A spatio-temporal simulation model of the response of solid tumours to radiotherapy in vivo: Parametric validation concerning oxygen enhancement ratio and cell cycle duration

Physics in Medicine and Biology

Volumn 49, Issue 8, 2004, Pages 1485-1504

  Antipas, Vassilis P ^a   Stamatakos, Georgios S ^a   Uzunoglu, Nikolaos K ^a   Dionysiou, Dimitra D ^a   Dale, Roger G ^b  

^a NATIONAL TECHNICAL UNIVERSITY OF ATHENS   (Greece)

^b CHARING CROSS HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; COMPUTER SIMULATION; CONFORMATIONS; FRACTIONATION; MATHEMATICAL MODELS; SHRINKAGE; TUMORS;

BIO-SIMULATION; INITIAL CELL PHASE DISTRIBUTION; NEOVASCULARIZATION;

RADIOTHERAPY;

OXYGEN; PROTEIN P53;

ALGORITHM; ANGIOGENESIS; ARTICLE; CANCER RADIOTHERAPY; CELL CYCLE; CONTROLLED STUDY; EXPERIENCE; EXPERIMENTAL MODEL; GENE MUTATION; GLIOBLASTOMA; GROWTH INHIBITION; HUMAN; HYPOTHESIS; IMAGE ANALYSIS; IN VIVO STUDY; MEDICAL LITERATURE; OXYGEN ENHANCEMENT RATIO; PARAMETRIC TEST; PREDICTION; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RADIATION DOSE FRACTIONATION; RADIOSENSITIVITY; SIMULATION; TREATMENT OUTCOME; TREATMENT PLANNING; TUMOR GROWTH; TUMOR VOLUME; WILD TYPE;

ALGORITHMS; BRAIN NEOPLASMS; CELL CYCLE; CELL DIVISION; COMPUTER SIMULATION; DOSE FRACTIONATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; GENES, P53; GLIOBLASTOMA; HUMANS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; OXYGEN; RADIATION TOLERANCE; RADIOBIOLOGY; RADIOTHERAPY DOSAGE; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; RADIOTHERAPY, CONFORMAL; TIME FACTORS;

EID: 2342512813     PISSN: 00319155     EISSN: None     Source Type: Journal    
DOI: 10.1088/0031-9155/49/8/008     Document Type: Article

References (53)

