Chemo- and stereoselective synthesis of benzocycloheptene and 1-benzoxepin derivatives as α-sympathomimetic and anorexigenic agents

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 11, 2004, Pages 2867-2870

  Tandon, Vishnu K ^a   Singh, Kunwar A ^a   Awasthi, Anoop K ^a   Khanna, J M ^b   Lal, Bansi ^c   Anand, Nitya ^d  

^a UNIVERSITY OF LUCKNOW   (India)

^b Ranbaxy Laboratories   (India)

^c Piramal Enterprises Limited   (India)

^d CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 2,3,4,5 TETRAHYDRO 1 BENZOXEPIN 5 OL; BENZOXEPIN DERIVATIVE; FUSED ALICYCLIC AROMATIC COMPOUND; KETONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CIS ISOMER; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; EXPERIMENTAL MODEL; INTRINSIC SYMPATHOMIMETIC ACTIVITY; LD 50; MOUSE; NONHUMAN; REDUCTION KINETICS; STEREOCHEMISTRY; TRANS ISOMER;

AMPHETAMINES; ANIMALS; APPETITE DEPRESSANTS; BENZOCYCLOHEPTENES; BENZOXEPINS; BLOOD PRESSURE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ANTAGONISM; MICE; OBESITY; STEREOISOMERISM; SYMPATHOMIMETICS;

STAPHYLOCOCCUS PHAGE 3A;

EID: 2342637858     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.03.064     Document Type: Article

References (7)

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4. Hoffmann B.B., Lefkowitz R.J. Goodman, Gilman The Pharmacological Basis of Therapeutics. 9th ed. 1996;232-233 Mc Graw-Hill, U.S.A.
5. Khanna J.M., Bolger J., Anand N. Indian J. Chem. 7:1969;550
6. 2·HCl (215.5): C, 67.03; H, 7.27; N, 7.82. Found: C, 66.70; H, 7.34; N, 7.63
7. 2·HCl (215.5): C, 67.03; H, 7.27; N, 7.82. Found: C, 66.70; H, 7.60; N, 7.54