Effect of paraquat intoxication and ambroxol treatment on hydrogen peroxide production and lipid peroxidation in selected organs of rat

Veterinarski Arhiv

Volumn 74, Issue 2, 2004, Pages 141-155

  Anguelov, Anguel ^a,c   Chichovska, Maria ^b  

^a Regional Veterinary Station   (Bulgaria)

^b MEDICAL UNIVERSITY OF PLOVDIV   (Bulgaria)

^c Regional Veterinary Station   (Bulgaria)

Author keywords

Ambroxol; Hydrogen peroxide; Lipid peroxidation; Paraquat

Indexed keywords

ALKADIENE; AMBROXOL; HYDROGEN PEROXIDE; LIPID; LIPID PEROXIDE; MALONALDEHYDE; PARAQUAT; SCHIFF BASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BIOSYNTHESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; HEART; KIDNEY; LD 50; LIPID PEROXIDATION; LIVER; LUNG; MALE; NONHUMAN; PARAQUAT POISONING; RAT; REDUCTION;

ANIMALIA; RATTUS NORVEGICUS;

EID: 2342494804     PISSN: 03725480     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. BAINY, A. C., M. A. S. SILVA, M. KOGAKE, L. A. VIDELA (1994): Influence of lindane and paraquat on oxidative stress-related parameters of erythrocytes in vitro. Hum. Exp. Toxicol. 13, 461-465.
2. BEEBEEJAUN, A. R., G. BEEVERS, W. N. ROGERS (1971): Paraquat poisoning. Prolonged excretion. Clin. Toxicol. 4, 397-407.
3. BERISHA, H. I., H. PAKBAR, A. ABSOOD, S. SAID (1994): Nitric oxide as a mediator of lung injury due to paraquat. Proc. Natl. Acad. Sci. USA 91, 7445-7449.
4. BIANCHI, M., G. FANTUZZI, R. BERTINI, L. PERINI (1993): mRNA in human mononuclear cells and pulmonary epithelial cells. Cytokine 5, 525-530.
5. BUEGE, J. A., S. D. AUST (1978): Microsomal lipid peroxidation. Methods Enzymol. 52, 302-310.
6. BURK, R. F., R. A. LAWRENCE, J. M. LANE (1980): Liver necrosis and lipid peroxidation in the rat as the result of paraquat and diquat administration. J. Clin. Invest. 65, 1024-1031.
7. BUS, J. S., J. E. GIBSON (1984): Paraquat: model for oxidant-initiated toxicity. Environ. Health Perspect. 55, 37-46.
8. BUS, J. S., S. D. AUST, J. E. GIBSON (1975): Lipid peroxidation: a possible mechanism for paraquat toxicity. Res. Commun. Chem. Pathol. Pharmacol. 11, 31-38.
9. BUS, J. S., S. Z. CAGEN, M. OLGAAD, J. E. GIBSON (1976): A mechanism for paraquat toxicity in mice and rats. Toxicol. Appl. Pharmacol. 35, 501-513.
10. CERUTTII, P., Y. KAPANCI (1979): Effect of metabolite VIII of bromhexine (Na 872) on type II epithel of the lung. An experimental and morphological study with reference to surfactant secretion. Respiration 37, 241-251.
11. DAVIES, D. S., G. M. HAWKSWOTH, P. N. BENNET (1977): Paraquat poisoning. Proc. Eur. Soc. Toxicol. 18, 21-26.
12. DEARDEN, L. C., R. D. FAISHTER, D. M. McREA, W. R. SMITH, F. L. GLASE (1978): Pulmonary ultrastucture of the late aspects of human paraquat poisoning. Am. J. Pathol. 93, 667-676.
13. DONNINI, M., M. LUIDETTI, L. DIOMEDE (1990): Ambroxol reduces paraquat toxicity in the rat. Prog. Respir. Res. 25, 329-332.
14. FAIRSHTER, R. D. (1981): Paraquat toxicity and lipid peroxidation. Arch. Intern. Med. 141, 1121-1123.
15. FRASCHINI, F., F. SCAGLIONE, G. SCARPAZZA, F. MARCHI (1988): Effect of mucolytic agent on the bioavailability of antibiotics in patients with chronic respiratory diseases. Curr. Ther. Res. 43, 734-742.
16. KADIISKA, M. B., P. M. HANNA, R. P. MASON (1993): In vivo ESR. spin trapping evidence for hydroxyl radical-mediated toxicity of paraquat and copper in rats. Toxicol. Appl. Pharmacol. 123, 187-192.
17. LABARCA, C., K. PAIGEN (1980): A simple, rapid and sensitive DNA assay procedure. Anal. Biochem. 102, 344-352.
18. MURRAY, R. E., J. E. GIBSON (1972): A comparative study of paraquat intoxication in rats, guinea pigs and monkeys. Exp. Mol. Pathol. 17, 317-325.
