Process modeling and simulation can guide process development: Case study α-cyclodextrin

Enzyme and Microbial Technology

Volumn 34, Issue 7, 2004, Pages 642-650

  Biwer, Arno ^a   Heinzle, Elmar ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

CGTase; Cyclodextrins; Downstream processing; Modeling; Process development; Simulation

Indexed keywords

COMPUTER SIMULATION; CONCENTRATION (PROCESS); ENZYMES; HUMAN REACTION TIME; PARAMETER ESTIMATION; PRODUCTION; SENSITIVITY ANALYSIS;

DOWNSTREAM PROCESSING; ENERGY SAVINGS; THERMOSTABLE ENZYMES; VARIATIONS PROCESS;

BIOTECHNOLOGY;

ALPHA CYCLODEXTRIN; CYCLOMALTODEXTRIN GLUCANOTRANSFERASE;

ANALYTICAL PARAMETERS; ARTICLE; BIOTECHNOLOGY; ENERGY CONSERVATION; ENZYME STABILITY; ENZYME SUBSTRATE; METHODOLOGY; PROCESS DEVELOPMENT; PROCESS MODEL; QUANTITATIVE ANALYSIS; REACTION TIME; SENSITIVITY ANALYSIS; SIMULATION; THERMOSTABILITY;

EID: 2342527026     PISSN: 01410229     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.enzmictec.2004.02.006     Document Type: Article

References (18)

1. McCoy M. Cyclodextrins: great product seeks a market. Chem. Eng. News. 77(9):1999;25-27
2. Biwer A., Antranikian G., Heinzle E. Enzymatic production of cyclodextrins. Appl. Microbiol. Biotechnol. 59:2002;609-617
3. Atwoods J, Davies JED, MacNicol DD, Vögtle F, Lehn J-M. In: Comprehensive supramolecular chemistry, vol. 3: Cyclodextrins. Oxford: Pergamon, 1996.
4. Schmid G. Preparation and industrial production of cyclodextrins. In: Comprehensive supramolecular chemistry, vol. 3: Cyclodextrins. Oxford: Pergamon; 1996. p. 41-56.
5. Bender H. Production, characterization, and application of cyclodextrins. Adv. Biotech. Process. 6:1986;31-71
6. Hedges A. Cyclodextrin: production, properties, and applications. In: Starch hydrolysis products. New York: VCH Publisher; 1992. p. 319-33.
7. Ammeraal R. Process for producing and separation cyclodextrins. US-Patent 4, 738, 923 (1988).
8. Atkins P. Physikalische Chemie. Weinheim: VCH; 1988.
9. Jordan E. Vapor pressure of organic compounds. New York: Interscience Publishers; 1954.
10. Blackwood A., Bucke C. Addition of polar organic solvents can improve the product selectivity of cyclodextrin glycosyltranferase. Enzyme Microb. Technol. 27:2000;704-708
11. Starnes R. Thermostable cyclodextrin glycosyl tranferase and processes using it. US-Patent 6, 184, 001 (2001).
12. Prowe S. Characterization of extracellular amylolytic enzymes and sodium coupled energy transduction of a newly isolated thermoalkaliplilic bacterium, Thermoalcalobacter bogoriae. PhD thesis, Technical University Hamburg-Harburg, 1996.
13. Pedersen S., Dijkhuizen L., Dijkstra B., et al. A better enzyme for cyclodextrins. Chemtech. 25:1995;19-25
14. Yang C, Su C. Methods of recovering and separating water-soluble cyclodextrins from cyclodextrin formation liquid. US-Patent 4, 970, 164 (1990).
15. Tsuchiyama Y., Nomura H., Okabe M., et al. A novel process of cyclodextrin production by the use of specific adsorbents. Part II. A new reactor system for selective production of α-cyclodextrin with specific adsorbents. J. Ferment. Bioeng. 71:1991;413-417
16. Okabe M., Tsuchiyama Y., Okamoto R. Development of a cyclodextrin production process using specific adsorbents. Bioprocess. Technol. 16:1993;109-130
17. Mäkelä M., Mattsson P., Korpela T. Specific adsorbents in isolation and purification of cyclodextrins. Biotechnol. Appl. Biochem. 11:1989;193-200
18. Yamamoto M., Horikoshi K. Isolation and purification of α-cyclodextrin by synthetic adsorption polymer. Starch/Stärke. 33:1981;244-246