The effect of oral 5-HTP administration on 5-HTP and 5-HT immunoreactivity in monoaminergic brain regions of rats

Journal of Chemical Neuroanatomy

Volumn 27, Issue 2, 2004, Pages 129-138

  Lynn Bullock, Christina P ^a   Welshhans, Kristy ^a   Pallas, Sarah L ^a   Katz, Paul S ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

Author keywords

5 Hydroxytryptophan; Co localization; Confocal fluorescence microscopy; Double label immunohistochemistry; HPLC; Serotonin

Indexed keywords

5 HYDROXYTRYPTOPHAN; AMINO ACID DECARBOXYLASE; SEROTONIN; SEROTONIN 1 AGONIST;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DORSAL RAPHE NUCLEUS; DRUG EFFECT; DRUG PROTEIN BINDING; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOREACTIVITY; LOCUS CERULEUS; METABOLITE; MONOAMINERGIC SYSTEM; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SEROTONINERGIC NERVE CELL; SEROTONINERGIC SYSTEM; SUBSTANTIA NIGRA; TISSUE DISTRIBUTION; URINE LEVEL;

5-HYDROXYTRYPTOPHAN; ADMINISTRATION, ORAL; ANIMALS; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROXYINDOLEACETIC ACID; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAPERITONEAL; MICROSCOPY, CONFOCAL; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN;

EID: 2342567838     PISSN: 08910618     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchemneu.2004.02.003     Document Type: Article

References (31)

