Are we overtreating rectal cancer: Time for another trial?

Annals of Surgical Oncology

Volumn 11, Issue 2, 2004, Pages 124-126

  Carne, Peter W G ^a   Nelson, Heidi ^a,b  

^a Division of Colon and Rectal Surgery   (United States)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER ADJUVANT THERAPY; CANCER CHEMOTHERAPY; CANCER PREVENTION; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER RISK; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CLINICAL PRACTICE; EDITORIAL; HUMAN; RECTUM CANCER; RECTUM SURGERY; SURVIVAL RATE; ADJUVANT THERAPY; METHODOLOGY; PATHOLOGY; RECTUM TUMOR; TREATMENT OUTCOME;

HUMANS; NEOADJUVANT THERAPY; RECTAL NEOPLASMS; TREATMENT OUTCOME;

EID: 2342504559     PISSN: 10689265     EISSN: None     Source Type: Journal    
DOI: 10.1245/ASO.2004.11.905     Document Type: Editorial

References (14)

1. Krook JE, Moertel CG, Gunderson LL, et al. Effective surgical adjuvant therapy for high-risk rectal carcinoma. N Engl J Med 1991;324:709-15.
2. Gastrointestinal Tumor Study Group. Prolongation of disease-free interval in surgically treated rectal carcinoma. N Engl J Med 1985;312:1465-72.
3. NIH Consensus Conference. Adjuvant therapy for patients with colon and rectal cancer. JAMA 1990;264:1444-50.
4. Kapiteijn E, Marijnen CAM, Nagtegaal ID, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 2001;345:638-46.
5. Heald RJ, Moran BJ, Ryall RD, Sexton R, MacFarlane JK. Rectal cancer: the Basingstoke experience of total mesorectal excision, 1978-1997. Arch Surg 1998;133:894-9.
6. Bokey EL, Öjerskog B, Chapuis PH, Dent OF, Newland RC, Sinclair G. Local recurrence after curative excision of the rectum for cancer without adjuvant therapy: role of total anatomical dissection. Br J Surg 1999;86:1164-70.
7. Vernava AM III, Moran M, Rothenberger DA, Wong WD. A prospective evaluation of distal margins in carcinoma of the rectum. Surg Gynecol Obstet 1992;175:333-6.
8. Adam IJ, Mohamdee MO, Martin IG, et al. Role of circumferential margin involvement in the local recurrence of rectal cancer. Lancet 1994;344:707-11.
9. Quirke P, Dixon MF, Durdey P, Williams NS. Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Lancet 1986;II:996-9.
10. Tepper JE, O'Connell MJ, Niedzwiecki D, et al. Impact of number of nodes retrieved on outcome in patients with rectal cancer. J Clin Oncol 2001;19:157-63.
11. Stocchi L, Nelson H, Sargent DJ, et al. Impact of surgical and pathological variables in rectal cancer: a United States community and cooperative group report. J Clin Oncol 2001;19:3895-3902.
12. Gunderson LL, Sargent DJ, Tepper JE, et al. Impact of T and N substage on survival and disease relapse in adjuvant rectal cancer: a pooled analysis. Int J Radiat Oncol Biol Phys 2002;54:386-96.
13. Tepper JE, O'Connell M, Niedzwiecki D, et al. Adjuvant therapy in rectal cancer: analysis of stage, sex, and local control - final report of the Intergroup 0114. J Clin Oncol 2002;20:1744-50.
14. Gunderson LL, Sargent DJ, Tepper J, et al. Impact of TN stage and treatment on survival and relapse in adjuvant rectal cancer pooled analysis (abstract 1008). Paper presented at: American Society of Clinical Oncology Annual Meeting; May 31 to June 3, 2003; Chicago, IL.