Ultrastructure of Clara cells stimulated by isoproterenol

Journal of Medical and Dental Sciences

Volumn 50, Issue 3, 2003, Pages 195-202

  Aryal, Gopi ^a   Kimula, Yuji ^b   Koike, Morio ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b Ohme Municipal General Hospital   (Japan)

Author keywords

Beta antagonist; Clara cell; Isoproterenol; Lung adenocarcinoma

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; ISOPRENALINE; LUNG SURFACTANT; PROPRANOLOL;

ANIMAL; ARTICLE; BRONCHUS; C57BL MOUSE; CELL SIZE; CYTOPLASM; DRUG EFFECT; ELECTRON MICROSCOPY; EPITHELIUM CELL; MALE; METABOLISM; MOUSE; MOUSE STRAIN; SCANNING ELECTRON MICROSCOPY; SECRETORY VESICLE; TIME; ULTRASTRUCTURE;

ADRENERGIC BETA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; BRONCHI; CELL SIZE; CYTOPLASM; EPITHELIAL CELLS; ISOPROTERENOL; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICROSCOPY, ELECTRON; MICROSCOPY, ELECTRON, SCANNING; PROPRANOLOL; PULMONARY SURFACTANTS; SECRETORY VESICLES; TIME FACTORS;

EID: 2342593300     PISSN: 13428810     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Plopper CG, Hyde DM, Buckpitt AR: Clara cells. In The lung: Scientific Foundation. RG Crystal and JB West, editors. Raven Press, Newyork, 1991,215-228.
2. Plopper CG, Cranz DL, Kemp L, et al: Immunohistochemical demonstration of cytochrome p-450 monooxygenase in Clara cells throught the tracheobronchial airways of the rabbit. Exp.Lung Res 1987;13:59-68.
3. Devereux TR, Domin BA, Philpot RM: Xenobiotic metabolism by isolated pulmonary cells. Pharmacol Ther 1989;41:243-256.
4. Kimula Y: A histochemical and ultrastructural study of adenocarcinoma of the lung. Am J Surg Pathol 1978;2:253-264.
5. Ogata T, Endo K: Clara cell granules of peripheral lung cancers: Cancer 1984;54:1635-1644.
6. Niden AH: Bronchiolar and large alveolar cell in pulmonary phospholipid metabolism. Science 1967;158:1323-1324.
7. Kikkawa Y, Yoneda K, Smith F, et al: The type II epithelial cells of the lung. II. Chemical composition and phospholipid synthesis. Lab Invest 1975;32:295-302
8. Nijkamp FP: β-adrenergic receptors in the lung: An introduction. Life Sciences 1993;52:2073-2082.
9. Koelliker A: Zur Kenntnis des Baues der Lunge des Menschen: Verh physik Med Ges Wuerzburg 1881;16:1-24.
10. Clara M: Zur Histobiologie des Bronchialepithels. Z. Mikrosk.Anat. Forsch 1937;41:321-347.
11. Hung KS, Chapman AL, Hung SH, Menon CD: Clara cell surface of the rat: scanning and transmission electron microscopic study. Experientia 1982;38:959-961.
12. Smith P, Heath D, Moosavi H: The Clara cell. Thorax 1974;29:147-163.
13. Yoneda K: Pilocarpine stimulation of the bronchiolar Clara cell secretion. Lab Invest 1977;37:447-452.
14. Stinson SF, Loosli CG: Ultrastructural evidence concerning the mode of secretion of electron-dense granules by Clara cells. J Anat 1978;127:291-298.
15. Peao MN, Aguas AP, de Sa CM, Grande NR: Anatomy of Clara cell secretion: surface changes observed by scanning electron microscopy. J Anat 1993;182: 377-388.
16. Massaro GD, Paris M, Thet LA: In vivo regulation of secretion of bronchiolar Clara cells in rats. J Clin Invest 1979;63:167-172.
17. Massaro GD, Fischman CM, Chiang MJ, et al: Regulation of Secretion in Clara cells: studies using the isolated perfused rat lung. J Clin Invest 1981;67:345-351.
18. Goldenthal EI: A compilation of LD50 values in newborn and adult animals. Toxicol Appl Pharmacol 1971;18:185-207.
19. Martin M, Linee P: Toxicity data. Eur. J. Med.Chem;1974;9:563.
20. Reid L, Jones R: Bronchial mucosal cells. Fed Proc 1979;38:191-196.
21. Carstairs JR, Nimmo AJ, Barnes PJ: Autoradiographic visualization of beta-adrenoceptors subtype in human lung. Am Rev Respir Dis 1985;132:541-547.
22. Davis PB, Silski CL, Kercomar P, Infeld M: Beta-adrenergic receptors on human tracheal epithelial cells in primary culture. Am J Physiol 1990;258:C71-C76.
23. Schuller HM and Cole B: Regulation of cell proliferation by beta-adrenergic receptors in a human lung adenocarcinoma cell line. Carcinogenesis 1989;10:1753-1755.
24. Schramm M: Secretion of enzymes and other macromolecules. Ann. Rev. Biochemn 1967,36:307-320.
25. Palade G: Intracellular aspects of the process of protein synthesis. Science (Wash. D.C) 1975;189:347-358.
26. Cutz E, Conen PE: Ultrastructure and cytochemistry of Clara cells. Am J Pathol 1971;62:127-141.
27. Van Scott MR, Hester S, Boucher RC: Ion transport by rabbit nonciliated bronchiolar epithelial cells (Clara cells) in culture. Proc Natl Acad Sci U S A 1987;84:5496-5500.
28. Kuhn III C, Callaway LA, Askin FB: The formation of granules in the bronchiolar Clara cells of the rat. I. Electron microscopy. J Ultrastruct Res 1974;49:387-400.
29. 3H-galactose in non-ciliated bronchiolar (Clara) cells of mice. Am J Anat 1974;139:519-534.
30. Yoneda K: Ultrastructural localization of phospholipases in the Clara cell of the rat. Bronchiole.Am J Pathol 1978;93:745-752.
31. Cakir Y, Plummer III H, Tithof PK, Schuller HM: Beta-adrenergic and arachidonic acid-mediated growth regulation of human breast cancer cell lines. Int J Oncol 2002;21:153-157.
32. Weddle DL, Tithoff P, Williams M, Schuller HM: Beta-adrenergic growth regulation of human cancer cell lines derived from pancreatic ductal carcinomas. Carcinogenesis 2001;22:473-479.
33. Park PG, Merryman J, Orloff M, Schuller HM: Beta-adrenergic mitogenic signal transduction in peripheral lung adenocarcinoma: implications for individuals with preexisting chronic lung disease. Cancer Res 1995;55:3504-3508.
34. Masubuchi Y, Hosokawa S, Horie T et al. Cytochrome p450 isozymes involved in propranolol metabolism in human liver microsomes. The role of CYP2D6 as ring-hydroxylase and CYP1A2 as N-desisopropylase. Drug Metab Dispos 1994;22:909-915.