Association of the mitochondrial DNA 16189 T to C variant with lacunar cerebral infarction: Evidence from a hospital-based case-control study

Annals of the New York Academy of Sciences

Volumn 1011, Issue , 2004, Pages 317-324

  Liou, Chia Wei ^a   Lin, Tsu Kung ^a   Huang, Feng Mei ^a   Chen, Tzu Ling ^b   Lee, Cheng Feng ^b   Chuang, Yao Chung ^a   Tan, Teng Yeow ^a   Chang, Ku Chou ^a   Wei, Yau Huei ^b  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Insulin resistance; Lacunar cerebral infarction; Mitochondrial DNA; T16189C polymorphism

Indexed keywords

ADULT; AGED; BRAIN INFARCTION; CLINICAL FEATURE; CONFERENCE PAPER; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC ANALYSIS; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; STATISTICAL ANALYSIS;

EID: 2342559068     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1293.031     Document Type: Conference Paper

References (32)

1. UEDA, K., T. OMAE, Y. HIROTA, et al. 1981. Decreasing trend in incidence and mortality from stroke in Hisayama residents, Japan. Stroke 12: 154-160.
2. TUOMILEHTO, J., R. BONITA, A. STEWART, et al. 1991. Hypertension, cigarette smoking, and the decline in stroke incidence in eastern Finland. Stroke 22: 7-11.
3. BROWN, R.D., J.P. WHISNANT, J.D. SICKS, et al. 1996. Stroke incidence, prevalence and survival: secular trends in Rochester, Minnesota, through 1989. Stroke 27: 373-380.
4. WOLF, P.A., R.B. D'AGOSTINO, M.A. O'NEAL, et al. 1992. Secular trends in stroke incidence and mortality. The Framingham Study. Stroke 23: 1551-1555.
5. GILLUM, R.F. & C.T. SEMPOS. 1997. The end of the long-term decline in stroke mortality in the United States? Stroke 28: 1527-1529.
6. KERNAN, W.N., S.E. INZUCCHI, C.M. VISCOLI, et al. 2002. Insulin resistance and risk for stroke. Neurology 59: 809-815.
7. MATHER, K., T.J. ANDERSON & S. VERMA. 2001. Insulin action in the vasculature: physiology and pathophysiology. J. Vasc. Res. 38: 415-422.
8. HU, R.M., E.R. LEVIN, A. PEDRAM & H.J.L. FRANK. 1993. Insulin stimulates production and secretion of endothelin from bovine endothelial cells. Diabetes 42: 351-358.
9. SCHERRER, U., D. RANDIN, P. VOLLENWEIDER, et al. 1994. Nitric oxide release accounts for insulin's vascular effects in humans. J. Clin. Invest. 94: 2511-2515.
10. st edit. G.M Reaven & A. Lews, Eds.: 247-260. Humana Press. Totowa, NJ.
11. KAY, R., J. WOO, L. KREEL, et al. 1992. Stroke subtypes among Chinese living in Hong Kong: the Shatin Stroke Registry. Neurology 42: 985-987.
12. YIP, P.K., J.S. JENG, T.K. LEE, et al. 1997. Subtypes of ischemic stroke: a hospital-based stroke registry in Taiwan (SCAN-IV). Stroke 28: 2507-2512.
13. TANIZAKI, Y., Y. KIYOHARA, I. KATO, et al. 2000. Incidence and risk factors for subtypes of cerebral infarction in a general population: the Hisayama study. Stroke 31: 2616-2622.
14. LIOU, C.W., P.W. WANG, T.L. CHEN, et al. 2002. The relationship of mitochondrial DNA 16189 polymorphism to the pathogenesis of type 2 diabetes mellitus complicated by cerebral infarction. 4th Symposium on Molecular Diabetology in Asia, Abstr. A42. Shanghai.
