Synthesis and biological activity of novel platinum(II) complexes of glutamate tethered to hydrophilic hematoporphyrin derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 11, 2004, Pages 2889-2892

  Kim, Yeong Sang ^a,b   Song, Rita ^a   Lee, Chong Ock ^c   Sohn, Youn Soo ^a  

^a Ewha Womans University   (South Korea)

^b Yonsei University   (South Korea)

^c Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

Anticancer drug; Cisplatin; Porphyrin; Tumor targeting

Indexed keywords

CARBOPLATIN; CISPLATIN; ETHYLENE OXIDE; GLUTAMIC ACID; HEMATOPORPHYRIN DERIVATIVE; PLATINUM DERIVATIVE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; COMPLEX FORMATION; CONJUGATE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONJUGATION; DRUG DETERMINATION; DRUG EFFECT; DRUG EFFICACY; DRUG SCREENING; DRUG SYNTHESIS; HYDROPHILICITY; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA CELL; LEUKEMIA L 1210; MOUSE; NONHUMAN; TUMOR LOCALIZATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; GLUTAMIC ACID; HEMATOPORPHYRINS; HYDROPHOBICITY; INHIBITORY CONCENTRATION 50; LEUKEMIA; MICE; ORGANOPLATINUM COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION; TREATMENT OUTCOME;

EID: 2342632047     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.03.038     Document Type: Article

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