1. Baish J W and Jain R F 2000 Fractals and cancer Cancer Res. 60 3683-8
2. Beppu T, Kamada K, Yoshida Y, Arai H, Ogasawara K and Ogawa A 2002 Change of oxygen pressure in glioblastoma tissue under various conditions J. Neurooncol. 58 47-52
3. Brown J M and Wouters B G 1999 Apoptosis, p53, and tumor cell sensitivity to anticancer agents Cancer Res. 59 1391-9
4. Carmeliet P and Jain R K 2002 Angiogenesis in cancer and other diseases Nature 407 249-59
5. Chapman J D 2003 Single-hit mechanism of tumour cell killing by radiation Int. J. Radiat. Biol. 79 71-81
6. Chapman J D, Gillespie C J, Reuvers A P and Dugle D L 1975 The inactivation of Chinese hamster cells by x-rays: the effects of chemical modifiers on single- and double-events Radiat. Res. 64 365-75
7. Crafts D C, Hoshino T and Wilson C B 1977 Current status of population kinetics in gliomas Bull. Cancer 64 115-24
8. Curran R C and Crocker J 2000 Curran's Atlas of Histopathology 4th edn (Turnbout/Oxford: Harvey Miller Publishers Oxford University Press)
9. Duechting W 1990 Tumor growth simulation Comput. Graph. 14 505-8
10. Duechting W, Ulmer W, Lehrig R, Ginsberg T and Dedeleit E 1992 Computer simulation and modeling of tumor spheroid growth and their relevance for optimization of fractionated radiotherapy Strahlenther. Onkol. 168 354-60
11. Duechting W, Ginsberg T and Ulmer W 1995 Modeling of radiogenic responses induced by fractionated irradiation in malignant and normal tissue Stem Cells 13 301-6
12. Epstein R J 2003 Human Molecular Biology (Cambridge: Cambridge University Press) p 377
13. Groshar D, McEwan A J, Parliament M B, Rtasun R C, Golberg L E, Hoskinson M, Mercer J R, Mannan R H, Wiebe L I and Chapman J D 1993 Imaging tumor hypoxia and tumor perfusion J. Nucl. Med. 34 885-8
14. Haas-Kogan D A, Kogan S S, Levi D, Dazin P, T'Ang A, Fung Y and Israel M A 1995 Inhibition of apoptosis by the retinoblastoma gene product EMBO J. 14 461-72
15. 1 arrest and p53 independent apoptosis influence the radiobiologic response of glioblastoma Int. J. Radiat. Oncol. Biol. Phys. 36 95-103
16. Haas-Kogan D A, Kogan S S, Yount G L, Hsu J, Haas M, Deen D F and Israel M A 1999 p53 function influences the effect of fractionated radiotherapy on glioblastoma tumors Int. J. Radiat. Oncol. Biol. Phys. 43 399-403
17. Hashizume H, Baluk P, Morikawa S, McLean J W, Thurston G, Roberge S, Jain R K and McDonald D M 2000 Openings between defective endothelial cells explain tumor vessel leakiness Am. J. Pathol. 156 1363-80
18. 2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation Nat. Med. 3 177-82
19. Hobbs S K, Monsky W L, Yuan F, Roberts W G, Griffith L, Torchilin V P and Jain R K 1998 Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment Proc. Natl. Acad. Sci. USA 95 4607-12
20. Hoshino T 1992 Cell kinetics of glial tumors Rev. Neurol. 148 396-401
21. Jones B and Bleasdale C 1997 Influence of tumor regression and clonogen repopulation on tumor control by brachytherapy Modelling in Clinical Radiobiology (Freiburg Oncology Series monograph no 2) ed K Baier and D Baltas (Freiburg: Albert-Ludwigs-University) p 116-26
22. Kansal A R, Torquato S, Harsh G R, Chiocca E A and Deisboeck T S 2000a Simulated brain tumor growth dynamics using a three-dimensional cellular automaton J. Theor. Biol. 203 367-82
23. Kansal A R, Torquato S, Harsh I V, Chiocca E A and Deisboeck T S 2000b Cellular automaton of idealized brain tumor growth dynamics BioSystems 55 119-27
24. Katzung B G 2001 Basic and Clinical Pharmacology 8th edn (New York: Lange Medical Books/McGraw-Hill) p 926
25. Knisely J P and Rockwell S 2002 Importance of hypoxia in the biology and treatment of brain tumors Neuroimaging Clin. N. Am. 12 525-36
26. Kocher M and Treuer H 1995 Reoxygenation of hypoxic cells by tumor shrinkage during irradiation. A computer simulation Strahlenther. Onkol. 171 219-30
27. Kocher M, Treuer H, Voges J, Hoevels M, Sturm V and Muller R P 2000 Computer simulation of cytoxic and vascular effects of radiosurgery in solid and necrotic brain metastasis Radiother. Oncol. 54 149-56
28. Leenders K L 1994 PET: blood flow and oxygen consumption in brain tumors J. Neurooncol. 22 269-73
