Commentary: The 1944 patulin trial: The first properly controlled multicentre trial conducted under the aegis of the British Medical Research Council

International Journal of Epidemiology

Volumn 33, Issue 2, 2004, Pages 253-260

  Chalmers, Iain ^a   Clarke, Mike ^b  

^a James Lind Library   (United Kingdom)

^b UK COCHRANE CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PATULIN; PLACEBO; STREPTOMYCIN;

DISEASE TREATMENT;

ARTICLE; CLINICAL STUDY; CLINICAL TRIAL; COMMON COLD; HUMAN; LUNG TUBERCULOSIS; MEDICAL RESEARCH; OUTCOMES RESEARCH; PRIORITY JOURNAL; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME; UNITED KINGDOM;

COMMON COLD; ENGLAND; GOVERNMENT AGENCIES; HISTORY, 20TH CENTURY; HUMANS; MULTICENTER STUDIES; PATULIN; PENICILLINS; RANDOMIZED CONTROLLED TRIALS;

EID: 2342631333     PISSN: 03005771     EISSN: None     Source Type: Journal    
DOI: 10.1093/ije/dyh162     Document Type: Article

References (35)

1. Boletim 27. Micotoxinas On Line. Accessed at http://www.micotoxinas.com.br/boletim27.htm, 14 January 2004.
2. Letter from Dr Arthur Mortimer, Director of Medical Supplies, Ministry of Supply, to Dr Landsborough Thompson, 5 November 1943. National Archives, FD1/3155.
3. Letter from Dr Landsborough Thompson to Dr Mortimer, 8 November 1943. National Archives, FD1/3155.
4. Raistrick H et al. Patulin in the common cold: collaborative research on a derivative of Penicillin Patulum Banier. Lancet 1943;ii:630-35.
5. Hopkins WA. Patulin in the common cold. IV: Biological properties: extended trial in the common cold. Lancet 1943;ii:631-35.
6. Stuart-Harris CH, Francis AE, Stansfeld JM. Patulin in the common cold. Lancet 1943;ii:684.
7. Stansfeld JM, Francis AE, Stuart-Harris CH. Laboratory and clinical trials of patulin. Lancet 1944;ii:370-72.
8. Medical Research Council. Clinical trial of patulin in the common cold. Lancet 1944;ii:373-75.
9. Birkinshaw JH, Michael SE, Bracken A, Raistrick H. Patulin in the common cold: collaborative research on a derivative of Penicillin patulum Banier. I. Biochemistry and chemistry. Lancet 1943;ii:630-35.
10. Greenwood M. Patulin in the common cold. V: Statistical note. Lancet 1943;ii:634-35.
11. Letter from Dr Landsborough Thompson to Dr Forgan. National Archives, FD1/3155.
12. Letter from Dr Forgan to Dr Landsborough Thompson. National Archives, FD1/3155.
13. Minute 161, MRC Council meeting, 19 November 1943. National Archives, FD1/3154.
14. Minutes of the first meeting of the MRC Patulin Clinical Trials Committee, 25 & 29 Nov 1943. National Archives, FD1/3155.
15. Suggested procedure for Enfield Royal Small Arms Factory pilot trial. Undated. National Archives, FD1/3155.
16. Test to determine whether the proposed patulin solution can with certainty be differentiated by subjects from the control solution. Undated. National Archives, FD1/3155.
17. Broadcast message to employees at the Royal Ordnance Factory, Bishopton, Renfrewshire, 9 March 1944. National Archives, FD1/3157.
18. Letter from Prof CR Harington, National Institute of Medical Research to Dr D'Arcy Hart, 31 May 44. National Archives, FD1/3158.
19. item 109 ('Clinical Trials of Patulin'), minutes of MRC Council meeting, 16 June 1944. National Archives, FD1/3158.
20. Lord President of the Council. Response to Parliamentary Question 51. Hansard Vol 399, No 71, 4 May 1944.
21. Letter from Professor Raistrick to Dr D'Arcy Hart, 23 June 1944. National Archives, FD1/3158.
22. D'Arcy Hart P. Interview with Iain Chalmers, London, 2 May 2003.
23. Letter from Chief Medical Officer, Rolls Royce (Crewe), to Dr D'Arcy Hart, 15 September 1944. National Archives, FD1/3158.
24. Letter from Dr ED Pullinger to Dr D'Arcy Hart, 13 October 1944. National Archives, FD1/3158.
25. Wilkinson L, Hardy A. Prevention and Cure: the London School of Hygiene and Tropical Medicine; a 20th Century Quest for Global Public Health. London: Kegan Paul, 2001, pp. 181-83.
26. D'Arcy Hart P. Interview with Iain Chalmers and Mike Clarke, London, 17 Jan 2000.
27. Letter from Dr Clayton-Jones to Dr D'Arcy Hart, 20 July 1944. National Archives, FD1/3158.
28. British Medical Journal. The end of patulin. BMJ 1944;ii:603.
29. Letter from Dr Mortimer to Dr Landsborough Thomson, 10 November 1943. National Archives, FD1/3155.
30. Letter from Prof Ronald Christie to Professor Harold Himsworth, 28 June 1955. National Archives, FD1/3158.
31. D'Arcy Hart P. Early controlled clinical trials. BMJ 1996;312:378-79.
32. Chalmers I. Statistical theory was not the reason that randomisation was used in the British Medical Research Council's clinical trial of streptomycin for pulmonary tuberculosis. In: Weisz G, Jorland G, Opinel A (eds). Quantification in the Medical and Health Sciences in Historical and Sociological Perspective. Montreal: McGill-Queens University Press. (In press.)
33. Landsborough Thomson A. Half a Century of Medical Research. London: HMSO, 1975, Vols 1 & 2.
34. Chalmers I. MRC Therapeutic Trials Committee's report on serum treatment of lobar pneumonia, BMJ 1934. In: The James Lind Library (www.jameslindlibrary.org). Accessed Monday 2 February 2004.
35. Letter from Dr D'Arcy Hart to Dr Morland, Editor of the Lancet, 29 June 1944. National Archives, FD1/3158.