TIME;

ALGORITHMS; BIOMASS; BIOREACTORS; COMPUTER SIMULATION; FERMENTATION; MULTIVARIATE ANALYSIS; PENICILLINS; PRINCIPAL COMPONENT ANALYSIS; TIME FACTORS;

EID: 2342642072     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2004.01.016     Document Type: Article

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