Plasma PGE-2 levels and altered cytokine profiles in adherent peripheral blood mononuclear cells in non-small cell lung cancer (NSCLC)

Molecular Cancer

Volumn 1, Issue , 2002, Pages

  Hidalgo, Giovanna E ^a   Zhong, Li ^a   Doherty, Dennis E ^a   Hirschowitz, Edward A ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

IL10; Non small cell lung cancer; PGE 2

Indexed keywords

INTERLEUKIN 10; PROSTAGLANDIN E2; TUMOR MARKER; CYTOKINE;

ARTICLE; BLOOD ANALYSIS; CANCER CELL CULTURE; CELL ADHESION; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DISEASE MARKER; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IN VITRO STUDY; LUNG NON SMALL CELL CANCER; MONOCYTE; PROSTAGLANDIN BLOOD LEVEL; PROSTAGLANDIN SYNTHESIS; BLOOD; CELL LINE; COMPARATIVE STUDY; CYTOLOGY; KIDNEY; LUNG TUMOR; MONONUCLEAR CELL; PATHOLOGY; PHYSIOLOGY; PRENATAL DEVELOPMENT; TUMOR CELL LINE;

CARCINOMA, NON-SMALL-CELL LUNG; CELL ADHESION; CELL LINE; CELL LINE, TUMOR; CYTOKINES; DINOPROSTONE; HUMANS; INTERLEUKIN-10; KIDNEY; LEUKOCYTES, MONONUCLEAR; LUNG NEOPLASMS;

EID: 2342511159     PISSN: 14764598     EISSN: None     Source Type: Journal    
DOI: 10.1186/1476-4598-1-5     Document Type: Article

References (29)