19. NOWAK, D., T. PIETRAS, A. ANTCZAK, M. KROL, G. PIASECKA (1993): Ambroxol in-hibits endotoxin -induced lipid peroxidation in mice. Pol. J. Pharmacol. 45, 317-322.
20. NOWAK, D., A. ANTCHAK, T. PIERAS, P. BIALASIEWICZ, M. KROL (1994): Protective effect of ambroxol against heat- and hydrogen peroxide-induced damage to lung lipids in mice. Eur. Respir. J. 7, 1629-1634.
21. NOWAK, D., G. PIASECKA, A. ANTCZAK, T. PIETRAS (1991): Effect of ascorbic acid on hydroxyl radical generation by chemical, enzymatic and cellular systems. Importance for antioxidant prevention of pulmonary emphysema. Biomed. Biochem. Acta 50, 265-272.
22. NOWAK, D., G. PIASECKA, T. PIETRAS, A. ANTCZAK (1991a): Effect of ascorbic acid on killing of lymphocytes and macrophages by hydrogen peroxide. Biomed. Bioche. Acta 50, 1079-1086.
23. OHAKAWA, H., O. OHISHI, K. YAGI (1976): Assay of lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95, 351-358.
24. OLIVIERI, D., G. ZAVATTINI, G. TOMASINI, S. DAMIOTTI (1987): Ambroxol for the prevention of chronic bronchitis exacerbations: long-term multicenter trial. Respiration 51 (suppl. 1) 42-51.
25. OMAYE, S. T., K. A. REDDY, C. E. CROSS (1978): Enhanced lung toxicity of paraquat in selenium-deficient rats. Toxicol. Appl. Pharmacol. 43, 237-247.
26. PETTEN, G. R., G. J. MEARS, P. J. TAYLOR (1978): The effects of Na 872 on pulmonary maturation in the fetal lamb and rabbit. Am. J. Obs. Gynecol. 130, 35-40.
27. PORTER, N., S. E. CALDWELLI, K. A. MILLS (1995): Mechanisms of free radical oxidation of unsaturated lipids. Lipids 30, 277-290.
28. REDDY, K. A., R. E. LITOV, T. OMAVE (1977): Effect of pretreatment with antiinflammatory agents on paraquat toxicity in the rat. Res. Commun. Chem. Pathol. Pharmacol. 17, 87-100.
29. ROZNIECKI, J., D. NOWAK (1987): Effect of ambroxol on the chloramines T-induced decrease of serum elastase inhibitory capacity in vitro. Lung Respir. 4, 14-15.
30. 2 production by macrophages and neutrophils with homovanilinic acid and horse-radish peroxidase. J. Immunol. Methods 63, 347-357.
31. SALZER, H., H. WEIDINGER, G. SIMBRUNER (1986): Ambroxol versus Betamethason zur Forderung der antepartalen Lungenreife-eine multizentrische Studie. Z. Geburtshilfe. Perinatol. 190, 49-59.
32. SALMONA, M., M. DONNINI, L. PERIN, L. DOMEDE, M. ROMANO (1992): A novel pharmacological approach for paraquat poisoning in rat and A 549 cell line using ambroxol, a lung surfactant synthesis inducer. Food Toxicol. 30, 789-794.
33. SHARP, C. W., A. OTTOLENGHI, A. S. POSNER (1972): Correlation of paraquat toxicity with tissue concentration and weight loss of the rat. Toxicol. Appl. Pharmacol. 22, 241-251.
34. SMITH, D. J., D. HEATH, M. RAY (1973): The pathogenesis and structure of paraquat induced pulmonary fibrosis in rat. J. Pathol. 114, 57-67.
35. SHU, H., R. E. TALCOTT, S. A. RICE, E. T. WEI (1979): Lipid peroxidation and paraquat toxicity. Biochem. Pharmacol. 28, 327-331.
36. TAKENAKA, T., F. GOTO (1994): Alteration of lipid peroxidation and the activity of peroxide metabolism enzymes in the liver, kidney and lung following the administration of paraquat in mice. Masui J. 43, 34-40.
37. TOMITA, M., T. OKUYAMA (1993): Effect of paraquat on the malonyldialdehyde level in rat liver microsomes (in vitro). Arch. Toxicol. 68, 187-192.
38. WINSEL, K., G. BECHER (1992): Effect of ambroxolon chemiluminescence of phagocytic cells and Na-arachidonate induced bronchoconstriction in guinea pigs. Eur. Respir. 5 (suppl. 15), 298.
39. YAGY, K. (1987): Lipid peroxides and human diseases. Chem. Phys. Lipids 45, 337-351.