15. HORAI, S. & K. HAYASAKA. 1990. Intraspecific nucleotide sequence differences in the major noncoding region of human mitochondrial DNA. Am. J. Hum. Genet. 46: 828-842.
16. JI, L., L. GAO & X. HAN. 2001. Association of 16189 variant (T→C transition) of mitochondrial DNA with genetic predisposition to type 2 diabetes in Chinese populations. Zhonghua Yi Xue Za Zhi 81: 711-714.
17. KIM, J.H., K.S. PARK, Y.M. CHO, et al. 2002. The prevalence of the mitochondrial DNA 16189 variant in non-diabetic Korean adults and its association with higher fasting glucose and body mass index. Diabet. Med. 19: 681-684.
18. ADAMS, H.P., B.H. BENDIXEN, L.J. KAPPELLE, et al. 1993. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. Stroke 24: 35-41.
19. SHIH, K.D., T.C. YEN, C.Y. PANG & Y.H. WEI. 1991. Mitochondrial DNA mutation in a Chinese family with myoclonic epilepsy and ragged-red fiber disease (MERRF). Biochem. Biophys. Res. Commun. 174: 1109-1116.
20. MATTHEWS, D.R., J.P. HOSKER, A.S. RUDENSKI, et al. 1985. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419.
21. POULTON, J. 1998. Does a common mitochondrial DNA polymorphism underlie susceptibility to diabetes and the thrifty genotype? Trends Genet. 14: 387-389.
22. POULTON, J., M. SCOTT BROWN, A. COOPER, et al. 1998. A common mitochondrial DNA variant is associated with insulin resistance in adult life. Diabetologia 41: 54-58.
23. GERTLER, M.M., H.E. LEETMA, R.J. KOUTROUBY & E.D. JOHNSON. 1975. The assessment of insulin, glucose and lipids in ischemic thrombotic cerebrovascular disease. Stroke 6: 77-84.
24. PYORALA, M., H. MIETTINEN, M. LAAKSO & K. PYORALA. 1998. Hyperinsulinemia and risk of stroke in healthy middle-aged men. The 22 year follow-up results of the Helsinki Policeman Study. Stroke 29: 1860-1866.
25. FOLSOM, A.R., M.L. RASMUSSEN, L.E. CHAMBLESS, et al. 1999. Prospective associations of fasting insulin, body fat distribution, and diabetes with risk of ischemic stroke. Diabetes Care 22: 1077-1083.
26. WANNAMETHEE, S.G., I.J. PERRY & A.G. SHAPER. 1999. Nonfasting serum glucose and insulin concentrations and the risk of stroke. Stroke 30: 1780-1786.
27. LINDAHL, B., B. DINESEN, M. ELIASSON, et al. 2000. High proinsulin levels precede first-ever stroke in a nondiabetic population. Stroke 31: 2936-2941.
28. LAKKA, H.M., T.A. LAKKA, J. TUOMILEHTO, et al. 2000. Hyperinsulinemia and the risk of cardiovascular death and acute coronary and cerebrovascular events in men. Arch. Intern. Med. 160: 1160-1168.
29. SHINOZAKI, K., H. NARITOMI, T. SHIMIZU, et al. 1996. Role of insulin resistance associated with compensatory hyperinsulinemia in ischemic stroke. Stroke 27: 37-43.
30. BENDALL, K.E. & B.C. SYKES. 1995. Length heteroplasmy in the first hypervariable segment of the human mtDNA control region. Am. J. Hum. Genet. 57: 248-256.
31. MARCHINGTON, D.R., J. POULTON, A. SELLAR & I.J. HOLT. 1996. Do sequence variants in the major non-coding region of the mitochondrial genome influence mitochondrial mutations associated with disease. Hum. Mol. Genet. 5: 473-479.
32. POULTON, J., J. LUAN, V. MACAULAY, et al. 2002. Type 2 diabetes is associated with a common mitochondrial variant: evidence from a population-based case-control study. Hum. Mol. Genet. 11: 1581-1583.