Antitumor effects of the immunoconjugate composed of lidamycin and monoclonal antibody 3 G11

Yaoxue Xuebao

Volumn 38, Issue 7, 2003, Pages 515-519

  Wang, Feng Qiang ^a   Shang, Bo Yang ^a   Zhen, Yong Su ^a  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

Author keywords

Immunoconjugate; Lidamycin; Monoclonal antibody; Type IV collagenase

Indexed keywords

AMINOGLYCOSIDE; ANTIBIOTIC C 1027; ANTIBODY CONJUGATE; ANTINEOPLASTIC ANTIBIOTIC; ENEDIYNE; GELATINASE A; GELATINASE B; MONOCLONAL ANTIBODY;

ANIMAL; ARTICLE; CANCER TRANSPLANTATION; CELL CULTURE; CELL DIVISION; DISEASE MODEL; DRUG EFFECT; FEMALE; IMMUNOLOGY; LIVER TUMOR; MOUSE; PATHOLOGY; RANDOMIZATION;

AMINOGLYCOSIDES; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIBODIES, MONOCLONAL; CELL DIVISION; DISEASE MODELS, ANIMAL; ENEDIYNES; FEMALE; IMMUNOCONJUGATES; LIVER NEOPLASMS, EXPERIMENTAL; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; NEOPLASM TRANSPLANTATION; RANDOM ALLOCATION; TUMOR CELLS, CULTURED;

EID: 2342628682     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Zhen YS. Advances in research on monoclonal antibody agents for cancer therapy [J]. Acta Acad Med Sin, 2000, 22(1):9-13.
2. Bross PF, Beitz J, Chen G, et al. Approval summary: gemtuzumab ozogamicin in relapsed acute myeloid leukemia [J]. Clin Cancer Res, 2001,7(6): 1490-1496.
3. Gordon LI, Witzig TE, Wiseman GA, et al. Yttrium 90 ibritumomab tiuxetan radioimmunotherapy for relapsed or refractory low-grade non-Hodgkin's lymphoma [J]. Semin Oncol, 2002, 29 (1 Suppl 2): 87-92.
4. Nelson AR, Fingleton B, Rothenberg ML, et al. Matrix metalloproteinases: biologic activity and clinical implications [J]. J Clin Oncol, 2000, 18(5): 1135-1149.
5. Mc Cawley LJ, Matrisian LM. Matrix metalloproteinases: multifunctional contributors to tumor progression [J]. Mol Med Today, 2000, 6(4): 149-156.
6. Liu XY, Zhen YS. Antitumor effects of monoclonal antybody Fab' fragment-containing immunoconjugates [J]. Chin Med Sci, 2002, 17(1):1-6.
7. Tang Y, Zhen YS. Expression of anti-type IV collagenase scFv fragment and inhibition of tumor cell invasion [J]. Chin J Cancer, 2001, 20(8):801-805.
8. Xu YJ, Li DD, Zhen YS. Mode of action of C-1027, a new macromolecular antitumor antibiotic with highly potent cytotoxicity, on human BEL-7402 cells [J]. Cancer Chemother Pharmacol, 1990, 27(1): 41-46.
9. Xu YJ, Zhen YS, Goldberg IH. C1027 chromophore, a potent new enediyne antitumor antibiotic, induces sequence-specific double-strand DNA cleavage [J]. Biochemistry, 1994, 33(19):5947-5954.
10. Zhen HY, Xue YC, Zhen YS. Anti-angiogenic and antimetastatic activity of an antitumor antibiotics-C1027 [J]. Natl Med J China, 1997, 77(9):657-660.