Design and syntheses of 4-[3-(1-methoxycarbonyl-1,6-dihydropyridyl)]- and 4-[3-(1-methoxycarbonyl-4-substituted-1,4-dihydropyridyl)]- derivatives of alkyl 1,4-dihydro-2,6-dimethyl-3-nitro-5-pyridinecarboxylates with calcium channel modulating activities

Arkivoc

Volumn 2001, Issue 6, 2001, Pages 42-62

  Amini, Mohsen ^a   McEwen, Carol Anne ^a   Knaus, Edward E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Calcium channel modulation; Dihydropyridines; Drug design concepts; Positive inotropic agents; Regiochemistry

Indexed keywords

1 METHOXYCARBONYL 4 METHYL 1,4 DIHYDROPYRIDINE 3 CARBOXALDEHYDE; 1 METHOXYCARBONYL 4 PHENYL 1,4 DIHYDROPYRIDINE 3 CARBOXALDEHYDE; 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 [3 (1 METHOXYCARBONYL 4 METHYL 1,4 DIHYDROPYRIDYL)] 5 PYRIDINECARBOXYLATE; 4 BUTYL 1 METHOXYCARBONYL 1,4 DIHYDROPYRIDINE 3 CARBOXALDEHYDE; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL STIMULATING AGENT; DIHYDROPYRIDINE DERIVATIVE; ETHYL 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 [3 (1 METHOXYCARBONYL 1,6 DIHYDROPYRIDYL)] 5 PYRIDINECARBOXYLATE; ETHYL 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 [3 (1 METHOXYCARBONYL 4 BUTYL 1,4 DIHYDROPYRIDYL)] 5 PYRIDINECARBOXYLATE; ETHYL 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 [3 (1 METHOXYCARBONYL 4 PHENYL 1,4 DIHYDROPYRIDYL)] 5 PYRIDINECARBOXYLATE; ISOBUTYL 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 [3 (1 METHOXYCARBONYL 1,6 DIHYDROPYRIDYL)] 5 PYRIDINECARBOXYLATE; ISOBUTYL 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 [3 (1 METHOXYCARBONYL 4 BUTYL 1,4 DIHYDROPYRIDYL)] 5 PYRIDINECARBOXYLATE; ISOBUTYL 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 [3 (1 METHOXYCARBONYL 4 METHYL 1,4 DIHYDROPYRIDYL)] 5 PYRIDINECARBOXYLATE; ISOBUTYL 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 [3 (2 METHOXYCARBONYL 4 PHENYL 1,4 DIHYDROPYRIDYL)] 5 PYRIDINECARBOXYLATE; ISOPROPYL 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 [3 (1 METHOXYCARBONYL 1,6 DIHYDROPYRIDYL)] 5 PYRIDINECARBOXYLATE; ISOPROPYL 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 [3 (1 METHOXYCARBONYL 4 BUTYL 1,4 DIHYDROPYRIDYL)] 5 PYRIDINECARBOXYLATE; ISOPROPYL 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 [3 (1 METHOXYCARBONYL 4 METHYL 1,4 DIHYROPYRIDYL)] 5 PYRIDINECARBOXYLATE; ISOPROPYL 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 [3 (1 METHOXYCARBONYL 4 PHENYL 1,4 DIHYDROPYRIDYL)] 5 PYRIDINECARBOXYLATE; METHYL 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 [3 (1 METHOXYCARBONYL 1,6 DIHYDROPYRIDYL)] 5 PYRIDINECARBOXYLATE; METHYL 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 [3 (1 METHOXYCARBONYL 4 BUTYL 1,4 DIHYDROPYRIDYL)] 5 PYRIDINECARBOXYLATE; METHYL 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 [3 (1 METHOXYCARBONYL 4 METHYL 1,4 DIHYDROPYRIDYL)] 5 PYRIDINECARBOXYLATE; METHYL 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 [3 (1 METHOXYCARBONYL 4 PHENYL 1,4 DIHYDROPYRIDYL)] 5 PYRIDINECARBOXYLATE; TERT BUTYL 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 [3 (1 METHOXYCARBONYL 1,6 DIHYDROPYRIDYL)] 5 PYRIDINECARBOXYLATE; TERT BUTYL 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 [3 (1 METHOXYCARBONYL 4 BUTYL 1,4 DIHYDROPYRIDYL)] 5 PYRIDINECARBOXYLATE; TERT BUTYL 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 [3 (1 METHOXYCARBONYL 4 METHYL 1,4 DIHYDROPYRIDYL)] 5 PYRIDINECARBOXYLATE; TERT BUTYL 1,4 DIHYDRO 2,6 DIMETHYL 3 NITRO 4 [3 (1 METHOXYCARBONYL 4 PHENYL 1,4 DIHYDROPYRIDYL)] 5 PYRIDINECARBOXYLATE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL MODIFICATION; CHEMICAL REACTION; CONGESTIVE HEART FAILURE; DRUG ACTIVITY; DRUG DESIGN; DRUG EFFECT; DRUG INDICATION; DRUG MECHANISM; DRUG STRUCTURE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 2342563273     PISSN: 14246376     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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