29. Lodish H, Baltimore D, Berk A, Zipursky S, Matsudaira P and Darnell J 1995 Molecular Cell Biology (New York: Scientific American Books)
30. MacIlwrath A J, Vassey P A, Ross G M and Brown R 1994 Cell cycle arrests and radiosensitivity of human tumour cell lines: dependence on wild-type p53 for radiosensitivity Cancer Res. 54 3178-722
31. Michelson S and Leith J T 1997 Positive feedback and angiogenesis in tumor growth control Bull. Math. Biol. 59 233-54
32. Nahum A and Sanchez-Nieto B 2001 Tumor control probability modelling: basic principles and applications in treatment planning Phys. Med. 17 (Suppl 2) 13-23
33. Nygren J and Ahnstrom G 1997 The oxygen effect in permeabilized and histone-depleted cells: an enhanced OER for DNA double-strand breaks compared to single-strand breaks is abolished by soluble scavengers Int. J. Radiat. Biol. 72 163-70
34. Palcic B, Korbelik M, Trotter M and Revesz L 1989 Oxygen enhancement ratio of fractionated regimens in vitro Radiat. Res. 117 409-18
35. Palcic B and Skarsgard L D 1984 Reduced oxygen enhancement ratio at low doses of ionizing radiation Radiat. Res. 100 328-39
36. Perez C and Brady L (ed) 1998 Principles and Practice of Radiation Oncology (Philadelphia, PA: Lippincott-Raven)
37. Perry M C (ed) 2001 The Chemotherapy Source Book (Philadelphia, PA: Lippincott Williams and Wilkins)
38. Potapov A A, Rapman Iu I, Liass F M, Manevich A Z and Iarmonenko S P 1983 Oxygenation of glioblastomas and normal brain tissue during radiation therapy Med. Radiol. (Mosk) 28 21-4
39. Revesz L and Palcic B 1985 Radiation dose dependence of the sensitization by oxygen and oxygen mimic sensitizers Acta Radiol. Oncol. 24 209-17
40. Smith J S et al 2001 PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme J. Natl Cancer Inst. 93 1246-56
41. Speke A and Hill R 1995 The effects of clamping and reoxygenation of repopulation during fractionated irradiation Int. J. Radiat. Biol. 31 857-63
42. Stamatakos G, Dionysiou D, Nikita K, Zamboglou N, Baltas D, Pissakas G and Uzunoglu N K 2001a In vivo tumor growth and response to radiation therapy: a novel algorithmic description Int. J. Radiat. Oncol. Biol. Phys. 51 (Suppl. 1) 240
43. Stamatakos G, Zacharaki E, Makropoulou M, Mouravliansky N, Marsh A, Nikita K and Uzunoglu N 2001b Modeling tumor growth and irradiation response in vitro - a combination of high-performance computing and web-based technologies including VRML visualization' IEEE Trans. Inform. Technol. Biomed. 5 279-89
44. Stamatakos G S, Dionysiou D D, Zacharaki E I, Mouravliansky N A, Nikita K S and Uzunoglu N K 2002 In silico radiation oncology: combining novel simulation algorithms with current visualization techniques Proc. IEEE 90 1764-77
45. Steel G (ed) 2002 Basic Clinical Radiobiology 3rd edn (London: Arnold)
46. Stuschke M, Budach V, Budach W, Feldmann H J and Sack H 1992 Radioresponsiveness sublethal damage repair and stem cell rate in spheroids from three human tumor lines: comparison with xenograft data Int. J. Radiat. Oncol. Biol. Phys. 24 119-26
47. Taghian A, du Bois W, Budach W, Baumann M, Freeman J and Suit H 1995 In vivo radiation sensitivity of glioblastoma multiforme Int. J. Radiat. Oncol. Biol. Phys. 32 99-104
48. Valk P E, Mathis C A, Prados M D, Gilbert J C and Budinger T F 1992 Hypoxia in human gliomas: demonstration by PET with fluorine-18-fluoromisonidazole J. Nucl. Med. 33 2133-7
49. Watson J, Hopkins N, Roberts J, Steitz J and Weiner A 1987 Molecular Biology of the Gene 4th edn (Menlo Park, CA: The Benjamin/Cummings Publishing)
50. Williams T and Bjerknes R 1972 Stochastic model for abnormal clone spread through epithelial basal layer Nature 236 19-21
51. Wu J K, Ye Z and Darras B T 1993 Frequency of p53 tumor suppressor gene mutations in human primary brain tumors Neurosurgery 33 824-30
52. Yetkin F Z and Mendelsohn D 2002 Hypoxia imaging in brain tumors Neuroimaging Clin. N. Am. 12 537-52
53. Yount G L, Haas-Kogan D A, Vidair C, Levi D, Haas M, Dewey W C and Israel M A 1996 Cell cycle synchrony unmasks influence of p53 function on radiation sensitivity of human glioblastoma cells Cancer Res. 56 500-6