Chloramphenicol succinate, a competitive substrate and inhibitor of succinate dehydrogenase: Possible reason for its toxicity

Toxicology in Vitro

Volumn 18, Issue 4, 2004, Pages 441-447

  Ambekar, C S ^a   Lee, J S K ^a   Cheung, B M Y ^a   Chan, L C ^a   Liang, R ^a   Kumana, C R ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Chloramphenicol succinate; Human bone marrow and liver; Metabolism; Rat liver and kidney mitochondria; Succinate dehydrogenase

Indexed keywords

CHLORAMPHENICOL HEMISUCCINATE; MALONIC ACID; SUCCINATE DEHYDROGENASE;

ANIMAL CELL; ARTICLE; BONE MARROW; BONE MARROW TOXICITY; COMPETITIVE INHIBITION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME METABOLISM; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY PARENCHYMA; LIVER; LIVER MITOCHONDRION; LIVER TOXICITY; MALE; METABOLITE; NEPHROTOXICITY; NONHUMAN; RAT; REDUCTION; TOXICOKINETICS;

ANIMALS; BONE MARROW; CHLORAMPHENICOL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; KIDNEY; LIVER; MITOCHONDRIA; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTEIN SYNTHESIS INHIBITORS; RATS; SUCCINATE DEHYDROGENASE;

ANIMALIA;

EID: 2342593351     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2003.12.010     Document Type: Article

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