Haber's rule: The search for quantitative relationships in toxicology

Human and Ecological Risk Assessment

Volumn 9, Issue 6, 2003, Pages 1547-1559

  Bunce, Nigel J ^a   Remillard, Rene B J ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

Concentration time response effects; Haber's rule; Inhalation toxicology

Indexed keywords

HABER;

EID: 2342487285     PISSN: 10807039     EISSN: None     Source Type: Journal    
DOI: 10.1080/10807030390251038     Document Type: Article

References (38)

1. Atherley G. 1985. A critical review of time-weighted average as an index of exposure and dose, and of its key elements. Am Soc Hyg Assoc J 46:481-7
2. Bliss CI. 1937. The calculation of the time-mortality curve. Ann Appl Biol 24:815-52
3. Bliss CI. 1940. The relation between exposure time, concentration and toxicity in experiments on insecticides. Ann Entomol Soc Am 33:721-66
4. Bliss CI and James AT. 1966. Fitting the rectangular hyperbola. Biometrics 22:573-602
5. Chen GS, Chen JJ, and Bunce NJ. 2002. Divergence in mechanism between Ah receptor agonists and antagonists in the Ah receptor signal transduction pathway. Organohalogen Comp 55:445-8
6. Doll R. 1963. Interpretations of epidemiological data. Cancer Res 10:1613-23
7. Druckrey H. 1967. Quantitative aspects in chemical carcinogenesis. In: Truhaut R (ed), Potential Carcinogenic Hazard from Drugs: Evaluation of Risk. UICC Monograph Series, Springer Berlin 7:60-78
8. FluryF. 1921. Ueber Kampfgasvergiftungen I: ueber Reizgase. Z Exp Medizin 13:1-15, through Witschi (1999)
9. Flury F and Wirth W. 1934. Zur Toxikologie der Losungsmittel (verschiedene Ester, Aceton, Methylalkohol). Arch Gewerbepath Gewerbehyg 5:2-90
10. 2. Environ Health Perspect 30:23-9
11. Gaylor DW. 2000. The use of Haber's law in standard setting and risk assessment. Toxicol 149:17-9
12. Haber F. 1924. Zur Geschichte des Gaskrieges. Funf Vortrage aus den Jahren 1920-1923, Springer, Berlin, 77-92
13. Hayes FD, Short RD, and Gibson JE. 1973. Differential toxicity of monochloroacetate, monofluoroacetate, and monoiodoacetate in rats. Toxicol Appl Pharmacol 26:93-102
14. Henschler D. 1984. Exposure limits: history, philosophy, future developments. Ann Occup Hyg 28:79-92
15. Highfill JW, Hatch GE, Slade R, et al. 1992. Concentration-time models for the effects of ozone on broncioalveolar lavage fluid protein from rats and guinea pigs. Inhalation Toxicol 4:1-16
16. Jarabek AM. 1995. Consideration of temporal toxicity challenges current default assumptions. Inhalation Toxicol 7:927-46
17. Littlefield NA, Farmer JH, and Gaylor DW. 1979. Effects of dose and time in a long-term, low-dose carcinogenic study. J Environ Pathol Toxicol 3:17-34
18. Miller FJ, Schlosser PM, and Janszen DB. 2000. Haber's rule: A special case in a family of curves relating concentration and duration of exposure to a fixed level of response for a given endpoint. Toxicol 149:21-34
19. Moolgavkar SH. 1993. Cell proliferation and carcinogenesis models: General principles with illustrations from the rodent liver system. Environ Health Perspect 101(Suppl 5):91-4
20. Moolgavkar SH. 2001. Biologically based cancer risk assessment models. In: Choi WN (ed), Genetic Toxicology and Cancer Risk Assessment, pp 355-71. Marcel Dekker, NY, NY, USA
21. Nordling CO. 1953. A new theory on the cancer-inducing mechanism. Brit J Cancer 7:68-72
22. Ostwald von W and Dernoschenk A. 1910. Ueber die Beziehungen zwischen Adsorption und Giftgkeit. Kolloid Zeitschr 6:297-307
23. Pompei F and Wilson R. 2001. Age distribution of cancer: The incidence turnover at old age. Human Ecol Risk Assess 7:1619-50
24. Rajini P, Gelzleichter TR, Last JA, et al. 1993. Alveolar and airway cell kinetics in the lungs of rats exposed to nitrogen dioxide, ozone, and a combination of the two gases. Toxicol Appl Pharmacol 121:186-92
25. Remillard RBJ and Bunce NJ. 2002. Use of Haber's rule to estimate the risk of diabetes from background exposures to dioxin-like compounds. Toxicol Lett 131:161-6
26. Rozman KK. 1992. Search for the mechanism of toxicity of dioxins. Exp Toxicol Pathol 44:473-80
27. Rozman KK. 1999. Delayed acute toxicity of 1,2,3,4,6,7,8- heptachlorodibenzo-p-dioxin (HpCDD), after oral administration, obeys Haber's rule of inhalation toxicology. Toxicol Sci 49:102-9
28. Rozman KK. 2000. The role of time in toxicology or Haber's c x t product. Toxicol 149:35-42
29. Rozman KK and Doull J. 2001. The role of time as a quantifiable variable of toxicity and the experimental conditions when Haber's c x t product can be observed: Implications for therapeutics. J Pharmacol Exp Therap 296:663-8
30. Rozman KK, Kerecsen L, Viluksela MK, et al. 1996. A toxicologist's view of cancer risk assessment. Drug Metab Rev 28:29-52
31. ten Berg WF, Zwart A, and Appelman LM. 1986. Concentration-time mortality response relationship of irritant and systemically acting vapours and gases. J Hazardous Mater 13:301-9
32. 50 vs. time model for the aquatic toxicity of reactive and receptor-mediated compounds. Consequences for bioconcentration kinetics and risk assessment. Environ Sci Technol 33:758-63
33. Viluksela M, Stahl BU, Birnbaum LS, et al. 1997. Subchronic/chronic toxicity of 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin (HpCDD) in rats I: design, general observations, hematology and liver concentrations. Toxico Appl Pharmacol 146:207-16
34. Viluksela M, Stahl BU, Birnbaum LS, et al. 1998. Subchronic/chronic toxicity of four chlorinated dibenzo-p-dioxins in rats. Toxicol Appl Pharmacol 151:57-69
35. Warren E. 1900. On the reaction of Daphnia magna (Straus) to certain changes in its environment. Quart J Microscopic Sci 43:199-224
36. Weller E, Long N, Smith A, et al. 1999. Dose-rate effects of ethylene oxide exposure on developmental toxicity. Toxcicol Sci 50:259-70
37. Witschi H. 1999. Some notes on the history of Haber's Law. Toxicol Sci 50:164-8
38. Zwart A and Woutersen RA. 1988. Acute inhalation toxicity of chlorine in rats and mice: Time concentration-mortality relationships and effects of respiration. J Hazardous Mater 19:195-208