Reduced bone mineral density and increased bone turnover in Prader-Willi syndrome compared with controls matched for sex and body mass index - A cross-sectional study

Journal of Pediatrics

Volumn 144, Issue 5, 2004, Pages 614-619

  Vestergaard, Peter ^a   Kristensen, Kurt ^b   Bruun, Jens M ^b   Østergaard, John R ^b   Heickendorff, Lene ^b   Mosekilde, Leif ^b   Richelsen, Bjørn ^b  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; AMINO TERMINAL TELOPEPTIDE; BIOCHEMICAL MARKER; CARBOXY TERMINAL TELOPEPTIDE; COLLAGEN TYPE 1; FAT; OSTEOCALCIN; PROTEIN DERIVATIVE;

ADOLESCENT; ADULT; ARTICLE; BODY MASS; BONE DENSITY; BONE MINERAL; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS LINKING; ENZYME BLOOD LEVEL; FEMALE; HEMOCONCENTRATION; HUMAN; INTERMETHOD COMPARISON; LEAN BODY WEIGHT; MALE; MEASUREMENT; OSTEOLYSIS; PATIENT SELECTION; POPULATION RESEARCH; PRADER WILLI SYNDROME; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZATION; STATISTICAL SIGNIFICANCE; TESTOSTERONE BLOOD LEVEL;

EID: 2342612189     PISSN: 00223476     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpeds.2004.01.056     Document Type: Article

References (24)

1. Cassidy SB. Prader-Willi syndrome. J Med Genet 1997;34:917-23.
2. Hauffa BP. One-year results of growth hormone treatment of short stature in Prader-Willi syndrome. Acta Paediatr Suppl 1997;423:63-5.
3. Fieldstone A, Zipf WB, Schwartz HC, Berntson GG. Food preferences in Prader-Willi syndrome, normal weight and obese controls. Int J Obes Relat Metab Disord 1997;21:1046-52.
4. Brambilla P, Bosio L, Manzoni P, Pietrobelli A, Beccaria L, Chiumello G. Peculiar body composition in patients with Prader-Labhart-Willi syndrome. Am J Clin Nutr 1997;65:1369-74.
5. Butler MG, Haber L, Mernaugh R, Carlson MG, Price R, Feurer ID. Decreased bone mineral density in Prader-Willi syndrome: comparison with obese subjects. Am J Med Genet 2001;103:216-22.
6. Ribot C, Tremollieres F, Pouilles J-M, Bonneu M, Germain F, Louvet J-P. Obesity and postmenopausal bone loss: the influence of obesity on vertebral density and bone turnover in postmenopausal women. Bone 1988;8:327-31.
7. Carrel AL, Myers SE, Whitman BY, Allen DB. Growth hormone improves body composition, fat utilization, physical strength and agility, and growth in Prader-Willi syndrome: a controlled study. J Pediatr 1999;134:215-21.
8. Johannsson G, Bengtsson BA. Growth hormone and the acquisition of bone mass. Horm Res 1997;48(Suppl 5):72-7.
9. Bosio L, Beccaria L, Benzi F, Sanzari A, Chiumello G. Body composition during GH treatment in Prader-Labhardt-Willi syndrome. J Pediatr Endocrinol Metab 1999;12(Suppl 1):351-3.
10. Cinaz P, Hasanoglu E, Gokcora N, Dogukan S, Demir A. Serum levels of carboxyterminal propeptide of type I procollagen and aminoterminal propeptide of type in procollagen in children with growth retardation. Matern Med Pol 1994;26:55-8.
11. Greendale GA, Edelstein S, Barrett-Connor E. Endogenous sex steroids and bone mineral density in older women and men: the Rancho Bernardo Study. J Bone Miner Res 1997;12:1833-43.
12. Ebeling PR, Peterson JM, Riggs BL. Utility of type I procollagen propeptide assays for assessing abnormalities in metabolic bone disease. J Bone Miner Res 1992;7:1243-50.
13. Brixen K, Nielsen HK, Eriksen EF, Charles P, Mosekilde L. Efficacy of wheat germ lectin-precipitated alkaline phosphatase in serum as an estimator of bone mineralization rate: comparison to serum alkaline phosphatase and serum bone Gla-protein. Calcif Tissue Int 1989; 44:93-8.
14. Delmas PD, Schlemmer A, Gineyts E, Riis B, Christiansen C. Urinary excretion of pyridinoline crosslinks correlates with bone turnover measured on iliac crest biopsy in patients with vertebral osteoporosis. J Bone Miner Res 1991;6:639-44.
15. Risteli J, Niemi S, Trivedi P, Maentausta O, Mowat AP, Risteli L. Rapid equilibrium radioimmunoassay for the amino-terminal propeptide of human type m procollagen. Clin Chem 1988;34:715-8.
16. Vestergaard P, Hermann AP, Ørskov H, Mosekilde L. Efiect of sex hormone replacement on the insulin-like growth factor system and bone mineral: a cross-sectional and longitudinal study in 595 perimenopausal women participating in the Danish Osteoporosis Prevention Study. J Clin Endocrinol Metab 1999;84:2286-90.
17. Rosenquist C, Qvist P, Bjarnason N, Christiansen C. Measurement of a more stable region of osteocalcin in serum by ELISA with two monoclonal antibodies. Clin Chem 1995;41:1439-45.
18. Garnero P, Borel O, Delmas PD. Evaluation of a fully automated serum assay for C-terminal cross-linking telopeptide of type I collagen in osteoporosis. Clin Chem 2001;47:694-702.
19. Hanson DA, Weis MAE, Bollen A-M, Maslan SL, Singer FR, Eyre DR. A specific immunoassay for monitoring human bone resorption: quantitation of type I collagen cross-linked N-telopeptides in urine. J Bone Miner Res 1992;7:1251-8.
20. Melkko J, Kauppila S, Niemi S, Risteli L, Haukipuro K, Jukkola A, et al. Immunoassay for intact amino-terminal propeptide of human type I procollagen. Clin Chem 1996;42:947-54.
21. Eiholzer U, Weber R, Stutz K, Steinert H. Effect of 6 months of growth hormone treatment in young children with Prader-Willi syndrome. Acta Paediatr Suppl 1997;423:66-8.
22. Toogood AA, Adams JE, O'Neill PA, Shalet SM. Elderly patients with adult-onset growth hormone deficiency are not osteopenic. J Clin Endocrinol Metab 1997;82:1462-6.
23. Degerblad M, Bengtsson BA, Bramnert M, Johnell O, Manhem P, Rosen T, et al. Reduced bone mineral density in adults with growth hormone (GH) deficiency: increased bone turnover during 12 months of GH substitution therapy. Eur J Endocrinol 1995;133:180-8.
24. Christiansen C, Riis BJ. 17β-estradiol and continuous norethisterone: a unique treatment for established osteoporosis in elderly women. J Clin Endocrinol Metab 1990;71:836-41.