1. Arai R., Horiike K., Hasegawa Y. Dopamine-degrading activity of monoamine oxidase is not detected by histochemistry in neurons of the substantia nigra pars compacta of the rat. Brain Res. 812:1998;275-278
2. Arai R., Karasawa N., Geffard M., Nagatsu T., Nagatsu I. Immunohistochemical evidence that central serotonin neurons produce dopamine from exogenous L-DOPA in the rat, with reference to the involvement of aromatic L-amino acid decarboxylase. Brain Res. 667:1994;295-299
3. Arai R., Karasawa N., Nagatsu T., Nagatsu I. Exogenous L-5-hydroxytryptophan is decarboxylated in neurons of the substantia nigra par compacta and locus coeruleus of the rat. Brain Res. 669:1995;145-149
4. Boadle-Biber, M.C., 1982. Biosynthesis of serotonin. In: Osborne, N.N. (Ed.), Biology of Serotonergic Transmission. Wiley, Chichester, pp. 63-94.
5. Bogdanski D.F., Wissbach H., Udenfriend S. Pharmacological studies with the serotonin precursor, 5-hydroxytryptophan. J. Pharmacol. Exp. Ther. 122:1958;182-194
6. Bouchaud C. Demonstration par radioautographie de l'existence d'une barriere hematoencephalique pour la 5-hydroxytryptamine. C.R. Acad. Sci. Hebd. Seances Acad. Sci. D. 275:1972;975-978
7. Brownfield M.S., Yracheta J., Chu F., Lorenz D., Diaz A. Functional chemical neuroanatomy of serotonergic neurons and their targets: antibody production and immunohistochemistry (IHC) for 5-HT, its precursor (5-HTP) and metabolite (5-HIAA), biosynthetic enzyme (TPH), transporter (SERT), and three receptors (5-HT2A, 5-HT5a, 5-HT7). Proc. Natl. Acad. Sci. 861:1998;232-233
8. Byerley W.F., Risch S.C. Depression and serotonin metabolism: rationale for neurotransmitter precursor treatment. J. Clin. Psychopharm. 5:1985;191-206
9. Chase T.N. 5-Hydroxytryptophan in Parkinsonism. Lancet. 2:1970;1029-1030
10. Denoyer M., Kitahama K., Sallanon M., Touret M., Jouvet M. 5-Hydroxytryptophan uptake and decarboxylating neurons in the cat hypothalamus. Neuroscience. 31:1989;203-211
11. Fickbohm D.J., Katz P.S. 5-HT content alters the modulatory actions of serotonergic neurons in the Tritonia swim CPG. Soc. Neurosci. Abstr. 25:1999;168
12. Fickbohm D.J., Lynn-Bullock C.P., Spitzer N., Katz P.S. Localization and quantification of 5-hydroxytryptophan and serotonin in the central nervous systems of Tritonia and Aplysia. J. Comp. Neurol. 437:2001;91-105
13. Geffard M., Touret M., Kitahama K. First characterization of 5-hydroxytryptophan in rat brain by using specific antibodies. Brain Res. 426:1987;191-196
14. Hashimoto S., Inoue T., Koyama T. Effects of conditioned fear stress on serotonin neurotransmission and freezing behavior in rats. Eur. J. Pharm. 378:1999;23-30
15. Hirai M., Nakajima T. Biochemical studies on the mechanism of difference in the renal toxicity of 5-hydroxy-L-tryptophan between Sprague Dawley and Wistar rats. J. Biochem. (Tokyo). 86:1979;907-913
16. Imeri L., Mancia M., Bianchi S., Opp M.R. 5-Hydroxytryptophan, but not L-tryptophan, alters sleep and brain temperature in rats. Neuroscience. 95:2000;445-452
17. Jesberger J.S. Neurochemical aspects of depression: the past and the future. Int. J. Neurosci. 27:1985;19-47
18. Kitahama K., Ikemoto K., Jouvet A., Nagatsu I., Sakamoto N., Pearson J. Aromatic L-amino acid decarboxylase- and tyrosine hydroxylase- immunohistochemistry in the adult human hypothalamus. J. Chem. Neuroanat. 16:1998;43-55
19. Kitahama K., Jouvet A., Fujimiya M., Nagatsu I., Arai R. 5-Hydroxytryptophan (5-HTP) uptake and decarboxylation in the kitten brain. J. Neural. Transm. 109:2002;683-689
20. Klein P., Lees A., Stern G. Consequences of chronic 5-hydroxytryptophan in Parkinsonian instability of gait and balance and in other neurological disorders. Adv. Neurol. 45:1986;603-604
21. Lynn-Bullock C.P., Welshhans K., Reedy A., Belinga S.F., Pallas S.L., Katz P.S. 5-HTP- and 5-HT-immunoreactivity in the raphe nucleus, substantia nigra, and locus coeruleus after oral 5-HTP administration. Soc. Neurosci. Abstr. 27:2001;414
22. Murray, M., 1998. 5-HTP: the Natural Way to Overcome Depression, Obesity and Insomnia. Bantam Books, New York.
23. Sahelian, R., 1998. 5-HTP: Nature's Serotonin Solution. Avery Publishing Group, New York.
24. Sloley B.D., Juorio A.V. Monoamine neurotransmitters in invertebrates and vertebrates: an examination of the diverse enzymatic pathways utilized to synthesize and inactivate biogenic amines. Int. Rev. Neurobiol. 38:1995;253-303
25. Stamford J.A., Kruk Z.L., Millar J. Striatal dopamine terminals release serotonin after 5-HTP pretreatment: in vivo voltammetric data. Brain Res. 515:1990;173-180
26. Stier C.T., Itskovitz H.D. Formation of serotonin by rat kidneys in vivo. Proc. Soc. Exp. Biol. Med. 180:1985;550-557
27. Touret M., Kitahama K., Geffard M., Jouvet M. 5-Hydroxytryptophan (5-HTP)-immunoreactive neurons in the rat brain tissue. Neurosci. Lett. 80:1987;263-267
28. Vanhatalo S., Soinila S. Release of false transmitter serotonin from the dopaminergic nerve terminals of the rat pituitary intermediate lobe. Neurosci. Res. 22:1995;367-374
29. Wyatt R.J., Zarcone V., Engelman K., Dement W.C., Snyder F., Sjoerdsma A. Effects of 5-hydroxytrytophan on the sleep of normal human subjects. Electroencephalogr. Clin. Neurophysiol. 30:1971;505-509
30. Zhou F.C., Lesch K.-P., Murphy D.L. Serotonin uptake into dopamine neurons via dopamine transporters: a compensatory alternative. Brain Res. 942:2002;109-119
31. Zhu M.Y., Juorio A.V. Aromatic L-amino acid decarboxylase: biological characterization and functional role. Gen. Pharmacol. 26:1995;681-696