1. Sulitzeanu D: Immunosuppressive factors in human cancer. Adv Cancer Res 1993, 60:247-67
2. Stolina M, Sharma S, Lin Y, Dohadwala M, Gardner B, Luo J, Zhu L, Kronenberg M, Miller PW, Portanova J, Lee JC, Dubinett SM: Specific inhibition of cyclooxygenase 2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesis. J Immunol 2000, 164:361-70
3. Huang M, Wang J, Lee P, Sharma S, Mao JT, Meissner H, Uyemura K, Modlin R, Wollman J, Dubinett SM: Human non-small cell lung cancer cells express a type 2 cytokine pattern. Cancer Res 1995, 55:3847-53
4. Huang M, Sharma S, Mao JT, Dubinett SM: Non-small cell lung cancer-derived soluble mediators and prostaglandin E2 enhance peripheral blood lymphocyte IL-10 transcription and protein production. J Immunol 1996, 157:5512-20
5. Huang M, Stolina M, Sharma S, Mao JT, Zhu L, Miller PW, Wollman J, Herschman H, Dubinett SM: Non-small cell lung cancer cyclooxygenase-2-dependent regulation of cytokine balance in lymphocytes and macrophages: up-regulation of interleukin 10 and down-regulation of interleukin 12 production. Cancer Res 1998, 58:1208-16
6. Snijdewint FG, Kalinski P, Wierenga EA, Bos JD, Kapsenberg ML: Prostaglandin E2 differentially modulates cytokine secretion profiles of human T helper lymphocytes. J Immunol 1993, 150:5321-9
7. van der Pouw Kraan TC, Boeije LC, Smeenk RJ, Wijdenes J, Aarden LA: Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production. J Exp Med 1995, 181:775-9
8. Wojciechowska-Lacka A, Matecka-Nowak M, Adamiak E, Lacki JK, Cerkaska-Gluszak B: Serum levels of interleukin-10 and interleukin-6 in patients with lung cancer. Neoplasma 1996, 43:155-8
9. Yanagawa H, Takeuchi E, Suzuki Y, Ohmoto Y, Bando H, Sone S: Presence and potent immuno-suppressive role of interleukin-10 in malignant pleural effusion due to lung cancer. Cancer Lett 1999, 136:27-32
10. De Vita F, Orditura M, Galizia G, Romano C, Roscigno A, Lieto E, Catalano G: Serum interleukin-10 levels as a prognostic factor in advanced non-small cell lung cancer patients. Chest 2000, 117:365-73
11. de Waal Malefyt R, Yssel H, Roncarolo MG, Spits H, de Vries JE: Interleukin-10. Curr Opin Immunol 1992, 4:314-20
12. Moore KW, O'Garra A, de Waal Malefyt R, Vieira P, Mosmann TR: Interleukin-10. Annu Rev Immunol 1993, 11:165-90
13. Beissert S, Hosoi J, Grabbe S, Asahina A, Granstein RD: IL-10 inhibits tumor antigen presentation by epidermal antigen-presenting cells. J Immunol 1995, 154:1280
14. Fiorentino DF, Zlotnik A, Vieira P, Mosmann TR, Howard M, Moore KW, O'Garra A: IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J Immunol 1991, 146:3444-51
15. Fiorentino DF, Zlotnik A, Mosmann TR, Howard M, O'Garra A: IL-10 inhibits cytokine production by activated macrophages. J Immunol 1991, 147:3815-22
16. Bogdan C, Vodovotz Y, Nathan C: Macrophage deactivation by interleukin 10. J Exp Med 1991, 174:1549-55
17. Nabioullin R, Sone S, Mizuno K, Yano S, Nishioka Y, Haku T, Ogura T: Interleukin-10 is a potent inhibitor of tumor cytotoxicity by human monocytes and alveolar macrophages. J Leukoc Biol 1994, 55:437-42
18. D'Andrea A, Aste-Amezaga M, Valiante NM, Ma X, Kubin M, Trinchieri G: Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med 1993, 178:1041-8
19. Sharma S, Stolina M, Lin Y, Gardner B, Miller PW, Kronenberg M, Dubinett SM: T cell-derived IL-10 promotes lung cancer growth by suppressing both T cell and APC function. J Immunol 1999, 163:5020-8
20. Williams CS, Mann M, DuBois RN: The role of cyclooxygenases in inflammation, cancer, and development. Oncogene 1999, 18:7908-16
21. Fosslien E: Molecular pathology of cyclooxygenase-2 in neoplasia. Ann Clin Lab Sci 2000, 30:3-21
22. Hida T, Yatabe Y, Achiwa H, Muramatsu H, Kozaki K, Nakamura S, Ogawa M, Mitsudomi T, Sugiura T, Takahashi T: Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas. Cancer Res 1998, 58:3761-4
23. Watkins DN, Lenzo JC, Segal A, Garlepp MJ, Thompson PJ: Expression and localization of cyclo-oxygenase isoforms in nonsmall cell lung cancer. Eur Respir J 1999, 14:412-8
24. Ochiai M, Oguri T, Isobe T, Ishioka S, Yamakido M: Cyclooxygenase-2 (COX-2) mRNA expression levels in normal lung tissues and non-small cell lung cancers. Jpn J Cancer Res 1999, 90:1338-43
25. Achiwa H, Yatabe Y, Hida T, Kuroishi T, Kozaki K, Nakamura S, Ogawa M, Sugiura T, Mitsudomi T, Takahashi T: Prognostic significance of elevated cyclooxygenase 2 expression in primary, resected lung adenocarcinomas. Clin Cancer Res 1999, 5:1001-5
26. Hosomi Y, Yokose T, Hirose Y, Nakajima R, Nagai K, Nishiwaki Y, Ochiai A: Increased cyclooxygenase 2 (COX-2) expression occurs frequently in precursor lesions of human adenocarcinoma of the lung. Lung Cancer 2000, 30:73-81
27. Gately MK, Wolitzky AG, Quinn PM, Chizzonite R: Regulation of human cytolytic lymphocyte responses by interleukin-12. Cell Immunol 1992, 143:127-42
28. Trinchieri G, Scott P: Interleukin-12: a proinflammatory cytokine with immunoregulatory functions. Res Immunol 1995, 146:423-31
29. Merendino RA, Gangemi S, Misefari A, Arena A, Capozza AB, Chillemi S, D'Ambrosio FP: Interleukin-12 and interleukin-10 production by mononuclear phagocytic cells from breast cancer patients. Immunol Lett 1999, 68:355-8